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New dengue vaccine trial targets older adults and those with chronic illness

NCT ID NCT06579755

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial is testing a dengue vaccine (TDV) in 800 adults aged 45 to 79, including those with diabetes, high blood pressure, or kidney disease. Participants will receive two shots three months apart. The study aims to check for side effects and measure the immune response, especially in older adults and people with other health conditions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Dengue Tetravalent Vaccine (TDV, also known as TAK-003)
What this could lead to
If successful, this could provide a safe and effective dengue vaccine for older adults and those with health conditions like diabetes or high blood pressure.
What could go wrong
This is an early-stage safety and immune response study, not yet proving the vaccine prevents dengue. Side effects like injection site pain or fever are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dengue disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DENGUE FEVER

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Associacao Obras Sociais Irma Dulce Hospital Santo Antonio

    RECRUITING

    Salvador, Estado de Bahia, 40444-130, Brazil

  • Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto Hospital de Base - PPDS

    RECRUITING

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • Fundacion Huesped - PPDS

    RECRUITING

    Buenos Aires, C1427CEA, Argentina

  • Hospital for Tropical Diseases

    RECRUITING

    Ratchathewi, Krung Thep Maha Nakhon-Bangkok, 10400, Thailand

  • Ramathibodi Hospital

    RECRUITING

    Ratchathewi, Bangkok, 10400, Thailand

  • Singapore General Hospital (SGH)

    RECRUITING

    Singapore, 169608, Singapore

  • Tan Tock Seng Hospital

    RECRUITING

    Singapore, 308433, Singapore

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