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New drug combo aims to boost Radiation's punch against childhood brain tumors

NCT ID NCT06894979

Ongoing Disease control Sponsor: Children's Oncology Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This study tests a new drug called AZD1390 given alongside radiation therapy for children with aggressive brain tumors (high-grade glioma, DIPG, or DMG). The drug blocks cancer cells from repairing damage caused by radiation, potentially making treatment more effective. About 54 children will take part to find the safest dose and see if the combination helps shrink tumors or slow their growth.

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Conditions

The condition(s) this trial relates to.

astrocytoma (excluding glioblastoma) childhood astrocytic tumor diffuse intrinsic pontine glioma diffuse midline glioma, H3 K27M-mutant glioblastoma malignant glioma pediatric high-grade glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHILDHOOD ASTROCYTOMA CHILDHOOD DIFFUSE INTRINSIC PONTINE GLIOMA CHILDHOOD DIFFUSE MIDLINE GLIOMA CHILDHOOD GLIOBLASTOMA CHILDHOOD MALIGNANT GLIOMA

Contacts and locations

Locations

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas, 77030, United States

  • C S Mott Children's Hospital

    Ann Arbor, Michigan, 48109, United States

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital

    Atlanta, Georgia, 30329, United States

  • Children's Hospital Colorado

    Aurora, Colorado, 80045, United States

  • Children's Hospital Los Angeles

    Los Angeles, California, 90027, United States

  • Children's Hospital of Alabama

    Birmingham, Alabama, 35233, United States

  • Children's Hospital of Orange County

    Orange, California, 92868, United States

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Hospital of Pittsburgh of UPMC

    Pittsburgh, Pennsylvania, 15224, United States

  • Children's National Medical Center

    Washington D.C., District of Columbia, 20010, United States

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

  • Lurie Children's Hospital-Chicago

    Chicago, Illinois, 60611, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

    New York, New York, 10032, United States

  • Phoenix Childrens Hospital

    Phoenix, Arizona, 85016, United States

  • Riley Hospital for Children

    Indianapolis, Indiana, 46202, United States

  • Saint Jude Children's Research Hospital

    Memphis, Tennessee, 38105, United States

  • Seattle Children's Hospital

    Seattle, Washington, 98105, United States

  • UCSF Medical Center-Mission Bay

    San Francisco, California, 94158, United States

  • UMC Cancer Center / UMC Health System

    Lubbock, Texas, 79415, United States

  • University of Minnesota/Masonic Cancer Center

    Minneapolis, Minnesota, 55455, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.