Children's Oncology Group

This phase III trial tests whether tailoring treatment based on tumor features can improve outcomes for children with favorable histology Wilms tumor, the most common kidney cancer in kids. Over 1,600 participants will receive risk-adapted therapy, including chemotherapy and imag…

This phase 3 trial tests whether adding the targeted drug inotuzumab ozogamicin to standard chemotherapy and immunotherapy improves outcomes for children and young adults with high-risk B-cell acute lymphoblastic leukemia (B-ALL). The study will enroll about 6,000 participants an…

This large phase 3 trial is testing whether a new formulation of two chemotherapy drugs (CPX-351) and a targeted drug called gilteritinib can improve outcomes for children and young adults with newly diagnosed acute myeloid leukemia (AML). The study compares these new approaches …

This study tests a drug called inotuzumab ozogamicin in children and young adults (ages 1 to 21) whose B-cell acute lymphoblastic leukemia (B-ALL) has returned or not responded to standard treatment. The drug works like a guided missile, attaching to a marker (CD22) on cancer cel…

This study looks at whether a drug called dexrazoxane can help prevent heart damage in children and teens who have been treated for certain cancers like leukemia, lymphoma, and osteosarcoma. Researchers will measure heart function and blood markers in 420 survivors to see if dexr…

This study tests a new drug called AZD1390 given alongside radiation therapy for children with aggressive brain tumors (high-grade glioma, DIPG, or DMG). The drug blocks cancer cells from repairing damage caused by radiation, potentially making treatment more effective. About 54 …

This study tests two powerful chemotherapy combinations in children with a rare, aggressive kidney cancer called Wilms tumor. One group has newly diagnosed disease, the other has cancer that returned after initial treatment. The goal is to see if these drug mixes can stop the can…

This phase II trial is testing whether giving a lower dose of radiation after chemotherapy can effectively treat children and young adults with central nervous system germinomas, a type of brain tumor. The study will enroll 240 participants aged 3 to 29. After initial chemotherap…

This study tests whether the antiviral drug letermovir can prevent cytomegalovirus (CMV) infection in children and teens who have had a stem cell transplant. About 105 participants aged 2 to 17 will receive letermovir and be monitored for 14 weeks. The goal is to see if the drug …

This study tests whether sodium thiosulfate can reduce hearing loss caused by cisplatin chemotherapy in children with medulloblastoma, a type of brain cancer. It also explores whether low-risk patients can be treated with less intense radiation to reduce side effects. About 225 c…

This phase 3 trial studies two approaches for germ cell tumors. For low-risk patients whose tumor has been removed, doctors will monitor them closely instead of giving chemotherapy. For standard-risk patients whose cancer has spread, the trial compares two chemotherapy drugs—carb…

This phase 2 trial tests a personalized approach for children and young adults with a rare brain tumor called non-germinomatous germ cell tumor (NGGCT). Patients first receive chemotherapy, and then the type and amount of radiation they get depends on how well the tumor responds.…

This study tests a new drug called CBL0137 in children and young adults (ages 1 to 21) whose solid tumors, brain tumors, or lymphoma have returned or stopped responding to treatment. The goal is to find the best dose, check side effects, and see if the drug can shrink tumors. The…

This phase 3 trial studies the best way to treat pleuropulmonary blastoma (PPB), a rare childhood lung tumor. For type I PPB, it compares surgery alone to surgery plus chemotherapy. For types II and III, it tests adding the drug topotecan to standard chemotherapy. About 110 child…

This study compares two types of surgery to remove lung tumors that have spread from osteosarcoma (a bone cancer). One method uses a single large cut (open surgery), while the other uses several small cuts and a camera (keyhole surgery). The goal is to see which approach helps pa…

This phase 3 trial is for children and young adults with newly diagnosed, low-risk rhabdomyosarcoma, a soft tissue cancer. It tests whether a shorter course of two chemotherapy drugs (vincristine and dactinomycin) can maintain high cure rates while reducing treatment burden for v…

This study tests a new drug called DT2216 combined with the chemotherapy irinotecan in children, teens, and young adults whose solid tumors have come back or not responded to treatment. The goal is to find the safest dose and see if the combination can shrink tumors, especially i…

This phase 3 trial tests whether the drug triptorelin can protect the ovaries of adolescents and young adults with cancer who are receiving chemotherapy. Chemotherapy can damage the ovaries, making it hard or impossible to get pregnant later. Triptorelin temporarily pauses ovaria…

This study tests a drug called tegavivint in children, teens, and young adults whose solid tumors have come back or stopped responding to treatment. The goal is to find the safest dose and see if it can shrink tumors by blocking a key growth signal inside cancer cells. About 147 …

This early-stage trial tests a new drug called imetelstat combined with two standard chemotherapies for children and teens with acute myeloid leukemia, myelodysplastic syndrome, or juvenile myelomonocytic leukemia that has returned or not responded to treatment. The main goal is …

This study tests whether adding a radioactive drug (131I-MIBG) or a targeted pill (lorlatinib) to standard intensive therapy helps children and young adults with newly diagnosed high-risk neuroblastoma live longer without the cancer returning. About 750 participants aged 1 to 30 …

This study tests a home-based physical activity program designed for Hispanic and Latino teens and young adults who survived childhood cancer. Many survivors face long-term issues like weight gain and fatigue, and this program uses a Fitbit and social media to encourage more exer…

This study tests whether adding a chemotherapy drug (melphalan) injected directly into the eye can help treat a childhood eye cancer called retinoblastoma, especially when tumor seeds are floating in the eye fluid. About 26 children with newly diagnosed retinoblastoma will receiv…

This phase 3 trial tests whether xylitol dental wipes can reduce bloodstream infections in children with acute myeloid leukemia (AML). Xylitol, a natural sugar that limits mouth bacteria growth, is applied via wipes during chemotherapy. The study will compare infection rates betw…

This study looks at how well children with cancer are cared for at the end of life. Researchers will review medical records and talk to parents of about 1,190 children who have passed away. The goal is to understand what factors lead to better or worse care, so future families ca…

This study looks at how certain blood cell changes (called clonal hematopoiesis) after Hodgkin lymphoma treatment might be linked to later heart problems. Researchers will test blood samples from 190 survivors who received chemotherapy as children or young adults. The goal is to …

This study looks at the long-term health of people with Down syndrome who have been treated for acute leukemia. Researchers want to understand what chronic health problems survivors may face and what factors contribute to them. The goal is to create better follow-up care guidelin…

This study is a large registry that collects health information and leftover tumor or blood samples from up to 75,000 children and young adults with cancer. The goal is to track outcomes and gather data to help doctors find better ways to treat and care for these patients over ti…

This study collects stored cord blood from 300 children diagnosed with leukemia and checks for the same cancer mutations found in their tumor samples. Researchers want to understand how and when these mutations first appear before birth. The goal is to eventually develop a screen…

This pilot study is looking at 25 pairs of identical twins where only one twin has a childhood brain tumor. Researchers will collect blood and saliva samples to search for small genetic differences, called somatic mosaicism, that might explain why one twin got sick and the other …

This study follows over 1,100 children who were treated for germ cell tumors (a type of cancer). Researchers want to learn about long-term side effects like hearing loss and to analyze tumor DNA to better predict which children might have their cancer come back. Participants prov…