Dengue vaccine booster put to the test: can it shield against all four virus types?

NCT ID NCT03999996

Completed ⭐️ VACCINE ⭐️ Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This Phase 3 trial is testing whether a booster dose of Takeda's tetravalent dengue vaccine can strengthen and prolong immunity against all four dengue virus types. Healthy adolescents and adults who previously received the vaccine in earlier studies are being followed to see how long their antibodies last and whether a booster shot improves their immune response. The study aims to help protect people living in or traveling to areas where dengue is not common.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Takeda's tetravalent dengue vaccine (live, attenuated) given as a booster shot
What this could lead to: If the booster works, it could provide longer-lasting protection against all four types of dengue virus for people living in or traveling to areas where dengue is not common.
What could go wrong: This is a follow-up study with a small number of participants, and the booster may not produce a strong enough immune response against all four virus types. The vaccine could also cause side effects like injection-site reactions or fever.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dengue disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DENGUE FEVER

Contacts and locations

Locations

AES - DRS - Optimal Research Alabama - Huntsville

Huntsville, Alabama, 35802, United States
AES - DRS - Optimal Research Illinois - Peoria

Peoria, Illinois, 61614, United States
AES - DRS - Synexus Clinical Research US, Inc. - Omaha

Papillion, Nebraska, 68046, United States
AES - DRS - Synexus Clinical Research US, Inc. - St. Louis

St Louis, Missouri, 63141, United States
AES - DRS - Synexus Clinical Research US, Inc. Minneapolis

Richfield, Minnesota, 55423-2590, United States
Advanced Clinical Research/Velocity Clinical Research

West Jordan, Utah, 84088-8865, United States
Alliance for Multispecialty Research, LLC - Newton - PPDS

Newton, Kansas, 67114, United States
CAIMED Investigacion en Salud S.A de C.V.

Mexico City, 06760, Mexico
Instituto Nacional de Pediatria

Mexico City, 04530, Mexico
Optima Research

Rockville, Maryland, 20850, United States

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