Could a statin and arthritis drug tame childhood brain cancer?

NCT ID NCT02115074

Completed Disease control Sponsor: Centre Oscar Lambret Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tested a combination of two drugs—fluvastatin (a cholesterol-lowering statin) and celecoxib (an arthritis drug)—in 20 children and young adults with certain brain tumors (gliomas) that had come back or not responded to treatment. The goal was to find the safest dose of fluvastatin when given with a fixed dose of celecoxib, and to see if the combo could help control the disease. The study was completed, but results are not yet reported.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fluvastatin and Celecoxib (Celebrex)
What this could lead to: If this works, it could point toward a new way to control certain childhood brain tumors without harsh side effects.
What could go wrong: This is a very early, small phase 1 trial with only 20 participants. It is designed to find a safe dose, not to prove the treatment works. The drugs may not shrink tumors or improve survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioma malignant glioma optic pathway glioma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOMA

Contacts and locations

Locations

CHU Angers

Angers, 49933, France
Centre Hospitalier de Nancy

Vandœuvre-lès-Nancy, 54511, France
Centre Hospitalier de Purpan - Hôpital des Enfants

Toulouse, 31026, France
Centre Hospitalier de Strasbourg

Strasbourg, 67098, France
Centre Léon Bérard

Lyon, 69373, France
Centre Oscar Lambret

Lille, 59020, France
Hôpital pour enfants La Timone

Marseille, 13385, France
Institut Curie

Paris, 75005, France

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