New drug combo aims to shrink HER2-Positive tumors

NCT ID NCT06126276

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 22 times

Summary

This study tests whether adding palbociclib to neratinib works better than neratinib alone for people with HER2-positive solid tumors (excluding breast cancer). Both drugs block signals that help cancer cells grow. The trial enrolls 70 adults with advanced or recurrent gynecologic or other solid tumors. Participants are randomly assigned to one of the two treatment groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: neratinib and palbociclib
What this could lead to: If successful, this could provide a new treatment option for people with HER2-positive solid tumors that are not breast cancer.
What could go wrong: This is a Phase 2 trial with only 70 participants, so results may not apply to everyone. The combination may cause side effects like diarrhea or low blood cell counts.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer female reproductive organ cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MALIGNANT FEMALE REPRODUCTIVE SYSTEM NEOPLASM MALIGNANT SOLID NEOPLASM RECURRENT MALIGNANT FEMALE REPRODUCTIVE SYSTEM NEOPLASM RECURRENT MALIGNANT SOLID NEOPLASM

Contacts and locations

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Locations

Alaska Women's Cancer Care
RECRUITING

Anchorage, Alaska, 99508, United States
Annie Penn Memorial Hospital
RECRUITING

Reidsville, North Carolina, 27320, United States
Asplundh Cancer Pavilion
RECRUITING

Willow Grove, Pennsylvania, 19090, United States

Contact Email: •••••@•••••
Atrium Medical Center-Middletown Regional Hospital
RECRUITING

Franklin, Ohio, 45005-1066, United States

Contact Email: •••••@•••••
Ballad Health Cancer Care - Bristol
RECRUITING

Bristol, Virginia, 24201, United States
Ballad Health Cancer Care - Kingsport
RECRUITING

Kingsport, Tennessee, 37660, United States
Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

Contact Email: •••••@•••••
Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

Contact Email: •••••@•••••
Bristol Regional Medical Center
RECRUITING

Bristol, Tennessee, 37620, United States
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States
Cancer Center of Western Wisconsin
RECRUITING

New Richmond, Wisconsin, 54017, United States
Cancer Hematology Centers - Flint
RECRUITING

Flint, Michigan, 48503, United States
Carilion Roanoke Memorial Hospital
RECRUITING

Roanoke, Virginia, 24033, United States
Carle BroMenn Medical Center
RECRUITING

Normal, Illinois, 61761, United States

Contact Email: •••••@•••••
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Cancer Institute Normal
RECRUITING

Normal, Illinois, 61761, United States

Contact Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States

Contact Email: •••••@•••••
Centro Comprensivo de Cancer de UPR
RECRUITING

San Juan, 00927, Puerto Rico
Columbus Oncology and Hematology Associates
RECRUITING

Dublin, Ohio, 43016, United States
Columbus Oncology and Hematology Associates Inc
RECRUITING

Columbus, Ohio, 43214, United States
CommonSpirit Saint Joseph Medical Center - East Lexington
RECRUITING

Lexington, Kentucky, 40509, United States

Contact Email: •••••@•••••
Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

Contact Email: •••••@•••••
Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

Contact Email: •••••@•••••
Community Medical Center
RECRUITING

Toms River, New Jersey, 08755, United States
Cone Health Cancer Center
RECRUITING

Greensboro, North Carolina, 27403, United States
Cone Health Cancer Center at Alamance Regional
RECRUITING

Burlington, North Carolina, 27215, United States
Cone Health Cancer Center at Drawbridge Parkway
RECRUITING

Greensboro, North Carolina, 27410, United States
Cone Health MedCenter Asheboro
RECRUITING

Asheboro, North Carolina, 27205, United States
Corewell Health Beaumont Troy Hospital
SUSPENDED

Troy, Michigan, 48085, United States
Corewell Health Dearborn Hospital
SUSPENDED

Dearborn, Michigan, 48124, United States
Corewell Health Farmington Hills Hospital
SUSPENDED

Farmington Hills, Michigan, 48336, United States
Corewell Health William Beaumont University Hospital
SUSPENDED

Royal Oak, Michigan, 48073, United States
Crossroads Cancer Center
RECRUITING

Effingham, Illinois, 62401, United States
Dayton Physician LLC - Englewood
SUSPENDED

Dayton, Ohio, 45415, United States
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States
Delaware Health Center-Grady Cancer Center
RECRUITING

Delaware, Ohio, 43015, United States
Doctors Hospital
RECRUITING

Columbus, Ohio, 43228, United States
Dublin Methodist Hospital
RECRUITING

Dublin, Ohio, 43016, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Duke Women's Cancer Care Raleigh
RECRUITING

Raleigh, North Carolina, 27607, United States
Duluth Clinic Ashland
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact Email: •••••@•••••
Essentia Health - Deer River Clinic
RECRUITING

Deer River, Minnesota, 56636, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Essentia Health Hibbing Clinic
RECRUITING

Hibbing, Minnesota, 55746, United States
Essentia Health Sandstone
RECRUITING

Sandstone, Minnesota, 55072, United States

Contact Email: •••••@•••••
Essentia Health Virginia Clinic
RECRUITING

Virginia, Minnesota, 55792, United States

Contact Email: •••••@•••••
Genesee Hematology Oncology PC
SUSPENDED

Flint, Michigan, 48503, United States
Genesys Hurley Cancer Institute
RECRUITING

Flint, Michigan, 48503, United States
Grady Memorial Hospital
RECRUITING

Delaware, Ohio, 43015, United States
Grant Medical Center
RECRUITING

Columbus, Ohio, 43215, United States
Gundersen Lutheran Medical Center
RECRUITING

La Crosse, Wisconsin, 54601, United States

Contact Email: •••••@•••••
Harold Alfond Center for Cancer Care
RECRUITING

Augusta, Maine, 04330, United States
Hurley Medical Center
RECRUITING

Flint, Michigan, 48503, United States
Inova Fairfax Hospital
RECRUITING

Falls Church, Virginia, 22042, United States
Inova Schar Cancer Institute
RECRUITING

Fairfax, Virginia, 22031, United States
Jersey City Medical Center
RECRUITING

Jersey City, New Jersey, 07302, United States
John H Stroger Jr Hospital of Cook County
SUSPENDED

Chicago, Illinois, 60612, United States
Kettering Medical Center
SUSPENDED

Kettering, Ohio, 45429, United States
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

Contact Email: •••••@•••••
Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

Contact Email: •••••@•••••
Lafayette Family Cancer Center-EMMC
RECRUITING

Brewer, Maine, 04412, United States
Logan Health Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

Contact Email: •••••@•••••
MaineHealth Maine Medical Center- Scarborough
RECRUITING

Scarborough, Maine, 04074, United States

Contact Email: •••••@•••••
Marshfield Medical Center - Minocqua
RECRUITING

Minocqua, Wisconsin, 54548, United States

Contact Email: •••••@•••••
Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

Contact Email: •••••@•••••
Marshfield Medical Center-EC Cancer Center
RECRUITING

Eau Claire, Wisconsin, 54701, United States

Contact Email: •••••@•••••
Marshfield Medical Center-Marshfield
RECRUITING

Marshfield, Wisconsin, 54449, United States

Contact Email: •••••@•••••
Marshfield Medical Center-Rice Lake
RECRUITING

Rice Lake, Wisconsin, 54868, United States

Contact Email: •••••@•••••
Marshfield Medical Center-River Region at Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54482, United States

Contact Email: •••••@•••••
Mayo Clinic in Rochester
SUSPENDED

Rochester, Minnesota, 55905, United States
Mercyhealth Cancer Institute - Rockford
RECRUITING

Rockford, Illinois, 61114, United States

Contact Email: •••••@•••••
Miami Valley Cancer Care and Infusion
RECRUITING

Greenville, Ohio, 45331, United States
Miami Valley Hospital
RECRUITING

Dayton, Ohio, 45409, United States

Contact Email: •••••@•••••
Miami Valley Hospital North
RECRUITING

Dayton, Ohio, 45415, United States

Contact Email: •••••@•••••
Miami Valley Hospital South
RECRUITING

Centerville, Ohio, 45459, United States

Contact Email: •••••@•••••
Minnesota Oncology - Edina
RECRUITING

Edina, Minnesota, 55435, United States
Monmouth Medical Center
RECRUITING

Long Branch, New Jersey, 07740, United States
Monmouth Medical Center Southern Campus
RECRUITING

Lakewood, New Jersey, 08701, United States
National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States
NorthShore University HealthSystem-Evanston Hospital
RECRUITING

Evanston, Illinois, 60201, United States
NorthShore University HealthSystem-Glenbrook Hospital
RECRUITING

Glenview, Illinois, 60026, United States
NorthShore University HealthSystem-Highland Park Hospital
RECRUITING

Highland Park, Illinois, 60035, United States
OSF Saint Francis Hospital and Medical Group
RECRUITING

Escanaba, Michigan, 49829, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
OhioHealth Mansfield Hospital
RECRUITING

Mansfield, Ohio, 44903, United States
OhioHealth Marion General Hospital
RECRUITING

Marion, Ohio, 43302, United States
OhioHealth O'Bleness Hospital
RECRUITING

Athens, Ohio, 45701, United States
OhioHealth Pickerington Methodist Hospital
RECRUITING

Pickerington, Ohio, 43147, United States
OhioHealth Westerville Medical Campus/Westerville Cancer Center
RECRUITING

Westerville, Ohio, 43082, United States
OptumCare Cancer Care at Charleston
RECRUITING

Las Vegas, Nevada, 89102, United States

Contact Email: •••••@•••••
OptumCare Cancer Care at Fort Apache
RECRUITING

Las Vegas, Nevada, 89183, United States

Contact Email: •••••@•••••
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States

Contact Email: •••••@•••••
Premier Blood and Cancer Center
RECRUITING

Dayton, Ohio, 45409, United States
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact Email: •••••@•••••
Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

Contact Email: •••••@•••••
Regional Cancer Center at Johnson City Medical Center
RECRUITING

Johnson City, Tennessee, 37604, United States
Riverside Methodist Hospital
RECRUITING

Columbus, Ohio, 43214, United States
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States
SIH Cancer Institute
RECRUITING

Carterville, Illinois, 62918, United States

Contact Email: •••••@•••••
Saint Alphonsus Cancer Care Center-Boise
RECRUITING

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell
RECRUITING

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa
RECRUITING

Nampa, Idaho, 83687, United States

Contact Email: •••••@•••••
Saint Alphonsus Cancer Care Center-Ontario
RECRUITING

Ontario, Oregon, 97914, United States

Contact Email: •••••@•••••
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States
Saint John's Hospital - Healtheast
RECRUITING

Maplewood, Minnesota, 55109, United States
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83687, United States
Saint Vincent Hospital Cancer Center Green Bay
RECRUITING

Green Bay, Wisconsin, 54301, United States
Saint Vincent Hospital Cancer Center at Oconto Falls
RECRUITING

Oconto Falls, Wisconsin, 54154, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
RECRUITING

Green Bay, Wisconsin, 54303, United States
Saint Vincent Hospital Cancer Center at Sheboygan
RECRUITING

Sheboygan, Wisconsin, 53081, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
RECRUITING

Sturgeon Bay, Wisconsin, 54235-1495, United States
Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

Contact Email: •••••@•••••
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Email: •••••@•••••
Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

Contact Email: •••••@•••••
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
Scott and White Memorial Hospital
RECRUITING

Temple, Texas, 76508, United States
Southeastern Medical Oncology Center-Clinton
RECRUITING

Clinton, North Carolina, 28328, United States
Southeastern Medical Oncology Center-Goldsboro
RECRUITING

Goldsboro, North Carolina, 27534, United States
Southeastern Medical Oncology Center-Jacksonville
RECRUITING

Jacksonville, North Carolina, 28546, United States
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital
RECRUITING

Springfield, Illinois, 62781, United States
State University of New York Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States
Swedish Cancer Institute-Edmonds
RECRUITING

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah
RECRUITING

Issaquah, Washington, 98029, United States
Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States
The Angeles Clinic and Research Institute - West Los Angeles Office
RECRUITING

Los Angeles, California, 90025, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Email: •••••@•••••
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
RECRUITING

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States
UC San Diego Health System - Encinitas
RECRUITING

Encinitas, California, 92024, United States
UC San Diego Medical Center - Hillcrest
RECRUITING

San Diego, California, 92103, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States

Contact Email: •••••@•••••
UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING

Waukee, Iowa, 50263, United States
UM Sylvester Comprehensive Cancer Center at Aventura
RECRUITING

Aventura, Florida, 33180, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITING

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Coral Springs
RECRUITING

Coral Springs, Florida, 33065, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Kendall
RECRUITING

Miami, Florida, 33176, United States
UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITING

Plantation, Florida, 33324, United States
UPMC Altoona
RECRUITING

Altoona, Pennsylvania, 16601, United States
UPMC Cancer Centers - Arnold Palmer Pavilion
RECRUITING

Greensburg, Pennsylvania, 15601, United States
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UPMC Hillman Cancer Center - Monroeville
RECRUITING

Monroeville, Pennsylvania, 15146, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center Erie
RECRUITING

Erie, Pennsylvania, 16505, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
RECRUITING

Mechanicsburg, Pennsylvania, 17050, United States
UPMC Western Maryland
RECRUITING

Cumberland, Maryland, 21502, United States
UPMC-Magee Womens Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
UPMC-Passavant Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15237, United States
UT MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
University of Alabama at Birmingham Cancer Center
RECRUITING

Birmingham, Alabama, 35233, United States
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
University of Kentucky/Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Maryland/Greenebaum Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
RECRUITING

North Miami, Florida, 33181, United States
University of Michigan Health - Sparrow Lansing
RECRUITING

Lansing, Michigan, 48912, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of South Alabama Mitchell Cancer Institute
RECRUITING

Mobile, Alabama, 36688, United States
University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact Email: •••••@•••••
Upper Valley Medical Center
RECRUITING

Troy, Ohio, 45373, United States

Contact Email: •••••@•••••
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Vanderbilt University/Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States
Walter Reed National Military Medical Center
RECRUITING

Bethesda, Maryland, 20889-5600, United States
Wellmont Holston Valley Hospital and Medical Center
RECRUITING

Kingsport, Tennessee, 37660, United States
West Virginia University Healthcare
RECRUITING

Morgantown, West Virginia, 26506, United States

Contact Email: •••••@•••••
Women and Infants Hospital
RECRUITING

Providence, Rhode Island, 02905, United States
Woodland Cancer Care Center
RECRUITING

Michigan City, Indiana, 46360, United States

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