Can a natural supplement soothe chemo nerve damage?

NCT ID NCT05246670

Ongoing Symptom relief Sponsor: Academic and Community Cancer Research United Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This phase II trial tests whether a natural supplement called PEA can relieve nerve pain, numbness, and tingling caused by chemotherapy in cancer patients. About 88 adults who have had nerve symptoms for at least 3 months after chemo will take PEA or a placebo for 8 weeks. The study measures changes in symptom severity using a standard questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PEA (Palmitoylethanolamide), a natural supplement
What this could lead to: If it works, this could point toward a safe, non-drug option to relieve nerve pain and numbness from chemotherapy.
What could go wrong: This is a small, early-phase pilot trial with only 88 participants. The supplement may not work better than a placebo, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cancer chemotherapy-induced neuropathy hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY HEMATOPOIETIC AND LYMPHOID CELL NEOPLASM MALIGNANT SOLID NEOPLASM

Contacts and locations

Locations

Carle Cancer Center NCI Community Oncology Research Program

Urbana, Illinois, 61801, United States
Cone Health Cancer Center

Greensboro, North Carolina, 27403, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mayo Clinic Health System Eau Claire Hospital-Luther Campus

Eau Claire, Wisconsin, 54703, United States
Mayo Clinic Health System-Franciscan Healthcare

La Crosse, Wisconsin, 54601, United States
Middlesex Hospital

Middletown, Connecticut, 06457, United States
Rapid City Regional Hospital

Rapid City, South Dakota, 57701, United States
Siouxland Regional Cancer Center

Sioux City, Iowa, 51101, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.