Children's Oncology Group

This study looked at whether giving chemotherapy first, then using lower doses of radiation, could effectively control localized central nervous system germ cell tumors in children and teens. A total of 262 newly diagnosed patients received treatment tailored to how their tumor r…

This study tested a program to help children with acute lymphoblastic leukemia (ALL) take their daily chemotherapy pills more consistently. About 570 children in remission were assigned to either an educational program or an intensive support program. The goal was to see if extra…

This study tested a more intense treatment for children newly diagnosed with high-risk neuroblastoma, a serious nerve tissue cancer. The approach combined strong chemotherapy with a radioactive drug (131I-MIBG) to kill cancer cells, followed by a stem cell transplant to restore h…

This study looked at two different chemotherapy treatments for children under 3 with certain aggressive brain tumors. The goal was to see if adding a drug called methotrexate to the standard chemo before a stem cell transplant helps more tumors shrink or disappear. The trial invo…

This study tested a new treatment for children who developed a type of lymphoma after an organ transplant. The treatment combined a drug called rituximab with specially trained immune cells that target the virus causing the cancer. The goal was to see if this combination could wo…

This study looked at whether giving chemotherapy after surgery and radiation helps children and young adults (ages 1-21) with a newly diagnosed brain tumor called ependymoma. About 479 participants were split into groups: some got chemo after radiation, others did not. The goal w…

This study tested whether adding a new three-drug combination (vincristine, topotecan, cyclophosphamide) to the standard five-drug chemotherapy could improve outcomes for children and young adults with Ewing sarcoma that had not spread. A total of 642 participants were randomly a…

This study tested whether a computer-based cognitive training program could help children with brain tumors who had radiation therapy. 45 children were randomly assigned to either an adaptive or non-adaptive training program. The goal was to see if the training could improve thin…