GERM CELL TUMOR
Clinical trials for GERM CELL TUMOR explained in plain language.
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Could a dementia drug shield kids' brains from radiation damage?
Disease control CompletedThis pilot study tested whether memantine, a drug used for dementia in adults, could help prevent memory and thinking problems in children receiving brain radiation for tumors like glioma or craniopharyngioma. 41 children aged 6-21 took either memantine or a placebo during radiat…
Matched conditions: GERM CELL TUMOR
Phase: PHASE2 • Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Experimental CAR T-Cell therapy targets rare testicular cancer
Disease control CompletedThis phase 2 study tested a new treatment for nonseminomatous germ cell tumors (a type of testicular cancer) that had not responded to standard therapy. The treatment used the patient's own immune cells (T cells) that were genetically modified to recognize and attack cancer cells…
Matched conditions: GERM CELL TUMOR
Phase: PHASE2 • Sponsor: UNC Lineberger Comprehensive Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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New stem cell transplant shows promise for kids with tough cancers
Disease control CompletedThis study tested a new way to do stem cell transplants in 23 children with cancers that came back or didn't respond to treatment. The method removes certain immune cells from the donor's stem cells to help the child's body recover faster and fight infections better. The goal was…
Matched conditions: GERM CELL TUMOR
Phase: PHASE1 • Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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Immune cells injected directly into brain show promise for kids with tough tumors
Disease control CompletedThis early-stage study tested a new treatment for children and young adults with brain tumors that came back or didn't respond to standard therapy. Doctors took the patients' own immune cells, modified them to recognize a protein called EGFR on tumor cells, and injected them dire…
Matched conditions: GERM CELL TUMOR
Phase: PHASE1 • Sponsor: Seattle Children's Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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New hope for kids with rare cancer: sirolimus combo shows promise
Disease control CompletedThis study tested a new combination of drugs (sirolimus plus chemotherapy) in 32 children with recurrent or refractory yolk sac tumors, a rare type of germ cell tumor. The goal was to see if the combination could shrink tumors and improve survival. The treatment was given in cycl…
Matched conditions: GERM CELL TUMOR
Phase: PHASE2, PHASE3 • Sponsor: Shandong First Medical University • Aim: Disease control
Last updated Jun 26, 2026 19:11 UTC
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Old drug, new hope: thalidomide combo shows promise for kids with rare cancer
Disease control CompletedThis completed phase 2 trial tested a combination of thalidomide and three chemotherapy drugs (nab-paclitaxel, gemcitabine, epirubicin) in 20 children with relapsed or refractory yolk sac tumor, a rare germ cell cancer. The goal was to see if this new mix could shrink tumors or l…
Matched conditions: GERM CELL TUMOR
Phase: PHASE2 • Sponsor: Shandong First Medical University • Aim: Disease control
Last updated Jun 26, 2026 17:46 UTC
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Scientists hunt for testicular cancer genes in families
Knowledge-focused CompletedThis study aims to understand why testicular cancer sometimes runs in families. Researchers will collect DNA samples and medical information from about 750 people in families with multiple cases of testicular cancer. No treatment is given; the goal is to find genes that increase …
Matched conditions: GERM CELL TUMOR
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC