Children's Oncology Group

This study tests whether adding daratumumab, a drug that helps the immune system attack cancer cells, to standard chemotherapy can improve outcomes for children and young adults with newly diagnosed T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma. About 1,700…

This study compares two chemotherapy approaches for people up to age 50 with newly diagnosed intermediate-risk rhabdomyosarcoma, a type of muscle cancer. One group gets a higher dose of chemo over a shorter time, while the other gets a lower dose over a longer time plus extra mai…

This study tests whether a new type of scan (18F-MFBG PET/CT or PET/MRI) can find neuroblastoma tumors as well as the current standard scan (123I-MIBG). About 84 children and adults with newly diagnosed, high-risk neuroblastoma will receive both scans at different times. The goal…

This study tests whether dental wipes containing xylitol, a natural sugar that limits bacteria growth in the mouth, can reduce bloodstream infections in children and young adults (ages 1-25) with acute myeloid leukemia (AML). Participants will use either xylitol wipes or plain wi…

This study looks at how access to care and family interactions with the healthcare system affect the quality of end-of-life care for children with cancer. Researchers will collect data from about 1,190 children who have passed away and their parents. The goal is to find ways to i…