HODGKIN LYMPHOMA

This study is testing whether adding the immunotherapy drug nivolumab to standard ABVD chemotherapy can improve cure rates for people with high-risk Hodgkin lymphoma. The trial focuses on patients whose cancer shows signs of being resistant after initial chemotherapy. Researchers…

This study is for children and young adults (up to age 21) with high-risk blood cancers like leukemia and lymphoma. It tests a modified blood cell transplant from a partially matched family donor. The donor cells are processed in a lab to remove certain immune cells that can caus…

This early-stage trial is testing whether adding specially treated immune cells, called 'veto cells,' can help patients with blood cancers or bone marrow disorders after a stem cell transplant from a half-matched donor. The goal is to help the donor's cells grow and work in the p…

This study is testing whether a shorter, 8-week chemotherapy regimen works as well as longer treatments for children with favorable-risk Hodgkin lymphoma. Some patients who still show cancer after chemotherapy also receive targeted, low-dose radiation. The goal is to effectively …

This study is testing whether a drug called tislelizumab, when combined with standard chemotherapy, works as well as the usual intensive treatment for Hodgkin lymphoma that has returned or didn't respond to first-line therapy. The trial involves 75 adults aged 18-70. The goal is …

This study is testing whether adding the drug ipilimumab to the approved drug nivolumab can help control Hodgkin lymphoma that has come back or stopped responding to other treatments. It will involve about 13 adults whose cancer got worse after a prior type of immunotherapy. Part…

This study is testing different combinations of chemotherapy drugs for children and young adults with Hodgkin lymphoma, based on how advanced their cancer is. The goal is to control the disease and prevent it from coming back. Doctors will also closely monitor side effects and th…

This study is testing whether specially grown cord blood stem cells can help patients with high-risk blood cancers recover their immune systems faster after a transplant. Participants receive a transplant using these expanded stem cells after strong chemotherapy. Researchers are …

This study is testing whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can help children and young adults with newly diagnosed Hodgkin lymphoma who are not responding well enough to initial chemo alone. The trial will enroll about 340 participants to s…

This study is testing a new combination of two drugs, cobolimab and dostarlimab, for children and young adults with advanced solid tumors that have not responded to other treatments. The main goals are to find the safest and most effective dose and to see how well the body tolera…

This study is testing whether a shorter course of radiation treatment is safe for adults whose Hodgkin or non-Hodgkin lymphoma has returned or not responded to standard treatments. Instead of the usual 5-6 weeks of radiation, researchers aim to find the highest safe dose that can…

This study is testing a well-established cancer treatment plan, originally developed in the U.S., on Chinese children and teenagers newly diagnosed with Hodgkin lymphoma. The goal is to see if this plan works as effectively in China, where the disease is rarer and drug access can…

This study is testing a combination of four drugs (brentuximab vedotin, pembrolizumab, doxorubicin, and dacarbazine) for people with advanced or bulky Hodgkin lymphoma who haven't had treatment before. Researchers are using PET scans during treatment to see if they can adjust the…

This early-stage study is testing whether immune cells from healthy donors, given along with two other drugs, are safe for people with advanced colorectal, stomach, or hard-to-treat blood cancers. The goal is to see if this combination helps the donor immune cells last longer in …

This is an early-stage study testing a new antibody drug called IMT-009 in people with advanced solid tumors or lymphomas that have stopped responding to standard treatments. The main goals are to find a safe dose, understand the side effects, and see if the drug helps shrink tum…

This study is testing a new type of imaging scan to see if it can better detect and monitor tumors in children and young adults with cancer. The scan uses a radioactive form of a natural protein building block called methionine. Researchers want to see how well this new scan work…

This study is testing a new approach to prevent a common and dangerous viral infection called CMV in people receiving a stem cell transplant for blood cancer. Researchers are giving a vaccine to the healthy stem cell donors before the transplant. The goal is to see if the donor's…

This study is testing a vaccine designed to prevent cytomegalovirus (CMV) infection in adults with blood cancers who are receiving a half-matched stem cell transplant. CMV is a common virus that can become life-threatening when the immune system is weakened after transplant. The …

This study is testing whether a home-based light therapy device, used alongside computer brain training games, can help improve memory, attention, and thinking skills in adult survivors of childhood leukemia or Hodgkin's lymphoma. Participants use the device at home three times a…

This study aims to understand how common obstructive sleep apnea is in adult survivors of Hodgkin lymphoma who were treated with chest radiation. Researchers will compare 220 survivors to a group of healthy people matched for age, gender, race, and weight. The study involves slee…

This study is collecting and analyzing real-world medical information from 400 elderly patients in China who have Hodgkin lymphoma. The goal is to understand the disease better in this age group and create a tool to help doctors predict how individual patients might fare. The stu…

This study aims to understand why people who survive a blood cancer transplant have a higher risk of heart disease. Researchers will closely monitor 350 adult patients' heart, lung, and muscle function before their transplant and for two years after. The goal is to learn how thes…

This study is testing a new system designed to give doctors a more complete picture of an older patient's overall health and life circumstances when planning cancer treatment. It combines questions about aging, daily function, mental health, and social needs like housing and food…

This study aims to understand why many young adults who survived childhood cancer experience early signs of aging and frailty, which can lead to serious health problems later in life. Researchers will follow over 1,500 survivors for five years, measuring their physical fitness an…

This study is testing a new blood test, called a 'liquid biopsy,' to see if it can better predict whether lymphoma will come back after initial treatment. It will compare the blood test results to the standard PET-CT scan in 108 patients with B-cell or Hodgkin lymphoma. The goal …