Blood test may replace scans for lymphoma monitoring

NCT ID NCT06744075

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a blood test that looks for tumor DNA (called ctDNA) can predict if lymphoma will come back after first treatment. Researchers will compare this 'liquid biopsy' to standard PET scans in 108 adults with B-cell or Hodgkin lymphoma. The goal is to see if the blood test is more accurate at forecasting outcomes at 1 and 2 years, which could eventually help doctors decide if patients need more or less treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this could make ctDNA clearance a standard way to predict lymphoma progression, helping doctors tailor treatment intensity for each patient.

What could go wrong

This is an observational study, not a treatment trial. The blood test may not prove more accurate than current PET scans, and results may not change practice without larger studies.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

B-cell neoplasm classic Hodgkin lymphoma follicular lymphoma high grade B-cell lymphoma Hodgkins lymphoma large B-cell lymphoma lymphoma mantle cell lymphoma marginal zone lymphoma Neoplasm, Residual nodular lymphocyte predominant Hodgkin lymphoma primary mediastinal large B-cell lymphoma T-cell/histiocyte rich large B cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Centre Henri Becquerel

    Rouen, 76038, France

  • Hôpital Jacques Monod

    Montivilliers, 76290, France