New combo therapy shows promise for kids with Transplant-Related cancer
NCT ID NCT02900976
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested a combination of rituximab (a targeted antibody) and specially trained immune cells (LMP-specific T-cells) in 18 children who developed a type of lymphoma after receiving a solid organ transplant. The goal was to see if this approach could effectively treat the cancer while being safer than standard chemotherapy. The study was completed but stopped early, so results are limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Rituximab and LMP-specific T-cells
What this could lead to
If it works, this could offer a targeted treatment option for children with post-transplant lymphoma, potentially reducing the need for stronger chemotherapy.
What could go wrong
This was a very small pilot study (18 participants) that stopped early, so results are limited. The treatment may not work for everyone and could cause immune reactions or other side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030, United States
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C S Mott Children's Hospital
Ann Arbor, Michigan, 48109, United States
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Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, Georgia, 30329, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital of Alabama
Birmingham, Alabama, 35233, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, 15224, United States
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Children's Hospital of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Children's Mercy Hospitals and Clinics
Kansas City, Missouri, 64108, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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Loma Linda University Medical Center
Loma Linda, California, 92354, United States
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Lucile Packard Children's Hospital Stanford University
Palo Alto, California, 94304, United States
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Mattel Children's Hospital UCLA
Los Angeles, California, 90095, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032, United States
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Phoenix Childrens Hospital
Phoenix, Arizona, 85016, United States
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Primary Children's Hospital
Salt Lake City, Utah, 84113, United States
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Riley Hospital for Children
Indianapolis, Indiana, 46202, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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UCSF Medical Center-Mission Bay
San Francisco, California, 94158, United States
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UF Health Cancer Institute - Gainesville
Gainesville, Florida, 32610, United States
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UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
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UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390, United States
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University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136, United States
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University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, 55455, United States
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University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
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University of Nebraska Medical Center
Omaha, Nebraska, 68198, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
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University of Rochester
Rochester, New York, 14642, United States
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Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States