Children's Oncology Group

This study is testing a new treatment for a specific type of leukemia called acute promyelocytic leukemia (APL). The goal is to cure the disease using a combination of two drugs—arsenic trioxide and tretinoin—while avoiding or reducing the use of standard chemotherapy drugs that …

This study is for children whose high-risk neuroblastoma has come back or stopped responding to initial treatment. It tests whether adding a pill called eflornithine (DFMO) to a standard combination of chemotherapy and immunotherapy works better. The goal is to see if the new com…

This large study aims to determine the best type of donor for stem cell transplants in children and young adults with high-risk leukemia or myelodysplastic syndrome (MDS). It directly compares transplants from a partially matched family member (haploidentical) to those from a ful…

This early-stage trial is testing a new immunotherapy drug called flotetuzumab in children, teens, and young adults whose acute myeloid leukemia (AML) has come back or hasn't responded to other treatments. The main goals are to find the safest dose and understand the side effects…

This trial is testing a wearable medical device called Optune for children with aggressive brain tumors. The device uses low-intensity electric fields to try to slow or stop tumor growth. The study has two parts: one for kids whose tumors have come back, and another for kids newl…

This study is testing whether adding two chemotherapy drugs to a standard immunotherapy regimen is safe and feasible for children and young adults with high-risk neuroblastoma. The treatment is given after patients have already completed intensive initial therapy, including stem …

This trial is testing whether adding two new drugs, irinotecan and regorafenib, to standard chemotherapy works better for young patients with Ewing sarcoma that has spread. It aims to see if this combination helps patients live longer without their cancer returning. The study is …

This study is testing whether lower doses of radiation to the brain and spine, along with reduced chemotherapy, can still effectively treat children with a specific type of brain tumor called WNT-driven medulloblastoma. The goal is to maintain a high cure rate while significantly…

This study is testing a drug called bosutinib for children with a specific type of leukemia called Philadelphia chromosome-positive chronic myeloid leukemia (CML). It aims to find the right dose for kids and see how safe and effective it is, both for newly diagnosed patients and …

This study compares two chemotherapy combinations for children and young adults with high-risk rhabdomyosarcoma, a rare and aggressive muscle cancer. Researchers want to see if adding a drug called vinorelbine to standard treatment helps keep the cancer from returning better than…

This study is testing whether children and young adults with a specific type of chronic leukemia can safely stop their daily medication and stay in remission. Participants who have been in a very deep remission for at least two years will stop taking their pills under close docto…

This study is testing a cancer vaccine called SurVaxM in children and young adults with aggressive brain tumors that have come back or progressed. The vaccine is designed to teach the body's immune system to find and destroy cancer cells that carry a specific protein called survi…

This study is testing a drug called enasidenib in children and young adults with a specific type of acute myeloid leukemia (AML) that has come back or not responded to standard chemotherapy. The goal is to see if the drug is safe for children and how their bodies process it. The …

This study is testing a new treatment plan for babies and young children with a lower-risk form of neuroblastoma, a childhood cancer. The goal is to see if carefully watching certain tumors first, instead of starting chemotherapy right away, is safe and can avoid unnecessary side…

This study is testing different combinations of chemotherapy drugs, with or without radiation therapy, to find the best way to treat children with advanced Wilms tumor, a type of kidney cancer. It aims to improve long-term survival without the cancer coming back. The treatment pl…

This large study is testing whether some children with early-stage Wilms tumor, a common childhood kidney cancer, can safely avoid chemotherapy after surgery. For 808 children, it compares standard chemotherapy drugs (vincristine, dactinomycin, and doxorubicin) with or without ra…

This large study aimed to find out if adding chemotherapy after surgery and targeted radiation works better than surgery and radiation alone for children and young adults (ages 1-21) newly diagnosed with a brain tumor called ependymoma. It tested whether this extra 'maintenance' …

This large international trial aims to find the best combinations of chemotherapy drugs and surgery to treat children and young adults with liver cancer (hepatoblastoma or hepatocellular carcinoma). It tests different treatment plans based on how severe the cancer is, with the go…

This early-stage trial is testing a new personalized treatment for children with ependymoma, a type of brain tumor that has come back or stopped responding to standard care. Doctors take a child's own immune cells, modify them in a lab to recognize and attack the tumor, and then …

This trial is for children and young adults with a specific, aggressive type of leukemia (Ph+ ALL). It tests whether a standard chemotherapy regimen works as well as a stronger one when both are given with the targeted drug imatinib, aiming to maintain high cure rates while reduc…

This study is testing a targeted drug called larotrectinib in children and young adults (up to age 30) with specific types of cancer. The cancers must have a rare genetic change called a TRK fusion. The goal is to see if the drug can shrink tumors or control leukemia before other…

This study tested a comprehensive support program to help children with acute lymphoblastic leukemia (ALL) take their daily oral chemotherapy medication more consistently. It compared a high-tech program with smart pill bottles and text reminders against standard education alone.…

This study is for children newly diagnosed with early-stage lymphocyte predominant Hodgkin disease (LPHD), a type of cancer. The main goal is to see if surgery alone can cure children whose cancer was completely removed, avoiding chemotherapy and radiation. For children who need …

This study is testing whether adding a new oral drug called revumenib to standard chemotherapy is safe and effective for infants and young children with a specific, high-risk type of leukemia that has come back or hasn't responded to previous treatments. The trial aims to find th…

This study is testing a new way to calculate the dose of the cancer drug vincristine for infants and very young children. The goal is to give them drug levels in their blood that are similar to older children, who use a standard dosing method, while trying to reduce severe side e…

This study is testing an oral medication called nirogacestat in children and adolescents with desmoid tumors that are growing and cannot be removed by surgery. The main goals are to see if the drug can stop the tumors from progressing, to check how safe it is, and to understand h…

This study is testing whether a specific probiotic (Lactobacillus plantarum) can prevent a serious complication called acute graft-versus-host disease (GvHD) in children, teens, and young adults getting a stem cell transplant from a donor for cancers like leukemia or lymphoma. Ab…

This study is testing whether a home computer training program can help improve thinking skills in children who have had radiation treatment for a brain tumor. It compares two types of computer games—one that adjusts to the child's skill level and one that does not—to see which m…

This study is testing whether a drug called memantine can help protect memory, attention, and other thinking skills in children and teenagers who need radiation therapy for brain tumors. Radiation can sometimes harm these cognitive functions. Researchers are comparing memantine t…

This study is testing a mobile health program designed to help young people who have survived childhood cancer become more physically active. It compares a full program—which includes a Fitbit, personalized goal setting, and a social media support group—against just wearing a Fit…

This study aims to collect and analyze tumor tissue, blood, and bone marrow samples from up to 10,000 children newly diagnosed with neuroblastoma, a type of childhood cancer. Researchers will study these samples in a lab to identify specific biological markers (biomarkers) in the…

This study is testing whether hospitals can automatically transfer laboratory test results from their electronic health records into clinical trial databases. Researchers are comparing this automated approach with traditional manual data entry to see if it's more accurate and eff…

This study aims to understand the genetic factors that might contribute to two types of childhood muscle cancer, called rhabdomyosarcoma. Researchers are collecting saliva samples from children diagnosed with this cancer and both of their parents to look for inherited genetic cha…

This study aims to understand why some childhood cancer survivors develop serious health problems years after treatment ends, such as heart failure, bone damage, stroke, or new cancers. Researchers are comparing survivors who developed these complications with those who did not, …

This study aims to measure and understand the financial stress and worry parents experience while their child is being treated for acute lymphoblastic leukemia (ALL). Researchers will survey 100 parents at different points during their child's treatment to see how money worries c…

This study aims to understand why some children develop Langerhans cell histiocytosis (LCH), a rare disorder where immune cells build up in the body. Researchers are analyzing DNA from children with LCH and their parents to identify inherited genetic variations that might increas…

This study created a large registry to collect information about children with cancer across the United States and Canada. Researchers ask parents to share details about their child's diagnosis and family background to build a comprehensive database. The goal is to help scientist…

This study aims to understand why children born with birth defects have a higher risk of developing cancer. Researchers will analyze the DNA of children who have both a birth defect and cancer, along with their parents, to look for shared genetic factors. The goal is to uncover t…

This study aims to understand how well the COVID-19 vaccine works in children, teens, and young adults who have cancer. Researchers are observing about 550 participants who are getting vaccinated during or after their cancer treatment. They will check blood samples over two years…

This study aims to understand how cancer and its treatments affect children's learning, memory, behavior, and emotional well-being over time. It follows 1,200 children and adolescents with cancer, assessing them at 9 months, 30 months, and 5 years after diagnosis. The goal is to …

This study aims to understand the long-term health problems that can occur in people who survived high-risk neuroblastoma as children. Researchers are following 376 survivors who were diagnosed after the year 2000 and finished their main cancer treatments at least two years ago. …