New Antibody-Drug conjugate ZW251 enters first human trials for Hard-to-Treat cancers
NCT ID NCT07164313
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial is testing a new drug called ZW251 in about 100 people with advanced solid tumors, including liver cancer (hepatocellular carcinoma), a type of lung cancer (squamous cell non-small cell lung cancer), and germ cell tumors. ZW251 is an antibody-drug conjugate designed to deliver a cancer-killing agent directly to cells that have a protein called glypican-3 on their surface. The main goals are to check the drug's safety and find the right dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ZW251 (an antibody-drug conjugate that targets a protein called glypican-3 on cancer cells)
- What this could lead to
- If it works, this could point toward a new treatment option for people with advanced liver, lung, or germ cell cancers that have not responded to other therapies.
- What could go wrong
- This is a very early (Phase 1) trial with only 100 participants, so the drug may not be effective or may cause serious side effects. It is too soon to know if it will help patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Clinica Universidad de Navarra
RECRUITINGPamplona, 31008, Spain
Contact
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
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Hospital Universitario Vall d'Hebron
RECRUITINGBarcelona, 08035, Spain
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Hospital Universitario Virgen de la Victoria
RECRUITINGMálaga, 29010, Spain
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Kansai Medical University Hospital
RECRUITINGOsaka, 573-1191, Japan
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Kyoto University Hospital
RECRUITINGKyoto, 606-8507, Japan
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065-6800, United States
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NEXT Oncology Madrid
RECRUITINGMadrid, 28223, Spain
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National Cancer Center East
RECRUITINGKashiwa, 2778577, Japan
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National Cancer Center Hospital
RECRUITINGTokyo, 104-0045, Japan
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National Taiwan University Hospital
RECRUITINGTaipei, 100225, Taiwan
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Norton Cancer Institute
RECRUITINGLouisville, Kentucky, 40202, United States
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START - Dublin Mater Misericordiae University Hospital (MMUH)
RECRUITINGDublin, D07 R2WY, Ireland
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START - Rioja Hospital Universitario San Pedro
RECRUITINGLogroño, 26006, Spain
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START Barcelona
RECRUITINGBarcelona, 29010, Spain
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START Lisboa a - Unidade de Ensaios ClÃnicos - Hospital de Santa Maria
RECRUITINGLisbon, 1649-035, Portugal
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START Madrid Hospital Universitario Fundacion Jimenez Diaz
RECRUITINGMadrid, 28040, Spain
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START Madrid Hospital Universitario HM Sanchinarro - CIOCC
RECRUITINGMadrid, 28050, Spain
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START Midwest
RECRUITINGGrand Rapids, Michigan, 49546, United States
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START San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
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Taipei Veterans General Hospital
RECRUITINGTaipei, 112201, Taiwan
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UCSF Comprehensive Cancer Center
RECRUITINGSan Francisco, California, 94158, United States
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Unidade Local de Saúde Gaia e Espinho
RECRUITINGVila Nova de Gaia, 4434-502, Portugal
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University of California Los Angeles - Cancer Care - Santa Monica (UCLA)
RECRUITINGSanta Monica, California, 90404, United States
Contact
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a cancer vaccine prime the body to better fight liver tumors?
- Training the immune system to hunt down leftover liver cancer cells
- Can a new drug ST316 shrink Hard-to-Treat tumors?
- Could a genetic marker guide future cancer therapies in taiwan?
- Can a tumor-zapping procedure also wake up the immune system?
- A machine that keeps donor livers alive outside the body — could it transform transplantation?