GERM CELL TUMOR

This study is testing whether taking two oral drugs, zanzalintinib and etoposide, as long-term 'maintenance' therapy can help keep cancer from returning in patients with relapsed germ cell tumors (like testicular cancer). The goal is to see if this combination is safe and can ext…

This study is testing whether combining two existing chemotherapy drugs, teniposide and cisplatin, can safely and effectively treat newly diagnosed central malignant germ cell tumors in the brain. It will involve about 40 patients who will receive the drug combination every three…

This is the first study in humans to test the safety and find the right dose of a new drug called XmAb541 for people with advanced solid tumors, including ovarian, endometrial, and germ cell cancers. The main goal is to see how well the drug is tolerated and to check for side eff…

This large study has two main goals. First, it tests if close monitoring after surgery is a safe approach for children and adults with low-risk germ cell tumors, avoiding chemotherapy unless the cancer returns. Second, for patients with higher-risk tumors that need treatment, it …

This early-stage study is testing a new cell therapy for children and young adults with aggressive or returning brain tumors. Doctors collect a patient's own immune cells, engineer them in a lab to target a protein (B7H3) found on tumor cells, and then deliver these 'CAR T cells'…

This study is testing a new, minimally invasive robot-assisted technique to find out if testicular cancer has spread to nearby lymph nodes. Currently, many patients receive strong chemotherapy or surgery they might not need. The new method uses a special green dye and a robot to …

This study is testing if a daily low-dose aspirin pill can prevent dangerous blood clots in men with advanced testicular or germ cell cancer who are receiving chemotherapy. The trial will enroll 35 participants at high risk for clots to take aspirin daily for 6 months while under…

This study follows over 1,100 children and young adults who survived germ cell tumors to understand the long-term effects of their cancer treatments. Researchers will collect health information and analyze tumor samples to identify genetic patterns that could predict which patien…

This study aims to build a DNA registry to better understand testicular and germ cell tumors. Researchers will collect genetic and health information from 1,000 people, including patients, their family members, and unrelated healthy individuals. By comparing these groups, they ho…

This study is collecting information on people with various types of brain tumors to see if a new, more detailed way of classifying them helps doctors choose better treatments and predict outcomes more accurately. It will follow about 1,650 patients for up to five years to compar…