Experimental combo targets Hard-to-Treat brain cancers

NCT ID NCT07243470

Recruiting now Disease control Sponsor: Centre Leon Berard Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests two drugs—tarlatamab and temozolomide—in adolescents and adults with high-grade brain tumors that have a specific marker called DLL3. The goal is to see if the combination is safe and can shrink tumors. About 70 participants will be enrolled across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tarlatamab and temozolomide
What this could lead to: If successful, this combination could offer a new treatment option for people with aggressive brain tumors that express DLL3.
What could go wrong: This is an early-phase trial with only 70 participants, so results may not apply to everyone. The combination may cause serious side effects, and it is not yet known if it will shrink tumors or improve survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

central nervous system cancer central nervous system neoplasm childhood neoplasm glioma malignant glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CNS TUMOR, ADULT CNS TUMOR, CHILDHOOD GLIOMA

Contacts and locations

Locations

CHU de Bordeaux
NOT_YET_RECRUITING

Bordeaux, 33000, France
Centre Léon Bérard
RECRUITING

Lyon, 69373, France
Centre Oscar Lambret
NOT_YET_RECRUITING

Lille, 59000, France
Hôpital Neurologique Pierre Wertheimer
RECRUITING

Bron, 69677, France
Hôpital Saint-André
NOT_YET_RECRUITING

Bordeaux, 33075, France
Hôpital Universitaire d'Angers
NOT_YET_RECRUITING

Angers, 49933, France
Hôpital de la Timone - service adulte
RECRUITING

Marseille, 13005, France
Hôpital de la Timone - service pédiatrie
RECRUITING

Marseille, France
Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix
NOT_YET_RECRUITING

Paris, 75013, France
IUCT - Claudius Regaud
RECRUITING

Toulouse, 31100, France
Institut Gustave Roussy
NOT_YET_RECRUITING

Villejuif, 94085, France
Institut de Cancérologie de l'Ouest
RECRUITING

Angers, 49055, France

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