New drug aims to stop liver scarring in Alpha-1 patients
NCT ID NCT06165341
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a medicine called fazirsiran for people with Alpha-1 antitrypsin deficiency who already have mild liver scarring. The drug works by reducing the buildup of an abnormal protein in the liver that causes damage. About 50 participants will receive either fazirsiran or a placebo for around 2 years, and researchers will check safety and whether the drug slows or reverses liver scarring.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Bon Secours St. Mary's Hospital
RECRUITINGNewport, Virginia, 23602-4414, United States
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Boston Medical Center
RECRUITINGBoston, Massachusetts, 02118-2335, United States
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CCA Hospital Braga
RECRUITINGBraga, 4710-243, Portugal
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Centro Hospitalar de Universitário de Santo António E.P.E
RECRUITINGPorto, 4099-001, Portugal
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Charité - Campus Virchow-Klinikum
RECRUITINGBerlin, 13353, Germany
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032-3722, United States
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Fondazione IRCCS Policlinico San Matteo
RECRUITINGPavia, 27100, Italy
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Hannover Medical School
RECRUITINGHanover, 30625, Germany
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Henry Ford Health System
RECRUITINGNovi, Michigan, 48377-3600, United States
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Hopital PONTCHAILLOU CHU de Rennes
RECRUITINGRennes, 35000, France
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Hospital Dr. Nélio Mendonça
RECRUITINGFunchal, 9000-168, Portugal
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Hospital Universitario Virgen del Rocio - PPDS
RECRUITINGSeville, 41018, Spain
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Hôpital Paul Brousse
RECRUITINGVal-de-Marne, 94800, France
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Hôpital de La Croix Rousse
RECRUITINGLyon, 69317, France
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ID Clinic Arkadiusz Pisula
WITHDRAWNMysłowice, 41-400, Poland
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Indiana University School of Medicine-Indianapolis
RECRUITINGIndianapolis, Indiana, 46202-2266, United States
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Inspiration Research Limited
RECRUITINGToronto, Ontario, M5T 3A9, Canada
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KABEG - Klinikum Klagenfurt Am Wörthersee
RECRUITINGKlagenfurt, 9020, Austria
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Karolinska Universitetssjukhuset Huddinge
RECRUITINGHuddinge, 14186, Sweden
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King's College Hospital
RECRUITINGLondon, SE5 9RS, United Kingdom
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LKH-Universitätsklinikum Graz
RECRUITINGGraz, 8036, Austria
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Mayo Clinic - PPDS
RECRUITINGPhoenix, Arizona, 85054-4502, United States
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Mayo Clinic PPDS
RECRUITINGRochester, Minnesota, 55905, United States
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NYU Langone Medical Center
RECRUITINGNew York, New York, 10016-6402, United States
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Peak Gastroenterology Associates
RECRUITINGColorado Springs, Colorado, 80907, United States
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Penn State Health Milton S. Hershey Medical Center
RECRUITINGHershey, Pennsylvania, 17033-2360, United States
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Schiff Center for Liver Diseases/University of Miami
RECRUITINGMiami, Florida, 33136, United States
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St Joseph's Hospital and Medical Center
RECRUITINGPhoenix, Arizona, 85013-4224, United States
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Texas Liver Institute American Research Corporation
RECRUITINGSan Antonio, Texas, 78215, United States
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UCLA Pulmonary and Critical Care
RECRUITINGLos Angeles, California, 90095-3075, United States
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UZ Antwerpen
RECRUITINGAntwerp, 2650, Belgium
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UZ Leuven
RECRUITINGLeuven, 3000, Belgium
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University Hospitals Cleveland Medical Center
RECRUITINGCleveland, Ohio, 44106-1716, United States
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University Of Iowa Hospitals And Clinics
RECRUITINGIowa City, Iowa, 52242-1009, United States
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University of Arizona Thomas D. Boyer Liver Institute
RECRUITINGTucson, Arizona, 85724-0001, United States
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University of California Benioff Children's Hospital
RECRUITINGSan Francisco, California, 94143-2203, United States
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University of California San Diego
RECRUITINGLa Jolla, California, 92037-1337, United States
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University of Michigan Hospital - 1500 E Medical Center Dr
RECRUITINGAnn Arbor, Michigan, 48109, United States
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Universitätsklinikum Tübingen
RECRUITINGTübingen, 72076, Germany
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Universitätsklinikum der RWTH Aachen
RECRUITINGAachen, 52074, Germany
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Universitätsspital Bern
RECRUITINGBern, 3010, Switzerland
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More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a higher dose slow lung damage in Alpha-1 patients?
- New shot method for Alpha-1 lung disease shows promise in early trial
- 500 adults to help unravel mysteries of rare liver disease
- New drug could slow liver damage in rare genetic disease
- New drug shows promise for slowing liver damage in rare genetic disease