GERM CELL TUMOR

This early-stage study tests a new drug called XmAb541 in people with advanced ovarian, endometrial, or germ cell tumors that have not responded to prior treatments. The main goals are to check if the drug is safe and to find the best dose. About 282 participants will receive the…

This study tests whether combining two chemotherapy drugs, teniposide and cisplatin, can shrink or control newly diagnosed central malignant germ cell tumors in the brain. About 40 participants will receive the treatment, and researchers will monitor safety, effectiveness, and lo…

This early-phase study tests a four-drug combination (vorinostat, vincristine, irinotecan, and temozolomide) in children, teens, and young adults up to age 30 whose solid tumors or brain cancers have returned or not responded to standard treatment. The main goals are to find a sa…

This early-phase study tests a new drug called ZW251 in people with advanced liver cancer, a type of lung cancer, or certain germ cell tumors. The drug is designed to seek out and attack cancer cells while sparing healthy ones. The main goals are to check safety and find the righ…

This early-stage study is testing whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG or recurrent medulloblastoma. The cells are designed to recogn…

This study looks at two approaches for people with germ cell tumors. For low-risk patients, doctors will monitor closely after surgery to see if the tumor comes back. For standard-risk patients whose cancer has spread, the study compares two chemotherapy drugs (carboplatin vs cis…

This study tests whether taking two drugs (zanzalintinib and oral etoposide) after high-dose chemotherapy can help keep relapsed germ-cell tumors from growing back. About 38 adults whose cancer has not been cured by standard treatments will participate. The goal is to see if this…

This study is testing a new, more precise robot-assisted technique that uses a special dye (ICG) to find if testicular cancer has spread to nearby lymph nodes. Current methods often miss small cancer deposits, leading to either under- or overtreatment. The goal is to see if this …

This study tests whether a daily low-dose aspirin can prevent dangerous blood clots in people with advanced germ cell cancer (including testicular cancer) who are receiving standard chemotherapy. About 35 participants at high risk for clots will take aspirin alongside their chemo…

This study creates a registry of DNA and health information from 1,000 people with germ cell or testicular tumors, plus their relatives and unrelated volunteers. By comparing genetic data, researchers hope to learn why some people develop these tumors and others do not. Participa…

This study follows over 1,100 children and teens diagnosed with germ cell tumors to learn about short- and long-term side effects from treatment, like hearing loss. Researchers will also analyze tumor DNA and other markers to better predict which patients might have their cancer …

This study looks at whether a safe green dye, called ICG, can help surgeons see if cancer has spread to nearby lymph nodes in children with solid tumors. About 10 children under 18 who need lymph node surgery will get the dye injected during their operation. The goal is to see if…

This study looks at how the latest brain tumor classification system (from 2021) helps doctors better understand and treat different types of brain tumors. Researchers will collect data from 1,650 patients to see if the new system groups patients more accurately and to create tre…