MALIGNANT SOLID NEOPLASM

This study tested a new combination treatment for people with advanced non-small cell lung cancer that had spread. It combined the immunotherapy drug pembrolizumab with two types of radiation therapy to see if the pair could shrink tumors better than either alone. The trial enrol…

This study tested a new antibiotic combination (imipenem-relebactam) against standard antibiotics for treating fever caused by low white blood cells in 100 adults with cancer. The goal was to see if the new drug works as well or better at controlling infections. Results help doct…

This early-phase trial tested a new combination of drugs for people with extensive-stage small cell lung cancer that had not been treated before. The study added entinostat to standard treatments (atezolizumab, carboplatin, and etoposide) to see the best dose and possible side ef…

This study tested the drug pegloticase in 10 cancer patients with high uric acid levels caused by tumor lysis syndrome, a complication where dying cancer cells release substances that can damage the kidneys. The goal was to see if pegloticase could quickly lower uric acid and pro…

This study tested whether small, adhesive sensors placed on the skin can detect early signs of lymphedema, a painful arm swelling that can happen after cancer treatment. Researchers compared readings from 76 people with and without lymphedema to see if the sensors could tell the …

This study tested whether a rose geranium and sesame oil nasal spray can improve nose symptoms like dryness, discomfort, bleeding, or scabbing in cancer patients receiving chemotherapy. About 106 adults with these symptoms took part. The spray was compared to a plain saline spray…

This study tested whether using electronic health records to track and manage common cancer symptoms—such as pain, fatigue, sleep problems, anxiety, and depression—can improve quality of life and reduce hospital visits. Over 50,000 cancer patients took part. The goal was to see i…

This study tested a program called Mates in Motion, designed to help blood cancer patients and their caregiving partners become more physically active together. The program taught communication and behavior-change skills to support each other in staying active. Researchers wanted…

This study tested whether doing simple positive activities, like helping with household chores or writing a thank-you letter, can improve quality of life for cancer patients from collectivist cultures (e.g., Latino, Asian American, African American). 75 patients and their caregiv…

This study tested whether young cancer survivors (ages 15-39) can learn to do acupressure on themselves to reduce fatigue. 42 participants who had finished cancer treatment at least 3 months ago and still felt tired were taught relaxing acupressure. The goal was to see if it's pr…

This study tested a pain management program for 51 cancer survivors living in rural areas or who are Hispanic. The goal was to see if the program was easy to use and helpful for controlling cancer-related pain. Researchers measured how often participants used the program and how …

This study tested a virtual program that combines mindfulness exercises with weight management for obese cancer survivors. The goal was to see if it could improve mood, reduce stress, and help with weight loss. Nineteen adults who had stage I-III cancer and a BMI of 30 or higher …

This pilot study tested whether acupressure, a non-invasive technique using finger pressure on specific body points, can help reduce anxiety in patients receiving chemotherapy. Thirty adults undergoing chemo at Mayo Clinic who reported at least mild anxiety took part. The study f…

This study looked at whether increasing physical activity through a 12-week virtual exercise program could improve physical function and quality of life in cancer survivors who are over 60 or live in rural areas. About 100 participants completed the program, which focused on endu…

This study tested a cream made from cannabidiol (CBD) to see if it could reduce nerve pain, numbness, or tingling in the hands and feet caused by chemotherapy. Forty adults with cancer who had moderate to severe nerve symptoms took part. Half used the CBD cream and half used a pl…

This study tested a program called GUIDE, where a trained navigator helps cancer patients overcome social and financial barriers to join clinical trials. About 100 adults with cancer who had at least one need (like food, housing, or money worries) took part. The goal was to see i…

This study tested if wearable devices and smartphone apps can better track cancer patients' vital signs and symptoms than standard in-person checks. About 100 adults with various cancers used a device and app at home. The goal was to see if remote monitoring can detect problems l…

This study tested a program called FinFit to help adolescent and young adult cancer survivors deal with money problems caused by their illness. Researchers interviewed 16 people from community cancer clinics to understand how to best deliver financial support. The goal was to cre…

This study looked at tumor tissue and blood samples from 141 adults with glioblastoma or other solid tumors. The goal was to measure cell counts and viability to help scientists develop better treatments in the future. Participants were already scheduled for surgery, and the stud…

This study tested a program designed to help adolescent and young adult cancer survivors (ages 15-39) find and use healthcare resources after treatment. The goal was to improve their health knowledge, self-care skills, and support, and to reduce cancer-related distress. 549 survi…

This study looked at how chemotherapy affects symptoms, daily function, and falls in 200 cancer patients aged 40-85. Researchers used questionnaires and wearable devices like instrumented socks and activity trackers to find simple ways to predict when patients are at higher risk …

This study looked at whether adding a type of antibiotic called aminoglycosides helps cancer patients with sepsis and low blood pressure recover faster. Researchers compared patients who got these extra antibiotics to those who did not. The main goal was to see how quickly blood …

This study tested whether 3D surface images can be used instead of standard CT scans to plan electron radiation therapy for adults with certain cancers. Researchers used plastic models (not real patients) to compare the accuracy of 3D scans and CT scans. If successful, this appro…

This study tested a training program for community healthcare providers to improve their knowledge and skills in caring for cancer survivors. Twenty-eight providers from five Ohio hospitals participated. The program aimed to help doctors better understand survivors' long-term hea…