Experimental drug cocktail aims to outsmart childhood cancers
NCT ID NCT04308330
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests a four-drug combination—vorinostat plus three chemotherapy drugs—in children, teens, and young adults up to age 30 whose solid tumors or brain cancers have returned or not responded to standard treatment. The main goal is to find the safest dose of vorinostat when used with the other drugs, and to see what side effects occur. Up to 30 participants will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- vorinostat (Zolinza) combined with vincristine, irinotecan, and temozolomide
- What this could lead to
- If it works, this could point toward a new treatment option for children and young adults with hard-to-treat cancers that have come back or not responded to standard therapy.
- What could go wrong
- This is a very early Phase 1 trial with only 30 participants, focused on finding a safe dose. The combination may not shrink tumors or could cause severe side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
New York Medical College
RECRUITINGValhalla, New York, 10595, United States
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