New brain tumor labels could guide better treatments
NCT ID NCT05259605
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is collecting data from 1,650 people with various brain tumors to see if the updated 2021 WHO classification system helps doctors group patients more accurately and choose better treatments. Researchers will track responses to therapy, survival, and tumor features over 5 years. The goal is to create provisional treatment guidelines for newly defined tumor types based on real-world experience.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors better classify brain tumors and choose more effective treatments based on the latest diagnostic criteria.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly test new therapies. Results may take years and might not change current practice immediately.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AZ Delta - Campus Rumbeke
RECRUITINGRoeselare, Belgium
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Azienda Ospedaliero-Universitaria Careggi
RECRUITINGFlorence, Italy
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C.H.U. Sart-Tilman
RECRUITINGLiège, Belgium
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CHU Lyon - Hopital neurologique Pierre Wertheimer
RECRUITINGLyon, France
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Centre Hospitalier Universitaire Vaudois
RECRUITINGLausanne, Switzerland
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Centro Hospitalar Universitario Lisboa Norte - Hospital Sta. Maria
RECRUITINGLisbon, Portugal
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Diagnostic & Therapeutic Center of Athens Hygeia Hospital S.A.
RECRUITINGAthens, Greece
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Erasmus MC
RECRUITINGRotterdam, Netherlands
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Hopital de La Timone
RECRUITINGMarseille, France
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Hopital la Pitie-Salpetriere
RECRUITINGParis, France
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Hospital Clinic de Barcelona
RECRUITINGBarcelona, Spain
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Hospital De La Santa Creu I Sant Pau
RECRUITINGBarcelona, Spain
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Hospital Duran i Reynals
RECRUITINGL'Hospitalet de Llobregat, Spain
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Hospital Germans Trias i Pujol (Institut Catala D'Oncologia)
RECRUITINGBarcelona, Spain
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IRCCS Ospedale San Raffaele
RECRUITINGMilan, 20132, Italy
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IRCCS-Regina Elena National Cancer Center
RECRUITINGRoma, 00144, Italy
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Innsbruck Universitaetsklinik
RECRUITINGInnsbruck, Austria
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Institut Catala d'Oncologia - ICO L'Hospitalet - Hospital Duran i Reynals
RECRUITINGL'Hospitalet de Llobregat, Barcelona, 08908, Spain
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Institut Jules Bordet
RECRUITINGAnderlecht, Belgium
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Instituto Portugues de Oncologia de Lisboa Francisco Gentil - EPE
RECRUITINGLisbon, Portugal
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Istituto Neurologico Carlo Besta
RECRUITINGMilan, Italy
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Istituto Oncologico Veneto
RECRUITINGPadova, Italy
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Knappschaft Krankenhaus Langendreer
RECRUITINGBochum, 44892, Germany
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Leiden University Medical Centre
RECRUITINGLeiden, Netherlands
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NHS Lothian - The Royal Infirmary Of Edinburgh
RECRUITINGEdinburgh, EH16 4SA, United Kingdom
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Newcastle Hospitals NHS Trust - Freeman Hospital, Northern Centre For Cancer Care
RECRUITINGNewcastle upon Tyne, United Kingdom
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Nottingham University Hospitals NHS Trust - City Hospital
RECRUITINGNottingham, United Kingdom
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Onze Lieve Vrouw Ziekenhuis
RECRUITINGAalst, Belgium
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Oslo University Hospital - Radiumhospitalet
RECRUITINGOslo, Norway
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Ospedale Bellaria-Bologna
RECRUITINGBologna, Italy
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Ospedale San Giovanni - Dipartimento Neuroscienze
RECRUITINGTorino, Italy
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The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis
RECRUITINGAmsterdam, Netherlands
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UniversitaetsSpital Zurich - Neurology Clinic
RECRUITINGZurich, Switzerland
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Universitaetsklinikum - Essen
RECRUITINGEssen, 45147, Germany
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Universitaetsklinikum Bonn
RECRUITINGBonn, 53105, Germany
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Universitaetsklinikum Jena
RECRUITINGJena, 07447, Germany
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Universitaetsklinikum Koeln
RECRUITINGCologne, 50937, Germany
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Universitaetsklinikum Leipzig-Klinik fuer Strahlentherapie und Radioonkologie
RECRUITINGLeipzig, Germany
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Universitaetsklinikum Regensburg
RECRUITINGRegensburg, Germany
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Universitaetsklinikum Wien - AKH unikliniken
RECRUITINGVienna, Austria
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Universitair Ziekenhuis Brussel
RECRUITINGBrussels, Belgium
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University Hospital Frankfurt -Senckenberg Institute of Neurooncology
RECRUITINGFrankfurt, Germany
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a Tumor's genetic blueprint guide better treatment for kids with brain cancer?
- Can engineered immune cells tackle an incurable childhood brain tumor?
- Can adding lenvatinib to standard care outsmart a tough brain cancer?
- Can a sharper beam of radiation shield the mind during brain tumor treatment?
- Could an antiparasitic drug boost radiation against childhood brain tumors?