HODGKIN LYMPHOMA

This is the first study in people testing a new drug called CTX-8371 for several advanced cancers that have stopped responding to standard treatments. Researchers will give increasing doses to a small group of patients to check if the drug is safe and what side effects it causes.…

This study is testing a modified, gentler two-step method to prepare patients for a stem cell transplant. The goal is to reduce the risk of death from the transplant procedure itself for people with various blood cancers and disorders. Researchers are comparing two lower-intensit…

This study is testing a stem cell transplant from a partially matched family donor for patients with hard-to-treat blood cancers like leukemia and lymphoma. Before the transplant, patients receive chemotherapy and radiation to wipe out their own bone marrow and cancer cells. The …

This study is testing a drug called tislelizumab as a first treatment for older adults with Hodgkin lymphoma who are not healthy enough for standard chemotherapy. The goal is to see if this single, immunotherapy drug can effectively control the cancer with fewer side effects. Res…

This early-stage study is testing a new version of a cancer treatment called CAR-T cell therapy for people whose lymphomas have returned or not responded to standard treatments. Researchers are using pre-made immune cells from healthy donors, modified to better target a protein (…

This study is testing a new, personalized approach to treating advanced Hodgkin lymphoma. It uses an early scan to see how well the initial treatment is working, then adjusts the follow-up therapy based on those results. The goal is to control the cancer effectively while trying …

This study is testing a stem cell transplant procedure that does not use radiation to prepare the body. It aims to control Hodgkin and non-Hodgkin lymphoma in patients whose cancer has returned or is hard to treat, including people living with HIV. Researchers will compare how lo…

This early study is testing if a drug called Darzalex Faspro can safely lower harmful antibodies in patients with blood cancers. Lowering these antibodies may allow patients who are currently ineligible to receive a potentially life-saving stem cell transplant from a donor. The s…

This study is testing a combination of four drugs for adults in India with advanced Hodgkin lymphoma who haven't had any previous treatment. The main goal is to check how safe this treatment is and how well it works to control the cancer. Participants will receive the drug combin…

This study is testing a new cell therapy for patients whose blood cancers have returned or not responded to standard treatments. Researchers are giving patients specially engineered immune cells, called NK cells, which come from donated cord blood. The goal is to see if these mod…

This study is testing if a new combination of two drugs (pembrolizumab and brentuximab vedotin) works better than the current standard treatment for classical Hodgkin lymphoma that has come back or not responded to initial chemotherapy. The goal is to shrink or eliminate the canc…

This study is testing a combination of two drugs, nivolumab and ruxolitinib, for adults whose Hodgkin lymphoma has returned or not responded to prior treatments. The first part aims to find the safest dose of ruxolitinib to give with nivolumab. The second part will see how well t…

This study is testing a combination of two immunotherapy drugs, nivolumab and axatilimab, for adults with classical Hodgkin lymphoma that has come back or hasn't responded to previous treatments, including similar immunotherapies. The main goals are to see if the combination is s…

This study is testing whether adding the immunotherapy drug pembrolizumab to a standard chemotherapy regimen (called GVD) is safe and effective for adults with Hodgkin lymphoma that has returned or did not respond to first treatment. The goal is to control the cancer and see if t…

This study is observing how well the medication brentuximab vedotin works for adults with Hodgkin's lymphoma who have undergone stem cell transplants. Researchers will follow 70 participants in Poland for two years to see how long they remain cancer-free and monitor treatment saf…

This large international trial is comparing two chemotherapy combinations (ABVD vs A2VD) for people with newly diagnosed, early-stage Hodgkin lymphoma. The study uses PET scans after two treatment cycles to personalize further therapy—some patients receive less treatment, some ge…

This study is comparing two different first-line treatment approaches for advanced Hodgkin lymphoma. One group receives a newer combination of immunotherapy (nivolumab) with chemotherapy (AVD), while the other receives standard chemotherapy regimens. The main goal is to see if th…

This study provides access to cord blood units that are not yet FDA-approved for patients who need a transplant for blood cancers or other serious blood/immune disorders. It aims to see how well patients' immune systems recover after receiving these transplants and to monitor for…

This program provides access to an experimental drug called AVM0703 for patients with various solid tumors and blood cancers. It is for people who may not have other treatment options. The drug aims to help the body's immune system fight cancer, and early reports show mostly mild…

This study is testing whether a combination of four different immunotherapy and targeted therapy drugs can help control two types of B-cell lymphoma that have returned after prior treatment. It will enroll about 36 adults whose lymphoma has progressed despite at least one previou…

This study is testing the safety of a new type of stem cell transplant for children whose cancers have come back or are very hard to treat. Doctors use a half-matched family donor and a special process to remove certain immune cells from the transplant, aiming to reduce complicat…

This study is testing a new approach to collecting a patient's own stem cells for a transplant to treat blood cancers like multiple myeloma and lymphoma. The goal is to see if using a standard drug (G-CSF) first and only adding a second drug (Plerixafor) if needed can successfull…

This study is testing a shorter version of a powerful six-drug chemotherapy combination (called BrECADD) for adults with advanced Hodgkin lymphoma. The main goal is to see if this shorter treatment plan can effectively control the cancer while being more tolerable for patients. R…

This study is testing a new type of cell therapy for Hodgkin lymphoma that has come back or hasn't responded to standard treatments. Researchers are modifying a patient's own immune cells to better find and attack the cancer cells. The trial aims to find a safe dose and see how w…

This early-stage trial is testing a new vaccine designed to prevent serious cytomegalovirus (CMV) infections. The study involves patients with blood cancers who are receiving a stem cell transplant from a partially matched donor, a procedure that carries a high risk of CMV. Resea…

This study is testing a new vaccine approach to prevent a common and serious viral infection called CMV in patients receiving a stem cell transplant for blood cancers. Researchers are giving the vaccine to the healthy stem cell donors, hoping the donor's boosted immunity will be …

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study is testing whether a personalized exercise program can help lymphoma and breast cancer patients maintain their physical fitness, heart function, and quality of life during cancer treatment. Researchers will compare two approaches: one group will follow a structured phy…

This study is testing whether following a Mediterranean diet and doing home-based exercise during chemotherapy can help lymphoma patients better complete their treatment and reduce treatment-related side effects. Researchers will enroll 140 adults with lymphoma who are starting c…

This study aims to understand how personal relationships and physical activity affect the well-being of young adults who have survived cancer. Researchers will follow 250 young adult survivors for one year, having them complete surveys and wear activity trackers. The goal is to l…

This study is testing whether a research method is practical and acceptable for young patients (ages 6-25) newly diagnosed with Hodgkin or Non-Hodgkin lymphoma. It involves giving small 'probe' medications at scheduled hospital visits and taking blood samples to see how the body …

This study aims to discover new genes that cause cancer to run in families, especially those affecting children. Researchers will collect health information, blood, and sometimes leftover tumor samples from families where multiple members have had cancer. The goal is to build a l…

This study aims to understand how a cancer drug called venetoclax works in the body when it's given as a liquid made from crushed tablets. It will enroll up to 30 children and young adults with blood cancers who are already receiving this liquid form because they cannot swallow p…

This study aims to understand why some young Hodgkin lymphoma survivors develop heart problems years after their cancer treatment. Researchers will check blood samples for specific markers and perform heart scans on 190 survivors who received certain chemotherapy drugs. The goal …

This research aims to understand how social factors and genetics affect long-term health in young adults who have survived Hodgkin or Non-Hodgkin lymphoma. The study will follow 2,000 survivors for two years, collecting blood samples and survey data about their quality of life, s…

This study aims to understand why some young women develop early menopause after chemotherapy for breast cancer or lymphoma, while others do not. Researchers will analyze stored ovarian tissue from 50 patients to look for genetic differences between the two groups. The goal is to…