Children's Oncology Group

This large, completed Phase 3 trial aimed to see if adding a new combination of three chemotherapy drugs (vincristine, topotecan, and cyclophosphamide) to the standard five-drug treatment could improve survival for children and young adults with Ewing sarcoma that had not spread.…

This study tested a complex, multi-step treatment plan for children and young adults newly diagnosed with high-risk neuroblastoma, a serious childhood cancer. The goal was to see if it was possible and safe to combine intensive chemotherapy, a targeted radiation drug (MIBG), a st…

This study aimed to find the best chemotherapy treatment for very young children (under 3 years old) with newly diagnosed, high-risk brain tumors. It directly compared two intense drug combinations, one with a drug called methotrexate and one without, to see which was more effect…

This study tested a two-part treatment for children and young adults who developed a type of cancer (PTLD) after an organ transplant. The treatment combined a standard antibody drug (rituximab) with special immune cells trained to fight the virus linked to the cancer. The main go…

This study tested whether doctors could safely use lower doses of radiation to treat two types of rare brain tumors in children and young adults. The goal was to control the cancer while trying to reduce the long-term side effects of treatment, especially on thinking and learning…