Children's Oncology Group

This study aims to find the best chemotherapy plan for patients newly diagnosed with intermediate-risk rhabdomyosarcoma, a rare cancer that mostly affects children and young adults. It will compare a shorter, more intense treatment to a longer, less intense treatment that include…

This study is for children and young adults newly diagnosed with T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LL). It will test if adding a targeted drug called daratumumab to standard chemotherapy helps patients stay cancer-free longer and impr…

This study aims to see if a new type of imaging scan, called 18F-MFBG PET, is as good as the current standard scan (123I-MIBG) at finding and measuring tumors in children with newly diagnosed, high-risk neuroblastoma. About 84 participants will receive both types of scans during …

This study is testing whether special dental wipes containing xylitol, a natural sugar, can prevent serious bloodstream infections in children and young adults being treated for acute myeloid leukemia (AML). Chemotherapy weakens the immune system, making patients vulnerable to in…

This study aims to understand what affects the quality of end-of-life care for children with cancer. Researchers will review medical records and survey bereaved parents to identify patterns and risk factors. The goal is to create a model that helps identify children who might rec…