Can genes explain why some kids with birth defects develop cancer?
NCT ID NCT05071859
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at 1,000 children who have both a birth defect and cancer, along with their parents. Researchers will analyze DNA from saliva and blood samples to find genetic changes that might explain why these conditions occur together. The goal is to improve cancer risk management for children born with anomalies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could reveal genetic causes linking birth defects to childhood cancer, leading to better screening and risk management for affected children.
What could go wrong
This is an observational study, not a treatment trial. It may not find clear genetic links, and results may take years to translate into clinical practice.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Baylor College of Medicine/ Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030, United States