New drug combo targets Hard-to-Treat lymphomas

NCT ID NCT06137144

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called AZD3470, alone or with pembrolizumab (Keytruda), in people with certain blood cancers like lymphoma. The goal is to check safety, side effects, and whether the drug shrinks tumors. About 161 adults and teens will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

AZD3470 (a PRMT5 inhibitor) and pembrolizumab (Keytruda)

What this could lead to

If successful, this could point toward a new treatment option for certain blood cancers like lymphoma.

What could go wrong

This is an early-phase trial (Phase 1/2) with a small number of participants, so the drug may not prove effective or safe enough for wider use. Side effects are unknown at this stage.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

anaplastic large cell lymphoma angioimmunoblastic T-cell lymphoma classic Hodgkin lymphoma Hodgkins lymphoma lymphoma mature T-cell and NK-cell non-Hodgkin lymphoma non-Hodgkin lymphoma peripheral T-cell lymphoma, not otherwise specified

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AITL ALCL HODGKIN LYMPHOMA LYMPHOMA NON HODGKIN LYMPHOMA PERIPHERAL T-CELL LYMPHOMA (PTCL) PTCL-NOS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Research Site
NOT_YET_RECRUITING

Duarte, California, 91010, United States
Research Site
RECRUITING

Miami, Florida, 33136, United States
Research Site
WITHDRAWN

Atlanta, Georgia, 30322, United States
Research Site
RECRUITING

Boston, Massachusetts, 02215, United States
Research Site
NOT_YET_RECRUITING

Boston, Massachusetts, 02215, United States
Research Site
NOT_YET_RECRUITING

New York, New York, 10016, United States
Research Site
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Research Site
RECRUITING

Houston, Texas, 77030, United States
Research Site
WITHDRAWN

Adelaide, 5000, Australia
Research Site
WITHDRAWN

Birtinya, 4575, Australia
Research Site
NOT_YET_RECRUITING

Fitzroy, 3065, Australia
Research Site
RECRUITING

Nedlands, 6009, Australia
Research Site
WITHDRAWN

South Brisbane, 4101, Australia
Research Site
WITHDRAWN

Waratah, 2298, Australia
Research Site
NOT_YET_RECRUITING

Beijing, 100191, China
Research Site
NOT_YET_RECRUITING

Guangzhou, 510060, China
Research Site
NOT_YET_RECRUITING

Shanghai, 20032, China
Research Site
TERMINATED

Créteil, 94010, France
Research Site
NOT_YET_RECRUITING

Dijon, 21079, France
Research Site
RECRUITING

Lille, 59000, France
Research Site
RECRUITING

Pierre-Bénite, 69310, France
Research Site
RECRUITING

Villejuif, 94805, France
Research Site
NOT_YET_RECRUITING

Berlin, 12203, Germany
Research Site
RECRUITING

Cologne, 50937, Germany
Research Site
NOT_YET_RECRUITING

Erlangen, 91054, Germany
Research Site
NOT_YET_RECRUITING

Würzburg, 97080, Germany
Research Site
RECRUITING

Alessandria, 15100, Italy
Research Site
RECRUITING

Bologna, 40138, Italy
Research Site
RECRUITING

Milan, 20141, Italy
Research Site
NOT_YET_RECRUITING

Bunkyō City, 113-8677, Japan
Research Site
NOT_YET_RECRUITING

Kōtoku, 135-8550, Japan
Research Site
RECRUITING

Seoul, 03080, South Korea
Research Site
RECRUITING

Seoul, 06351, South Korea
Research Site
RECRUITING

L'Hospitalet de Llobregat, 08908, Spain
Research Site
RECRUITING

Madrid, 28041, Spain
Research Site
RECRUITING

Manchester, M20 4BX, United Kingdom
Research Site
RECRUITING

Oxford, OX3 7LE, United Kingdom