New trial seeks best chemo strategy for childhood muscle cancer

NCT ID NCT07466316

Recruiting now Disease control Sponsor: Children's Oncology Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study compares two chemotherapy plans for people with newly diagnosed intermediate-risk rhabdomyosarcoma, a type of muscle cancer. One group gets a higher dose of chemo over a shorter time, while the other gets a lower dose over a longer time plus extra maintenance drugs. The goal is to see which approach works better and has fewer side effects. About 342 participants up to age 50 will take part.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

rhabdomyosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHABDOMYOSARCOMA

Contacts and locations

Show contact details

Locations

Albany Medical Center
RECRUITING

Albany, New York, 12208, United States
Alfred I duPont Hospital for Children
RECRUITING

Wilmington, Delaware, 19803, United States
Beacon Kalamazoo
RECRUITING

Kalamazoo, Michigan, 49048, United States
Bronson Battle Creek
RECRUITING

Battle Creek, Michigan, 49017, United States
Bronson Methodist Hospital
RECRUITING

Kalamazoo, Michigan, 49007, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores
SUSPENDED

Norton Shores, Michigan, 49444, United States
Children's Healthcare of Atlanta - Arthur M Blank Hospital
RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital Medical Center of Akron
RECRUITING

Akron, Ohio, 44308, United States
Children's Hospital of Orange County
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••
Children's Hospital of Pittsburgh of UPMC
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Children's Hospital of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Children's Mercy Hospitals and Clinics
RECRUITING

Kansas City, Missouri, 64108, United States

Contact Email: •••••@•••••
Connecticut Children's Medical Center
RECRUITING

Hartford, Connecticut, 06106, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
RECRUITING

Saint Joseph, Michigan, 49085, United States
Corewell Health Lakeland Hospitals - Niles Hospital
RECRUITING

Niles, Michigan, 49120, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
RECRUITING

Saint Joseph, Michigan, 49085, United States
Corewell Health Reed City Hospital
RECRUITING

Reed City, Michigan, 49677, United States
Driscoll Children's Hospital
RECRUITING

Corpus Christi, Texas, 78411, United States
East Tennessee Childrens Hospital
RECRUITING

Knoxville, Tennessee, 37916, United States
Inova Fairfax Hospital
RECRUITING

Falls Church, Virginia, 22042, United States
Kaiser Permanente-Oakland
RECRUITING

Oakland, California, 94611, United States
Legacy Emanuel Children's Hospital
RECRUITING

Portland, Oregon, 97227, United States
Maine Children's Cancer Program
RECRUITING

Scarborough, Maine, 04074, United States

Contact Email: •••••@•••••
MaineHealth Cancer Care Center of York County
RECRUITING

Sanford, Maine, 04073, United States
MaineHealth Coastal Cancer Treatment Center
RECRUITING

Bath, Maine, 04530, United States
MaineHealth Maine Medical Center - Portland
RECRUITING

Portland, Maine, 04102, United States

Contact Email: •••••@•••••
MaineHealth Maine Medical Center- Scarborough
RECRUITING

Scarborough, Maine, 04074, United States

Contact Email: •••••@•••••
Mary Bridge Children's Hospital and Health Center
RECRUITING

Tacoma, Washington, 98405, United States

Contact Email: •••••@•••••
Mattel Children's Hospital UCLA
RECRUITING

Los Angeles, California, 90095, United States
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
RECRUITING

Hollywood, Florida, 33021, United States
Methodist Children's Hospital of South Texas
RECRUITING

San Antonio, Texas, 78229, United States
Mission Hospital
RECRUITING

Asheville, North Carolina, 28801, United States
Montefiore Medical Center - Moses Campus
RECRUITING

The Bronx, New York, 10467, United States
Munson Medical Center
RECRUITING

Traverse City, Michigan, 49684, United States
Nemours Children's Clinic - Pensacola
RECRUITING

Pensacola, Florida, 32504, United States

Contact Email: •••••@•••••
Nemours Children's Clinic-Jacksonville
RECRUITING

Jacksonville, Florida, 32207, United States
Nemours Children's Hospital
RECRUITING

Orlando, Florida, 32827, United States
Primary Children's Hospital
RECRUITING

Salt Lake City, Utah, 84113, United States
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
RECRUITING

Toledo, Ohio, 43606, United States

Contact Email: •••••@•••••
Renown Regional Medical Center
RECRUITING

Reno, Nevada, 89502, United States
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
RECRUITING

Denver, Colorado, 80218, United States

Contact Email: •••••@•••••
Saint Christopher's Hospital for Children
RECRUITING

Philadelphia, Pennsylvania, 19134, United States
Saint Mary's Medical Center
RECRUITING

West Palm Beach, Florida, 33407, United States
Sinai Hospital of Baltimore
RECRUITING

Baltimore, Maryland, 21215, United States
The Children's Hospital at TriStar Centennial
RECRUITING

Nashville, Tennessee, 37203, United States
Trinity Health Grand Rapids Hospital
SUSPENDED

Grand Rapids, Michigan, 49503, United States
Trinity Health Muskegon Hospital
SUSPENDED

Muskegon, Michigan, 49444, United States
UMass Memorial Medical Center - University Campus
RECRUITING

Worcester, Massachusetts, 01655, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
University of Kentucky/Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Michigan Health - West
RECRUITING

Wyoming, Michigan, 49519, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States
University of Rochester
RECRUITING

Rochester, New York, 14642, United States
University of Texas Health Science Center at San Antonio
RECRUITING

San Antonio, Texas, 78229, United States

Contact Email: •••••@•••••
University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact Email: •••••@•••••
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITING

Madison, Wisconsin, 53718, United States

Contact Email: •••••@•••••
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States

Contact Email: •••••@•••••
Valley Children's Hospital
RECRUITING

Madera, California, 93636, United States

Contact Email: •••••@•••••
Wesley Medical Center
RECRUITING

Wichita, Kansas, 67214, United States

Contact Email: •••••@•••••
West Michigan Cancer Center
RECRUITING

Kalamazoo, Michigan, 49007, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.