Sugar compound in dental wipes may shield kids with leukemia from deadly infections
NCT ID NCT07022678
First seen Jun 24, 2026 · Last updated Jul 17, 2026 · Updated 5 times
Summary
This phase 3 trial tests whether xylitol dental wipes can reduce bloodstream infections in children with acute myeloid leukemia (AML). Xylitol, a natural sugar that limits mouth bacteria growth, is applied via wipes during chemotherapy. The study will compare infection rates between children using xylitol wipes and those using wipes without xylitol, aiming to prevent bacteria from entering the bloodstream through the mouth.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- xylitol dental wipes
- What this could lead to
- If it works, this simple, low-cost approach could help prevent dangerous bloodstream infections in children with AML, reducing hospital stays and improving treatment outcomes.
- What could go wrong
- This is a phase 3 trial, but the effect may be modest or not statistically significant. Xylitol wipes are generally safe, but they won't eliminate all infection risks.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Albany Medical Center
RECRUITINGAlbany, New York, 12208, United States
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Alfred I duPont Hospital for Children
RECRUITINGWilmington, Delaware, 19803, United States
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Arkansas Children's Hospital
RECRUITINGLittle Rock, Arkansas, 72202-3591, United States
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Bronson Methodist Hospital
RECRUITINGKalamazoo, Michigan, 49007, United States
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Children's Healthcare of Atlanta - Arthur M Blank Hospital
RECRUITINGAtlanta, Georgia, 30329, United States
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's Hospital of Pittsburgh of UPMC
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
RECRUITINGGrand Rapids, Michigan, 49503, United States
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Dell Children's Medical Center of Central Texas
RECRUITINGAustin, Texas, 78723, United States
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East Tennessee Childrens Hospital
RECRUITINGKnoxville, Tennessee, 37916, United States
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Geisinger Medical Center
RECRUITINGDanville, Pennsylvania, 17822, United States
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Kaiser Permanente-Oakland
RECRUITINGOakland, California, 94611, United States
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Lurie Children's Hospital-Chicago
RECRUITINGChicago, Illinois, 60611, United States
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Medical City Dallas Hospital
RECRUITINGDallas, Texas, 75230, United States
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Montefiore Medical Center - Moses Campus
RECRUITINGThe Bronx, New York, 10467, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nemours Children's Clinic - Pensacola
RECRUITINGPensacola, Florida, 32504, United States
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Contact Email: •••••@•••••
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Nemours Children's Clinic-Jacksonville
RECRUITINGJacksonville, Florida, 32207, United States
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Nemours Children's Hospital
RECRUITINGOrlando, Florida, 32827, United States
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Norton Children's Hospital
RECRUITINGLouisville, Kentucky, 40202, United States
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ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
RECRUITINGToledo, Ohio, 43606, United States
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Providence Sacred Heart Medical Center and Children's Hospital
RECRUITINGSpokane, Washington, 99204, United States
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Rainbow Babies and Childrens Hospital
RECRUITINGCleveland, Ohio, 44106, United States
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Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
RECRUITINGDenver, Colorado, 80218, United States
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The Children's Hospital at TriStar Centennial
RECRUITINGNashville, Tennessee, 37203, United States
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UT Southwestern/Simmons Cancer Center-Dallas
RECRUITINGDallas, Texas, 75390, United States
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University of Kentucky/Markey Cancer Center
RECRUITINGLexington, Kentucky, 40536, United States
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University of Virginia Cancer Center
RECRUITINGCharlottesville, Virginia, 22908, United States
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Valley Children's Hospital
RECRUITINGMadera, California, 93636, United States
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