New hope for kids with hodgkin lymphoma: tailored chemo aims to cut toxicity

NCT ID NCT03755804

Ongoing Disease control Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 study is testing a risk-adapted approach for children and young adults with classical Hodgkin lymphoma. Depending on their risk level, patients receive different combinations of chemotherapy drugs, with the goal of improving response while reducing side effects. The trial enrolls 232 participants up to age 25 and uses imaging after two cycles to guide further treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bendamustine, etoposide, doxorubicin, bleomycin, vincristine, vinblastine, prednisone, filgrastim, brentuximab vedotin, cyclophosphamide, dacarbazine
What this could lead to: If successful, this could lead to more effective and less toxic chemotherapy regimens for children and young adults with Hodgkin lymphoma, improving survival and reducing long-term side effects.
What could go wrong: This is a phase 2 trial, so results are still preliminary. The treatments involve strong chemotherapy drugs with known side effects like infection, nerve damage, and heart problems. Not all patients may respond adequately.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

classic Hodgkin lymphoma Hodgkins lymphoma neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HODGKIN LYMPHOMA

Contacts and locations

Locations

Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Lucile Packard Children's Hospital Stanford University

Palo Alto, California, 94304, United States
Maine Children's Cancer Program

Scarborough, Maine, 04074, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
St. Jude Affiliate Baton Rouge Clinic (Our Lady of the Lakes Regional Medical Center)

Baton Rouge, Louisiana, 70809, United States
St. Jude Affiliate Clinic at Novant Health Hemby Children's Hospital

Charlotte, North Carolina, 28204, United States
St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
St. Jude Midwest Affiliate - Peoria

Peoria, Illinois, 61637, United States

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