New hope for kids with rare lung cancer: tailored chemo trial launches

NCT ID NCT06647953

Recruiting now Disease control Sponsor: Children's Oncology Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial studies the best way to treat pleuropulmonary blastoma (PPB), a rare childhood lung tumor. For type I PPB, it compares surgery alone to surgery plus chemotherapy. For types II and III, it tests adding the drug topotecan to standard chemotherapy. About 110 children up to age 21 will take part to see which approach works better and causes fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: chemotherapy (ifosfamide, vincristine, dactinomycin, doxorubicin, topotecan)
What this could lead to: If successful, this could establish the best treatment approach for each type of PPB, potentially reducing the need for chemotherapy in some children and improving outcomes in others.
What could go wrong: This is an early-phase trial with only 110 participants, so results may not apply to all patients. Chemotherapy side effects can be serious, and adding topotecan may increase risks without clear benefit.

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Conditions

The condition(s) this trial relates to.

pleuropulmonary blastoma pleuropulmonary blastoma type 1 pleuropulmonary blastoma type 2 pleuropulmonary blastoma type 3

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PLEUROPULMONARY BLASTOMA

Contacts and locations

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Locations

Albany Medical Center
RECRUITING

Albany, New York, 12208, United States
Alfred I duPont Hospital for Children
RECRUITING

Wilmington, Delaware, 19803, United States
Arkansas Children's Hospital
RECRUITING

Little Rock, Arkansas, 72202-3591, United States
Arnold Palmer Hospital for Children
RECRUITING

Orlando, Florida, 32806, United States
BI-LO Charities Children's Cancer Center
RECRUITING

Greenville, South Carolina, 29605, United States
Bronson Methodist Hospital
RECRUITING

Kalamazoo, Michigan, 49007, United States
C S Mott Children's Hospital
RECRUITING

Ann Arbor, Michigan, 48109, United States
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
RECRUITING

Québec, G1V 4G2, Canada
Centre Hospitalier Universitaire Sainte-Justine
RECRUITING

Montreal, Quebec, H3T 1C5, Canada
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
Children's Healthcare of Atlanta - Arthur M Blank Hospital
RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Children's Hospital New Orleans
RECRUITING

New Orleans, Louisiana, 70118, United States
Children's Hospital and Medical Center of Omaha
RECRUITING

Omaha, Nebraska, 68114, United States
Children's Hospital of Alabama
RECRUITING

Birmingham, Alabama, 35233, United States

Contact Email: •••••@•••••
Children's Hospital of Michigan
RECRUITING

Detroit, Michigan, 48201, United States

Contact Email: •••••@•••••
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••
Children's Hospital of Pittsburgh of UPMC
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Children's Hospital of San Antonio
RECRUITING

San Antonio, Texas, 78207, United States
Children's Hospital of The King's Daughters
RECRUITING

Norfolk, Virginia, 23507, United States

Contact Email: •••••@•••••
Children's Hospitals and Clinics of Minnesota - Minneapolis
RECRUITING

Minneapolis, Minnesota, 55404, United States
Children's Mercy Hospitals and Clinics
RECRUITING

Kansas City, Missouri, 64108, United States

Contact Email: •••••@•••••
Children's National Medical Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States

Contact Email: •••••@•••••
Cook Children's Medical Center
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Email: •••••@•••••
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Covenant Children's Hospital
RECRUITING

Lubbock, Texas, 79410, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Dayton Children's Hospital
RECRUITING

Dayton, Ohio, 45404, United States
Dell Children's Medical Center of Central Texas
RECRUITING

Austin, Texas, 78723, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Golisano Children's Hospital of Southwest Florida
RECRUITING

Fort Myers, Florida, 33908, United States
Hospital for Sick Children
RECRUITING

Toronto, Ontario, M5G 1X8, Canada
IWK Health Centre
RECRUITING

Halifax, Nova Scotia, B3K 6R8, Canada

Contact Email: •••••@•••••
Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States
Kaiser Permanente-Oakland
RECRUITING

Oakland, California, 94611, United States
Loma Linda University Medical Center
RECRUITING

Loma Linda, California, 92354, United States
Lurie Children's Hospital-Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Methodist Children's Hospital of South Texas
RECRUITING

San Antonio, Texas, 78229, United States
Montefiore Medical Center - Moses Campus
RECRUITING

The Bronx, New York, 10467, United States
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Nemours Children's Clinic - Pensacola
RECRUITING

Pensacola, Florida, 32504, United States

Contact Email: •••••@•••••
Nemours Children's Clinic-Jacksonville
RECRUITING

Jacksonville, Florida, 32207, United States
Nemours Children's Hospital
RECRUITING

Orlando, Florida, 32827, United States
New York Medical College
RECRUITING

Valhalla, New York, 10595, United States
Nicklaus Children's Hospital
RECRUITING

Miami, Florida, 33155, United States
Norton Children's Hospital
RECRUITING

Louisville, Kentucky, 40202, United States

Contact Email: •••••@•••••
Oregon Health and Science University
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States

Contact Email: •••••@•••••
Phoenix Childrens Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
Primary Children's Hospital
RECRUITING

Salt Lake City, Utah, 84113, United States
Providence Sacred Heart Medical Center and Children's Hospital
RECRUITING

Spokane, Washington, 99204, United States
Rainbow Babies and Childrens Hospital
RECRUITING

Cleveland, Ohio, 44106, United States
Riley Hospital for Children
RECRUITING

Indianapolis, Indiana, 46202, United States
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
RECRUITING

Denver, Colorado, 80218, United States

Contact Email: •••••@•••••
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
RECRUITING

New Brunswick, New Jersey, 08903, United States
Saint Joseph's Hospital/Children's Hospital-Tampa
RECRUITING

Tampa, Florida, 33607, United States
Saint Joseph's Regional Medical Center
RECRUITING

Paterson, New Jersey, 07503, United States
Saint Jude Children's Research Hospital
RECRUITING

Memphis, Tennessee, 38105, United States

Contact Email: •••••@•••••
Saint Vincent Hospital Cancer Center Green Bay
RECRUITING

Green Bay, Wisconsin, 54301, United States
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
Seattle Children's Hospital
NOT_YET_RECRUITING

Seattle, Washington, 98105, United States
The Children's Hospital at TriStar Centennial
RECRUITING

Nashville, Tennessee, 37203, United States
The Montreal Children's Hospital of the MUHC
RECRUITING

Montreal, Quebec, H3H 1P3, Canada

Contact Email: •••••@•••••
The Steven and Alexandra Cohen Children's Medical Center of New York
RECRUITING

New Hyde Park, New York, 11040, United States
UCSF Benioff Children's Hospital Oakland
RECRUITING

Oakland, California, 94609, United States
UCSF Medical Center-Mission Bay
RECRUITING

San Francisco, California, 94158, United States

Contact Email: •••••@•••••
UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
University of Iowa/Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kentucky/Markey Cancer Center
NOT_YET_RECRUITING

Lexington, Kentucky, 40536, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact Email: •••••@•••••
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States

Contact Email: •••••@•••••
Valley Children's Hospital
RECRUITING

Madera, California, 93636, United States

Contact Email: •••••@•••••
Vanderbilt University/Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••

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