Children's Oncology Group

This study tests a drug called enasidenib in children and young adults (ages 2 to 21) with acute myeloid leukemia that has returned or not responded to treatment. Participants must have a specific genetic change (IDH2 mutation). The goal is to see if the drug is safe and how the …

This study tests whether adding levocarnitine, a natural nutrient, to standard chemotherapy can prevent severe liver damage in teens and young adults (ages 15-39) with leukemia or lymphoma. Liver toxicity from the chemotherapy drug asparaginase often forces treatment delays, whic…

This study looks at whether a wearable device called Optune is safe and practical for children with aggressive brain tumors. In one group, kids with recurrent high-grade glioma or ependymoma use the device alone. In another group, children with newly diagnosed DIPG use the device…

This study tests whether adding a drug called vinorelbine to standard chemotherapy can better control high-risk rhabdomyosarcoma, a cancer that often returns or spreads. About 118 children and young adults will receive either the standard treatment or the new combination, followe…

This study tests a daily pill called bosutinib in children with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). It includes children who are newly diagnosed or whose cancer has stopped responding to other treatments. The goal is to find the best dose and see …

This study is for children and young adults up to age 30 with newly diagnosed stage III or IV Wilms tumor, a type of kidney cancer. It tests whether combining several chemotherapy drugs, with or without radiation therapy, can better prevent the cancer from coming back. The goal i…

This study tests whether giving lower doses of radiation and chemotherapy to children with a specific type of brain tumor (WNT medulloblastoma) can still cure the cancer while reducing long-term side effects like learning problems and hormone issues. About 45 children aged 3 to 2…

This study looks at how well surgery alone, or with chemotherapy and possibly radiation, works for children with newly diagnosed, early-stage lymphocyte predominant Hodgkin disease (LPHD). About 188 children with stage I or II LPHD are being treated and followed to see if they st…

This study tests a new oral drug (revumenib) combined with chemotherapy in infants and young children up to 6 years old whose leukemia has returned or not responded to treatment. The leukemia must have a specific genetic change called KMT2A rearrangement. The goal is to see if th…

This study tests whether adding two chemotherapy drugs (irinotecan and temozolomide) to the standard immunotherapy regimen (dinutuximab, GM-CSF, and isotretinoin) can safely prevent high-risk neuroblastoma from returning after intensive initial therapy. About 41 children and youn…

This study tests different combinations of chemotherapy drugs in children and young adults with liver cancer (hepatoblastoma or hepatocellular carcinoma). The goal is to see which combinations work best alongside surgery to stop tumors from growing or spreading. About 537 partici…

This trial was designed to test the safety and best dose of the drug revumenib in children with certain types of leukemia after they had a stem cell transplant. The goal was to see if revumenib could help keep the cancer from coming back. However, the study was withdrawn before a…

This study tests a drug called nirogacestat in children and teens with desmoid tumors that have grown despite treatment and cannot be surgically removed. The goal is to see if the drug can stop or slow tumor growth and to check for side effects. About 31 participants aged 1 to 18…

This early-stage study tests a treatment made from a child's own immune cells, modified to recognize and attack a protein called HER2 found on ependymoma tumors. The goal is to see if it is safe and feasible for children whose tumor has returned or not responded to standard thera…

This early-phase study tests a cancer vaccine called SurVaxM in 35 children with brain tumors that have come back or are hard to treat. The vaccine is designed to teach the body's immune system to find and destroy tumor cells carrying a protein called survivin. The goal is to see…

This study tests a new treatment for people newly diagnosed with a type of leukemia called acute promyelocytic leukemia (APL). Instead of standard high-dose chemotherapy that can harm the heart, the treatment uses two drugs—tretinoin and arsenic trioxide—to stop cancer cells from…

This study tests whether adding eflornithine (DFMO) to a standard chemo-immunotherapy regimen (irinotecan, temozolomide, and dinutuximab) helps children whose neuroblastoma has returned or stopped responding to treatment. About 94 children will be randomly assigned to receive the…

This early-phase trial is testing a drug called flotetuzumab in children, adolescents, and young adults whose acute myeloid leukemia (AML) has returned or not responded to standard treatment. The drug works by helping the body's immune cells recognize and attack leukemia cells. T…

This study looks at whether children with chronic myeloid leukemia (CML) who have had very low disease levels for at least two years can safely stop taking their daily targeted therapy (tyrosine kinase inhibitors). The goal is to see if they can stay in remission without medicati…

This study looks at children, teens, and young adults with acute leukemia or myelodysplastic syndrome who need a stem cell transplant. It compares two donor types: a partially matched family donor versus a fully matched unrelated donor. The goal is to see which option leads to fe…

This study looks at children and teens with a specific type of leukemia called Philadelphia chromosome-positive ALL. It tests whether a targeted drug called imatinib works as well with a milder chemotherapy regimen as it does with a stronger one, but with fewer side effects. The …

This study tests whether adjusting treatment based on each child's tumor biology and how the tumor responds can reduce side effects while still controlling the disease. About 621 children with non-high-risk neuroblastoma are being observed or given tailored therapy instead of sta…

This study looks at how well chemotherapy drugs (vincristine, dactinomycin, doxorubicin) with or without radiation work after surgery for children with a type of kidney cancer called Wilms tumor. Some children with very low-risk tumors may only need observation after surgery. The…

This study tests whether adding three drugs (vincristine, irinotecan, and regorafenib) to standard chemotherapy helps people with metastatic Ewing sarcoma live longer without the cancer growing. About 437 participants aged 1 to 50 with newly diagnosed, spread cancer will be rando…

This study tests a drug called larotrectinib in children and young adults with certain cancers that have a specific genetic change called a TRK fusion. The goal is to see if the drug can shrink tumors or control the cancer. About 33 participants with solid tumors or relapsed leuk…

This large phase 3 study is testing different combinations and doses of chemotherapy drugs in over 9,000 children and young adults newly diagnosed with standard-risk B-cell acute lymphoblastic leukemia or localized B-cell lymphoblastic lymphoma. The goal is to find which treatmen…

This study tests whether a probiotic called Lactobacillus plantarum can prevent acute graft-versus-host disease (GvHD) in the gut of children receiving donor stem cell transplants. About 173 children with blood cancers or other conditions will take the probiotic or a placebo. The…

This study tests whether memantine, a drug used for Alzheimer's, can help protect memory and thinking in children ages 4-17 who need brain radiation for central nervous system tumors. About 192 participants will receive either memantine or a placebo during and after radiation. Th…

This study follows 1,200 children with cancer to understand how the disease and its treatments affect learning, memory, emotions, and behavior. Researchers collect data from tests over time, but no new treatment is given. The goal is to improve future care by identifying challeng…

This study looks at children born with birth defects who later develop cancer, aiming to find shared genetic causes. Researchers will analyze DNA from 1,000 children and their parents. The goal is to improve cancer risk monitoring and care for children with birth defects.

This research study looks at tumor samples from up to 10,000 children newly diagnosed with neuroblastoma or related tumors. Scientists examine the samples for genetic markers and other features to better understand the disease and predict how it may respond to treatment. The goal…

This study follows children and teens who have had cancer or a stem cell transplant to see how they do over many years. Researchers collect health information to understand long-term side effects of treatment. The goal is to find ways to reduce problems and improve quality of lif…

This study looks at whether a special program using a mobile app and social media can help teens and young adults who survived childhood cancer become more physically active. About 387 survivors will either use the full program or just a fitness tracker alone. The goal is to see …

This study creates a large registry to collect information from nearly 58,000 children diagnosed with cancer or similar conditions in the U.S. and Canada. The goal is to help researchers study patterns, causes, and characteristics of childhood cancers. Parents provide details abo…

This study looks at genetic changes in children with a rare muscle cancer called rhabdomyosarcoma. Researchers will compare DNA from the child and both parents to find new gene mutations linked to the disease. The goal is to better understand what causes the cancer and how it may…

This study follows nearly 4,000 childhood cancer survivors to understand why some develop serious late effects like heart problems, stroke, or new cancers years after treatment. Researchers are looking at genes and other factors to identify those at highest risk. The goal is to i…

This study looks at how worried or anxious parents feel about money while their child is being treated for acute lymphoblastic leukemia. Researchers will track these feelings over time and see what factors, like income or hospital policies, affect them. About 100 parents will tak…

This study tracks how the immune systems of 549 children, teens, and young adults with cancer respond to COVID-19 vaccination. Cancer and its treatments can weaken immunity, so researchers want to see if factors like vaccine type, timing, and booster doses affect protection. The …

This pilot study looks at whether lab data from hospital electronic health records can be sent automatically to research databases, instead of being entered by hand. Researchers will test this process at multiple sites to see if it is efficient and accurate. The goal is to make c…

This study looks at the long-term health problems that can appear years after treatment for high-risk neuroblastoma, a type of childhood cancer. Researchers will follow 376 survivors to track issues like organ damage, growth problems, and thinking difficulties. The goal is to fin…

This study compares a new dosing method for the cancer drug vincristine in infants and young children to the standard method used in older children. The goal is to see if the new approach gives similar drug levels in the blood with fewer side effects. About 83 children up to 12 y…

This study looks at how inherited genes may make some children more likely to develop Langerhans cell histiocytosis (LCH), a rare disease where immune cells grow out of control. Researchers will analyze DNA from 647 patients and their parents to find gene changes linked to LCH. T…