Engineered immune cells injected directly into the brain take on childhood tumors
NCT ID NCT05768880
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests a new treatment called SC-CAR4BRAIN for children and young adults with certain aggressive brain tumors, including DIPG and DMG. The treatment involves taking a patient's own immune T cells, engineering them in a lab to recognize and attack tumor cells, and then delivering them directly into the fluid-filled spaces of the brain through a small tube. The study aims to see if this approach is safe and to find the best dose for future studies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SC-CAR4BRAIN (a type of CAR T cell therapy that targets four proteins on tumor cells)
- What this could lead to
- If it works, this could point toward a new treatment option for children and young adults with hard-to-treat brain tumors like DIPG and DMG.
- What could go wrong
- This is an early Phase 1 trial, so the main goals are safety and finding the right dose. It is too soon to know if it will be effective, and there may be side effects from the treatment or the catheter used to deliver it.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Seattle Children's Hospital
Seattle, Washington, 98105, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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