MALIGNANT SOLID NEOPLASM

This study is testing whether a combination of two oral drugs, talazoparib and temozolomide, can shrink advanced rare cancers that have spread and for which standard treatments have stopped working. The trial aims to see if this drug pair can stop tumor growth by damaging cancer …

This study is testing a drug called tipifarnib in children and young adults whose advanced cancers have a specific genetic change in a gene called HRAS. The goal is to see if the drug can shrink tumors and control the disease. Participants take the drug as a pill or through a fee…

This study is testing different ways to help childhood and young adult cancer survivors become more physically active and improve their diets. Researchers are comparing several approaches including telehealth sessions with clinicians, personalized goal-setting with social media s…

This study compares two smartphone apps designed to help cancer patients quit smoking. Researchers want to see if the new Quit2Heal app works better than the existing QuitGuide app at helping patients stay smoke-free for a full year. The trial involves 427 cancer patients who cur…

This early-stage study is testing a new oral drug called IPdR (ropidoxuridine) in combination with standard whole-brain radiation therapy. The goal is to see if the drug makes cancer cells in the brain more sensitive to radiation, potentially improving treatment for patients whos…

This study is testing whether the drug erdafitinib can help control advanced solid tumors that have specific genetic changes called FGFR mutations or fusions. The drug works by blocking a faulty protein that tells cancer cells to grow. The trial enrolled 35 adults whose cancer ha…

This study compares two drugs, infliximab and vedolizumab, to treat severe colon inflammation and diarrhea caused by cancer immunotherapy drugs. The trial involves 47 patients with melanoma, lung cancer, or urinary cancers who developed these side effects. Researchers aim to find…

This study is testing a new three-drug combination to see if it works better than the current two-drug standard for treating advanced melanoma with a specific BRAF gene mutation. The trial aims to find the safest dose and see if adding a third drug (navitoclax) helps shrink tumor…

This study is testing whether combining a targeted form of radiation therapy with an immunotherapy drug (pembrolizumab) is safe and more effective than the drug alone for patients with advanced non-small cell lung cancer that has spread. The goal is to see if the radiation helps …

This large national trial is testing whether a combination of two immunotherapy drugs (nivolumab and ipilimumab) can help control over 50 different types of rare cancers that have few or no standard treatment options. It enrolled over 800 adults whose rare cancers had progressed …

This early-stage study is testing the safety and best doses of a combination of cancer drugs for people with advanced cancers of the urinary system (like bladder and kidney cancer) that have spread. The trial combines a pill (cabozantinib) that aims to block tumor growth with one…

This early-stage study is testing the safety and best dose of a chemotherapy drug called eribulin when given with radiation therapy before surgery. It involves 15 patients with a rare abdominal cancer called retroperitoneal liposarcoma. The goal is to see if this combined approac…

This study is testing a personalized cell therapy called LN-145 for patients with advanced cancers that have stopped responding to standard treatments. Doctors collect a patient's own immune cells from their tumor, grow large numbers of them in a lab, and then infuse them back in…

This study is testing a treatment for a viral infection called CMV that can be dangerous for people who have had a stem cell transplant. It uses special white blood cells from a donor who has fought off CMV before. The goal is to see if these 'borrowed' immune cells can help clea…

This study is testing whether taking two oral drugs together—palbociclib and binimetinib—is better than taking one of them alone for controlling advanced cancers that have specific genetic changes called RAS mutations. It focuses on certain hard-to-treat cancers like low-grade ov…

This study is testing whether the drug copanlisib can help control advanced cancers that have lost a specific protein called PTEN. The trial includes 22 patients with various solid tumors that have stopped responding to standard treatments. Researchers are giving the drug through…

This study is testing if a drug called pegloticase can quickly lower dangerously high uric acid levels in cancer patients. High uric acid is a side effect of some cancer treatments and can damage the kidneys. The goal is to see if one or two doses of pegloticase can protect kidne…

This study is testing a drug called ensartinib in children and young adults whose advanced cancers have specific genetic changes (ALK or ROS1). The goal is to see if the drug can shrink tumors or stop them from growing in patients whose cancer has come back or hasn't responded to…

This study is testing the safety and effectiveness of avelumab, an immunotherapy drug, when given in combination with other immune-boosting drugs and sometimes radiation. It is for patients with advanced solid tumors that have spread and who have run out of standard treatment opt…

This early-stage study is testing the safety and best dose of a three-drug combination (entinostat, nivolumab, and ipilimumab) for people with advanced solid tumors that have spread and are hard to treat. The goal is to see if boosting the immune system with two drugs while using…

This small pilot study is testing whether a simple home exercise program, with or without a vitamin B3-like supplement, is a practical way to help adult survivors of childhood cancer who have prediabetes. The goal is to see if this approach can improve muscle health and how the b…

This study is testing a combination of two immunotherapy drugs, tiragolumab and atezolizumab, for children and adults with rare, aggressive cancers that have come back or stopped responding to standard treatments. These cancers are missing specific genes (SMARCB1 or SMARCA4). The…

This trial is testing whether a combination of two targeted drugs, trastuzumab and pertuzumab, can help control advanced cancers that have a specific genetic feature called HER2 amplification. The study is for patients whose cancers are not breast, stomach, or colorectal, as thes…

This study is testing whether two oral drugs, olaparib and ceralasertib (AZD6738), can help control advanced solid tumors that have a specific genetic change called an IDH mutation and have stopped responding to standard therapies. It is for adults with cancers like cholangiocarc…

This study is testing a combination of three immunotherapy drugs—tocilizumab, ipilimumab, and nivolumab—in patients with advanced melanoma, non-small cell lung cancer, or bladder cancer. The main goal is to see if adding tocilizumab can help manage the serious side effects someti…

This study is testing a new way to calculate the dose of the cancer drug vincristine for infants and very young children. The goal is to give them drug levels in their blood that are similar to older children, who use a standard dosing method, while trying to reduce severe side e…

This study is testing whether portable heart monitoring devices used at home can detect early heart problems in childhood cancer survivors as accurately as standard clinic tests. Researchers are comparing two portable systems against echocardiograms and MRI scans to see if home m…

This study is testing small, wearable sensors that stick to the skin to see if they can detect early signs of arm swelling (lymphedema) in cancer survivors. Researchers want to see if these sensors, which measure tiny changes in tissue, can tell the difference between a healthy a…

This study is testing whether a widely available probiotic supplement can prevent a serious and painful side effect of cancer immunotherapy. It involves 12 adults with solid tumors who are receiving immunotherapy, which can cause severe colon inflammation and diarrhea in nearly h…

This study is testing whether a daily broccoli seed and sprout extract can boost the body's natural ability to clear out cancer-causing chemicals that firefighters breathe in during their work. It involves 66 active, non-smoking firefighters who will take either the broccoli extr…

This study is testing a combination of treatments to help cancer patients who are having trouble sleeping. It combines counseling sessions with possible use of a stimulant, melatonin, and light therapy. The goal is to see if this package improves sleep quality, reduces fatigue, a…

This study is testing whether a yoga program can help cancer patients and their partners feel better during radiation treatment. It will enroll 600 couples where one person has lung, head and neck, or esophageal cancer. Researchers want to see if doing yoga together improves phys…

This study is testing whether the drug bupropion can help reduce severe, long-lasting fatigue in people who have finished their main cancer treatments. Researchers are comparing the drug against a placebo (a dummy pill) in over 400 cancer survivors. The goal is to see if this med…

This study is testing if a dietary supplement called PEA can relieve nerve pain, numbness, and tingling caused by chemotherapy in cancer survivors. About 88 participants who have had these symptoms for at least 3 months will take either PEA or a placebo pill for 8 weeks. Research…

This study is testing whether adding a special digital app and web platform can improve depression care for people undergoing cancer treatment. It compares this tech-enhanced approach to the usual collaborative care methods. The goal is to see if the technology helps patients and…

This study looks at whether a special light therapy can help reduce painful mouth sores and other oral problems in cancer patients receiving stem cell transplants. Researchers will observe 6 adult patients and their nurses to see how well the therapy works at controlling symptoms…

This study aims to find the best way to give intravenous pain medicine to hospitalized cancer patients. Researchers are comparing whether giving the drug hydromorphone quickly over 2 minutes or slowly over 15 minutes provides better pain relief while lowering the risk of patients…

This study is testing a mobile health program designed to help young people who have survived childhood cancer become more physically active. It compares a full program—which includes a Fitbit, personalized goal setting, and a social media support group—against just wearing a Fit…

This study is testing a new mobile phone app designed to help cancer patients during radiation therapy. The app provides education and guidance on managing treatment side effects and logistics. Researchers want to see if patients find the app easy to use and helpful. The study in…

This study is testing if a simple, home-based exercise program can better relieve the nerve pain, numbness, and tingling that often follows chemotherapy. About 133 cancer patients who have this side effect are being assigned to either follow a 6-week walking and resistance progra…

This study is testing whether smelling lavender or similar scents can help reduce pain and anxiety for cancer patients during bone marrow biopsy procedures. Researchers want to see if this simple, drug-free approach can make these uncomfortable tests easier to tolerate. The trial…

This study is testing if fast-acting opioid medications, normally used for pain, can help control the distressing shortness of breath cancer patients feel during physical activity. It will compare two opioids (fentanyl and morphine) against a placebo in 150 patients. The main goa…

This study aims to understand if Black and White cancer patients experience different side effects and treatment results when receiving immunotherapy drugs. Researchers will follow 2,100 patients already scheduled to receive these treatments in community cancer clinics. By collec…

This study aims to understand cancer screening awareness and barriers among incarcerated women. Researchers will survey 1,200 women at a Florida prison to learn about their knowledge, screening history, and challenges. The information will be used to create a digital education pr…

This study is testing a symptom questionnaire designed specifically for teenagers with cancer. Researchers are interviewing 13-17 year old cancer patients to see if the questionnaire accurately captures their experiences with pain, fatigue, and other symptoms. The goal is to crea…

This study is observing people who have cancer and also get COVID-19. Researchers are collecting blood samples and health information from nearly 1,900 participants over two years. The goal is to understand how having cancer changes the course of COVID-19, and how getting COVID-1…

This study aims to understand the worries parents have about giving opioid pain medication to their children with cancer. Researchers are surveying 110 parents to learn why some might hesitate to use these strong pain relievers, even when their child is hurting. The information w…

This study is testing whether people find it acceptable to use a full-body MRI scan and a special blood test (liquid biopsy) to try to detect cancer early. It involves 100 adults with a strong family history of cancer. The main goal is to see if people are comfortable with this a…

This early study is testing a new type of PET-CT scan that uses a special tracer to measure oxygen levels inside solid tumors. The goal is to see if this scan is reliable and safe, and to find the best timing for it. Doctors hope that mapping a tumor's oxygen can help them plan m…

This early-stage study is testing a new imaging agent called 68Ga-FAPI-46 to see where it goes in the body of patients with many different types of cancer. The goal is to understand if this tracer can help doctors better see and understand tumors by highlighting specific cells ar…

This study aims to understand the financial stress cancer patients experience and what personal and social factors help them cope. Researchers are surveying 625 recently diagnosed patients to learn how their confidence, support networks, and financial knowledge relate to this str…

This study aims to understand how the COVID-19 pandemic affected the well-being and quality of life of cancer patients and survivors. Researchers are surveying over 13,000 patients about their pandemic experiences, including health impacts, financial stress, and emotional challen…

This study aims to understand cancer patients' preferences and experiences when using marijuana products (THC or CBD) alongside prescription opioids for pain. Researchers are surveying 200 patients with cancer-related pain in Texas and Arizona to learn which combination they find…

This study aims to understand how patients with cancer or COVID-19 perceive their doctor's empathy. Researchers are comparing two visit types: in-person where the doctor wears full protective equipment (PPE) versus a video call where the doctor does not. The goal is to learn whic…

This study aims to understand if immunotherapy treatments for cancer affect a patient's balance and hearing. Researchers will follow 50 adults who are starting specific immunotherapies as part of their standard cancer care. They will compare balance and hearing tests done before …

This study is testing a new type of PET-CT scanner called the RefleXion system. Researchers want to see if its images are as good as standard PET-CT scans at finding cancer spots in patients with various tumors. The goal is to learn if this new system could one day allow doctors …

This study aims to learn how the COVID-19 pandemic affected the quality of life of cancer patients who also have nerve pain (neuropathy). Researchers are surveying 274 patients who were in previous studies to see if their pain, anxiety, and daily life were impacted. They also wan…

This study aims to understand how well the COVID-19 vaccine works in children, teens, and young adults who have cancer. Researchers are observing about 550 participants who are getting vaccinated during or after their cancer treatment. They will check blood samples over two years…

This study aims to understand why certain cancers develop at younger ages in people from different racial and ethnic backgrounds. Researchers will collect tumor tissue and blood samples from 2,400 patients during their regular cancer surgeries. By analyzing these samples, they ho…

This study aims to understand why minority and underserved cancer patients often do not join clinical trials. Researchers are surveying patients about their knowledge and attitudes, then testing a personalized educational platform designed to provide clear information and support…

This study is testing whether providing training and support to cancer clinic staff helps them deliver a special health check-up for older adults starting new cancer treatments. The check-up looks at a patient's overall physical health, support network, and daily life impact, not…

This study is testing a web-based education tool called HOPE-Genomics to see if it helps cancer patients better understand their personal genetic test results and general cancer genomics. Researchers are comparing the tool's effectiveness against standard education methods in abo…

This study aims to understand if low testosterone levels might increase a person's risk of developing dementia, depression, or anxiety. Researchers will analyze existing genetic and health data from large public biobanks, not recruit new participants. The goal is to gather knowle…

This study aims to understand how the COVID-19 pandemic impacted the well-being and quality of life of cancer patients, regardless of whether they got COVID-19. Over 1,200 former participants from prior behavioral studies completed a 35-45 minute online survey about their pandemi…

This study aims to understand what cancer patients and their radiation doctors think about using video calls for appointments. Researchers are surveying 200 people who have already had a telemedicine visit for cancer care. The goal is to learn about satisfaction, identify challen…

This study aimed to gather information to help design future 'hospital at home' programs for cancer patients with fever and low white blood cell counts. Researchers planned to review medical records to see how often these patients had serious complications and what treatments the…

This study aims to find the best way to spot malnutrition in older adults with cancer. Researchers will test four different screening methods to see which one best predicts a patient's risk of dying or needing unplanned hospital care over the next year. The goal is to improve how…

This study is testing whether regular virtual team meetings can help cancer imaging specialists feel less burned out and more connected to their colleagues. Researchers want to see if this telementoring program is practical and if it improves doctors' well-being and job satisfact…