Quad-Target CAR t cells injected into brain show promise for childhood cancers
NCT ID NCT05768880
First seen Nov 20, 2025 · Last updated Apr 24, 2026 · Updated 22 times
Summary
This early-phase study tests a special immune cell therapy (Quad CAR T cells) given directly into the fluid around the brain for children and young adults with aggressive brain tumors like DIPG, DMG, or other recurrent CNS cancers. The therapy uses a patient's own T cells, engineered to attack four different targets on tumor cells. The main goals are to see if the treatment is safe and to find the best dose.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
Conditions
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