Children's Oncology Group

This phase 3 trial investigates whether adding carboplatin and isotretinoin to standard radiation and chemotherapy improves outcomes for children and young adults with high-risk medulloblastoma, a fast-growing brain tumor. Participants receive radiation therapy along with several…

This trial studies whether giving a lower dose of radiation to the brain and spine, along with a smaller radiation boost to the tumor site, works as well as standard radiation when combined with chemotherapy in children aged 3–7 with newly diagnosed standard-risk medulloblastoma.…

This phase II trial studied how well surgery, chemotherapy, and radiation work in 188 children with newly diagnosed, low-stage lymphocyte predominant Hodgkin disease. The goal was to find effective treatments that minimize side effects. Patients received different therapies based…

This phase 3 trial tested how well combination chemotherapy with or without radiation therapy works in 395 children and young adults with newly diagnosed stage III or IV Wilms tumor. The goal was to see if adding radiation could improve the chance of staying cancer-free for 4 yea…

This study tested giving chemotherapy before surgery to children with Wilms tumor, a rare kidney cancer. The goal was to shrink tumors so surgeons could remove less kidney tissue, helping preserve kidney function. 249 children took part, and the approach aimed to reduce the need …

This phase 3 trial studied how well chemotherapy with or without radiation works after surgery for children with a type of kidney cancer called Wilms tumor. Over 800 children with low- or standard-risk disease took part. The goal was to see if less intensive treatment could still…

This large phase 3 trial enrolled over 9,000 children with newly diagnosed standard-risk B-ALL or localized B-LLy. Researchers tested different combinations and doses of chemotherapy drugs to see which worked best with the fewest side effects. The goal was to improve disease-free…

This study looked at whether giving chemotherapy after radiation helps children with a type of brain tumor called ependymoma. About 479 children aged 1 to 21 took part. Some received radiation alone, while others also got a combination of chemotherapy drugs. The goal was to see i…

This study tested a program to help children with acute lymphoblastic leukemia (ALL) take their daily chemotherapy medication (mercaptopurine) as prescribed during maintenance therapy. 570 children in remission were randomly assigned to either the intervention program or standard…

This pilot study tested a combination of rituximab (a targeted antibody) and specially trained immune cells (LMP-specific T-cells) in 18 children who developed a type of lymphoma after receiving a solid organ transplant. The goal was to see if this approach could effectively trea…

This study tested a very strong treatment plan for children newly diagnosed with high-risk neuroblastoma, a serious nerve cell cancer. The approach combined intensive chemotherapy, a radioactive drug called 131I-MIBG, and a stem cell transplant to try to kill more cancer cells. T…

This study tested whether adding a drug called topotecan to the standard 5-drug chemotherapy regimen improves outcomes for children and adults with Ewing sarcoma that hasn't spread. 642 participants were randomly assigned to receive either the standard treatment or the standard p…

This study looked at 91 children under 3 years old with aggressive brain tumors. It compared two intense chemotherapy plans, one with and one without methotrexate, followed by a stem cell transplant. The goal was to see which approach led to more complete tumor disappearance.

This phase 2 trial tested whether children with localized central nervous system germ cell tumors could safely receive lower doses of radiation after chemotherapy. The study enrolled 262 children and used response to chemotherapy to decide the radiation dose. The goal was to main…

This study tested whether a computer-based cognitive training program could help children with brain tumors who had radiation therapy. 45 children were randomly assigned to either an adaptive or non-adaptive training program. The goal was to see if the training could improve thin…

This study looked at how cancer and its treatment affect thinking, memory, emotions, and behavior in children and teens. Researchers collected information from tests and surveys over time to understand these effects. The goal was to learn more, not to test a new treatment.

This completed research study collected and stored tumor tissue, blood, and urine samples from 8,000 children and young adults with kidney tumors. The goal was to help scientists study DNA changes and find biomarkers that could improve understanding of these cancers. No treatment…

This study looked at nearly 4,000 childhood cancer survivors to see if their genes affect their risk of developing serious late complications like heart failure, stroke, bone damage, or a second cancer. Researchers compared survivors who had these problems with those who did not,…