Can genes explain why some kids with birth defects develop cancer?

NCT ID NCT05071859

Ongoing Knowledge-focused Sponsor: Children's Oncology Group Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at 1,000 children who have both a birth defect and cancer, along with their parents. Researchers will analyze DNA from saliva and blood samples to find genetic changes that might explain why these conditions occur together. The goal is to improve cancer risk management for children born with anomalies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could reveal genetic causes linking birth defects to childhood cancer, leading to better screening and risk management for affected children.
What could go wrong: This is an observational study, not a treatment trial. It may not find clear genetic links, and results may take years to translate into clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

childhood malignant neoplasm Congenital Abnormalities neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONGENITAL ANOMALY PEDIATRIC CANCER

Contacts and locations

Locations

Baylor College of Medicine/ Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States

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