New cocktail of cancer drugs shows promise for Tough-to-Treat sarcoma
NCT ID NCT06820957
First seen Jun 25, 2026 · Last updated Jul 30, 2026 · Updated 3 times
Summary
This study tests whether adding three drugs (vincristine, irinotecan, and regorafenib) to standard chemotherapy can help people with Ewing sarcoma that has spread. About 437 participants will receive either the new combo or standard treatment. The goal is to see if the new approach delays cancer growth and improves survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Vincristine, irinotecan, regorafenib, doxorubicin, cyclophosphamide, ifosfamide, etoposide
- What this could lead to
- If successful, this could offer a more effective treatment option for people with metastatic Ewing sarcoma, potentially improving survival rates.
- What could go wrong
- This is an early-to-mid-stage trial, so the new drug combo may not work better than standard treatment. Side effects from the multiple chemotherapy drugs could be severe.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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BI-LO Charities Children's Cancer Center
Greenville, South Carolina, 29605, United States
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Children's Hospital of Alabama
Birmingham, Alabama, 35233, United States
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East Tennessee Childrens Hospital
Knoxville, Tennessee, 37916, United States
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Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826, United States
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Lurie Children's Hospital-Chicago
Chicago, Illinois, 60611, United States
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NYU Langone Hospital - Long Island
Mineola, New York, 11501, United States
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OSF Children's Hospital of Illinois
Peoria, Illinois, 61637, United States
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Prisma Health Richland Hospital
Columbia, South Carolina, 29203, United States
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Saint Christopher's Hospital for Children
Philadelphia, Pennsylvania, 19134, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Experimental drug shows promise for Tough-to-Treat bone cancers
- New drug cocktail aims to keep childhood cancers at bay
- New hope for rare bone cancer: targeted drug added to chemo in major trial
- New drug BTX-A51 tested in rare sarcomas
- Radical new schedule aims to cure High-Risk ewing sarcoma
- Cancer drug regorafenib tested to halt bone sarcoma spread