Engineered immune cells take on deadly brain tumors
NCT ID NCT06355908
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests a personalized cell therapy called IL13Rα2 CAR-T for people with recurrent grade 4 glioma, an aggressive brain cancer. The treatment involves collecting a patient's immune cells, engineering them to target a protein on tumor cells, and infusing them back into the brain. The main goal is to check safety, but researchers will also look for signs of tumor shrinkage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- IL13Rα2-targeted CAR-T cells
- What this could lead to
- If successful, this could point toward a new treatment option for recurrent grade 4 glioma, a brain cancer with few effective therapies.
- What could go wrong
- This is a very early Phase 1 trial with only 30 participants, so it may not show clear benefit. The treatment is suspended, and there are risks like brain inflammation or other serious side effects from CAR-T therapy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beijing Tiantan Hospital
Beijing, China
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Other studies related to the condition(s) this trial covers.
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