MALIGNANT SOLID NEOPLASM

This study tests two immunotherapy drugs, tiragolumab and atezolizumab, in children and adults whose rare cancers (like atypical teratoid/rhabdoid tumors or epithelioid sarcoma) have returned or not responded to treatment. These cancers lack certain genes, making them hard to tre…

This early-phase trial tests the safety and best dose of a combination of two or three drugs (cabozantinib, nivolumab, and possibly ipilimumab) in people with advanced genitourinary cancers that have spread. About 152 adults with these cancers will participate. The goal is to fin…

This study tests a combination of three drugs (dabrafenib, trametinib, and navitoclax) in people with BRAF-mutant melanoma that has spread or cannot be removed by surgery, and in other solid tumors. The goal is to find the best dose and see how well the drugs shrink tumors. About…

This study tests a combination of two targeted drugs, palbociclib and binimetinib, in people with cancers that have RAS mutations (like certain ovarian and pancreatic cancers). The goal is to see if the combo can slow tumor growth better than one drug alone. About 199 adults will…

This study tests whether adding tocilizumab to two standard immunotherapy drugs (ipilimumab and nivolumab) can reduce severe side effects while still fighting cancer. About 35 adults with advanced melanoma, non-small cell lung cancer, or bladder cancer will receive the combinatio…

This study tests whether combining two targeted drugs, trastuzumab and pertuzumab, can shrink or control cancers that have too much of a protein called HER2. It includes adults with solid tumors that are not breast, stomach, or colorectal cancers. The goal is to see if this drug …

This study was designed to test if itacitinib can help cancer patients whose immune system overreacts to immunotherapy drugs, causing side effects that steroids can't control. The drug works by calming the immune response. However, the trial was withdrawn before enrolling any par…

This study tests whether specially trained white blood cells from donors can treat a stubborn CMV infection in people who have had a stem cell transplant. About 49 participants will receive these cells to see if the infection clears. The goal is to control the virus when standard…

This study tests whether a combination of two drugs, talazoparib and temozolomide, can shrink advanced rare cancers or stop them from growing. The trial includes 14 adults with rare solid tumors that have not responded to standard treatments. Talazoparib blocks a protein that hel…

This study tests the safety and effectiveness of combining the immunotherapy drug avelumab with other treatments (utomilumab, anti-OX40 antibody, and radiation) in people with advanced cancers that have spread. About 173 adults whose cancer has not responded to standard therapies…

This study compares two medications, infliximab and vedolizumab, for treating colitis (colon inflammation) caused by immune checkpoint inhibitor therapy in cancer patients. About 47 adults with genitourinary cancer, melanoma, or non-small cell lung cancer will receive one of thes…

This study tests a drug called tipifarnib in children and young adults (ages 1 to 21) whose cancer has returned or spread and has a specific change in the HRAS gene. The goal is to see if the drug can shrink tumors or stop them from growing. About 5 participants received the drug…

This study tests a drug called copanlisib in 22 adults with various cancers that have lost a protein called PTEN. The drug works by blocking enzymes that help cancer cells grow. The main goal is to see if tumors shrink or stop growing, but this is not a cure—patients may need ong…

This study tests whether a smartphone app called Quit2Heal can help cancer patients quit smoking better than another app called QuitGuide. About 427 adults with cancer who smoke will use one of the two apps for support. The main goal is to see how many people can stay smoke-free …

This early-phase study tests the safety and best doses of three drugs—entinostat, nivolumab, and ipilimumab—given together to people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if this combination can help the immune system figh…

This study tested the drug ensartinib in children and young adults (ages 1 to 21) whose advanced solid tumors, lymphoma, or related cancers had come back or stopped responding to treatment and had specific gene changes (ALK or ROS1). The goal was to see if the drug could shrink o…

This phase 2 trial tests a combination of two immunotherapy drugs (nivolumab and ipilimumab) in over 800 people with more than 50 types of rare cancers. The goal is to see if this treatment can shrink tumors by helping the immune system attack cancer cells. The study is for patie…

This phase 2 trial tests a personalized cell therapy called LN-145 for people with certain advanced cancers (like ovarian, breast, thyroid, or bone cancers) that have not responded to treatment or have returned. The therapy uses a patient's own immune cells, taken from their tumo…

This study tests whether a daily supplement made from broccoli seeds and sprouts can help firefighters remove harmful chemicals from their bodies. Firefighters are often exposed to cancer-causing substances like benzene from smoke and fires. The trial involves 72 firefighters who…

This study tested two drugs, olaparib and ceralasertib, in 24 people with advanced solid tumors that have an IDH mutation, including a type of bile duct cancer. The goal was to see if the combination could shrink or stop tumor growth. Unfortunately, no patients had their tumors s…

This study tests a drug called erdafitinib in 35 adults whose cancers have certain FGFR gene changes. The drug blocks a faulty protein that helps cancer grow, potentially shrinking tumors or slowing the disease. It is a phase 2 trial for people with advanced solid tumors that hav…

This early-stage trial tests the safety and best dose of the chemotherapy drug eribulin given together with radiation before surgery for a rare cancer called retroperitoneal liposarcoma. About 15 adults with this tumor will receive the combination to see how well they tolerate it…

This early-phase study tests a special PET-CT scan that uses a tracer called FAZA to measure oxygen levels inside solid tumors. About 25 adults with breast, pancreas, or colorectal cancer will be scanned twice to see if the results are consistent. The goal is to help doctors plan…

This study checks if portable, easy-to-use devices can detect early signs of heart damage in childhood cancer survivors. About 149 people who finished cancer treatment will use these devices at home and in the clinic. The goal is to see if these tools are as accurate as standard …

This study tests whether taking an over-the-counter probiotic (VSL#3) can prevent colitis (colon inflammation and diarrhea) in cancer patients receiving immunotherapy. About 12 adults with solid tumors who are starting or have just started immunotherapy will take the probiotic da…

This early-phase study tests an oral drug called ropidoxuridine (IPdR) combined with whole-brain radiation in people whose cancer has spread to the brain. The goal is to find the safest dose and see if the drug makes radiation work better by sensitizing tumor cells. Only 11 parti…

This phase 3 trial tests whether bupropion, a drug used for depression and smoking cessation, can reduce fatigue in cancer survivors. About 422 adults who have completed cancer treatment and still suffer from moderate to severe fatigue will take bupropion or a placebo. The study …

This study looks at whether breathing in lavender aromatherapy oil can help cancer patients feel less pain and anxiety during a bone marrow biopsy. About 45 adults with cancer who are nervous about the procedure will try the oil or a placebo. The goal is to find a simple, drug-fr…

This study looks at whether exercise can reduce symptoms of chemotherapy-induced peripheral neuropathy (CIPN), such as pain, numbness, and tingling in the hands and feet. About 133 cancer patients who have nerve damage from chemo will either do an exercise program or receive usua…

This study looks at how fast or slow a painkiller (hydromorphone) is given through an IV affects cancer patients' pain relief and their risk of misusing the drug. About 84 hospitalized cancer patients with moderate to severe pain will receive the same medicine at two different sp…

This study tests whether a brief behavioral therapy program (BBT-CI) works better than healthy eating education (HEAL) for reducing insomnia in cancer patients. About 400 adults with stage I-IV cancer who are currently receiving treatment and have sleep problems will take part. T…

This study looks at whether a yoga program can help cancer patients and their partners improve physical function, quality of life, and reduce symptoms like fatigue and distress during radiation therapy. About 600 patients with lung, head and neck, or esophageal cancer, along with…

This study tests whether a natural supplement called PEA can relieve nerve pain, numbness, and tingling caused by chemotherapy in cancer patients. About 88 adults who have had these symptoms for at least 3 months will take PEA or a placebo for 8 weeks. The goal is to see if PEA i…

This study looks at whether a special light treatment (photobiomodulation) can help reduce mouth sores, pain, taste changes, and dry mouth in patients receiving a stem cell transplant. Six adult patients with blood or solid tumor cancers are being studied. The goal is to see if t…

This study tests whether fast-acting opioids (fentanyl or morphine) can reduce shortness of breath during physical activity in cancer patients who already take strong painkillers. About 150 adults with active cancer and moderate-to-severe exertional dyspnea will take the drug or …

This study tests whether combining cognitive behavioral therapy with a stimulant, melatonin, and light therapy can improve sleep in cancer patients. About 68 adults currently on cancer treatment who have poor sleep will participate. The goal is to reduce sleep problems, fatigue, …

This study tests whether personalized coaching and mobile apps can help young adult cancer survivors become more physically active and improve their diet. About 374 participants will try different behavioral programs designed to fit their needs. The goal is to see if these progra…

This study looks at how cancer patients view using marijuana products (THC or CBD) along with opioids for pain relief. Researchers will survey 200 patients in Texas and Arizona to understand their preferences and symptom control. The goal is to learn if adding marijuana helps pat…

This study follows nearly 1,900 cancer patients who tested positive for COVID-19 to learn how the virus impacts their health and cancer treatment. Researchers collect blood samples, medical records, and images to identify factors linked to severe COVID-19 and changes in cancer th…

This study looks at whether a dye called iohexol can help doctors better calculate the dose of the chemotherapy drug carboplatin for cancer patients. Researchers will compare different methods of estimating kidney function to see which gives the most accurate dose. The goal is to…

This study surveys 110 parents of children with cancer to learn about their attitudes and beliefs regarding the risks of using opioids for pain. Many parents worry about giving these strong painkillers to their kids, sometimes even skipping doses or stopping early. The goal is to…

This study aimed to understand how often cancer patients with neutropenic fever (a fever with low white blood cells) have serious complications, to see if some could be safely treated at home instead of in the hospital. It planned to review records of low-risk patients treated at…

This study surveys 200 patients and healthcare providers to understand their opinions on using telemedicine (video visits) for radiation oncology. Participants must be 18 or older, English-speaking, and have had at least one telemedicine visit. The goal is to measure satisfaction…

This study looks at how the COVID-19 pandemic impacted the well-being of cancer patients who also have nerve pain (neuropathy). Researchers want to learn about their quality of life and whether a therapy called neurofeedback made any difference. The study involves 274 people who …

This study looks at whether a special program using a mobile app and social media can help teens and young adults who survived childhood cancer become more physically active. About 387 survivors will either use the full program or just a fitness tracker alone. The goal is to see …

This study looks at how immunotherapy drugs affect balance and hearing in people with cancer. Researchers will test 50 patients before and during their standard immunotherapy treatment. The goal is to understand if these treatments cause dizziness or hearing changes, helping doct…

This study surveys over 1,200 cancer patients who took part in earlier behavioral trials to learn how the COVID-19 pandemic impacted their quality of life, mental health, and daily routines. Participants fill out questionnaires about stress, sleep, diet, and exercise. The goal is…

This study looks at whether African American and White cancer patients respond differently to a type of immunotherapy called checkpoint inhibitors. Researchers will collect blood, saliva, and health information from 2,100 patients to compare side effects and treatment success. Th…

This early-phase study tests a new imaging agent called 68Ga-FAPI-46, which targets cells around tumors. About 26 adults with various cancers will receive the tracer and then have a PET/CT scan. The goal is to see where the tracer goes in the body and compare it to standard imagi…

This study looks at whether whole body MRI scans and liquid biopsies (blood tests) are acceptable and useful for finding early cancer in 100 people aged 50 or older who have a strong family history of cancer. Participants will have these tests and answer questions about their exp…

This study looked at how the COVID-19 pandemic impacted the well-being and quality of life of over 13,000 cancer patients and survivors. Researchers used questionnaires to gather information on experiences like exposure to the virus, isolation, and financial disruptions. The goal…

This study looks at how well nutritional check-ups can find malnutrition in older adults with cancer. About 180 participants will undergo special assessments to see if their nutrition affects their health and survival. The goal is to help doctors better identify and address malnu…

This study tests a web-based education tool called HOPE-Genomics that helps cancer patients learn about their genetic test results. About 465 adults with certain cancers (breast, lung, colorectal, and others) will use the tool to see if it improves their understanding of genomics…

This study looks at whether a special online meeting program (called ECHO) can help imaging doctors feel more connected and work more efficiently. About 36 doctors from MD Anderson will take part. The goal is to see if these virtual meetings improve teamwork and job satisfaction.

This study surveys about 1,200 women at a Florida prison to understand their cancer screening history, risk factors, and barriers to care. The information will be used to create a digital education module on screenable cancers and guidelines. The goal is to improve health literac…

This study looks at whether having naturally low testosterone levels increases the risk of dementia, depression, or anxiety. Researchers will analyze genetic data from large biobanks (like UK Biobank) to see if certain genes linked to low testosterone are also linked to these men…

This study collects tissue and blood samples from 2,400 people with early-onset breast, colon, kidney, liver, multiple myeloma, or prostate cancer. Researchers will analyze the samples to find genetic changes that may cause cancer at a young age, especially in racially and ethnic…

This study tests a symptom questionnaire designed for teenagers with cancer. Researchers interview teens aged 13-17 to see if the survey is easy to use and accurately captures their symptoms. The goal is to improve the tool so doctors can better understand and manage what teens g…

This study tests a mobile app called Oncpatient designed to help cancer patients manage their radiation therapy. Radiation treatment can be confusing, with complex schedules and side effects. The app provides easy-to-access information and guidance. Researchers want to see if pat…

This study looks at whether a program of exercise and a dietary supplement called nicotinamide riboside (similar to vitamin B3) can improve muscle health and insulin resistance in adults who survived childhood cancer and now have prediabetes. About 20 participants will take part …

This study aims to understand why minority cancer patients often do not take part in clinical trials. Researchers will survey 590 patients to learn about their challenges and preferences. The information will be used to create a personalized educational platform to help these pat…

This study tracks how the immune systems of 549 children, teens, and young adults with cancer respond to COVID-19 vaccination. Cancer and its treatments can weaken immunity, so researchers want to see if factors like vaccine type, timing, and booster doses affect protection. The …

This study looks at the financial challenges people face after a cancer diagnosis. Researchers are surveying 625 English- or Spanish-speaking adults diagnosed within the past year to understand what factors contribute to financial stress. The goal is to identify targets for futur…

This study compares a new dosing method for the cancer drug vincristine in infants and young children to the standard method used in older children. The goal is to see if the new approach gives similar drug levels in the blood with fewer side effects. About 83 children up to 12 y…

This study looks at whether training and supporting cancer clinic staff can help them give a special health check-up (called a geriatric assessment) to adults aged 65 and older before they start a new cancer therapy. The check-up covers physical health, social support, and daily …

This study collects tissue and blood samples, along with medical information, from 1,600 people with various advanced cancers. Researchers will store and study these samples over time to learn how cancer changes and why some treatments stop working. The goal is to improve future …

This study compares a new PET-CT scanner (RefleXion) to the standard one for people with various cancers. About 20 adults will get both scans to see if the new one finds the same tumors. If it works well, patients may need fewer scans before radiation therapy.

This study looks at how cancer patients perceive their doctor's empathy during the COVID-19 pandemic. It compares in-person visits where doctors wear protective gear (like masks) to video calls where doctors do not wear masks. The goal is to see which way of communicating makes p…