New pill could ease psoriatic arthritis pain in major trial

NCT ID NCT06671496

Recruiting now Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 6 times

Summary

This Phase 3 trial tests whether the experimental drug zasocitinib (TAK-279) can reduce joint swelling and pain in people with active psoriatic arthritis. About 600 adults will receive either the drug or a placebo for up to 60 weeks. The main goal is to see if more people on the drug achieve at least a 20% improvement in arthritis symptoms by week 16.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Zasocitinib (TAK-279) tablets
What this could lead to: If it works, this could provide a new daily pill option to control joint and skin symptoms in people with psoriatic arthritis.
What could go wrong: This is a Phase 3 trial, so earlier results were promising, but the drug may still fail to show benefit or cause side effects. It requires ongoing daily dosing, not a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

psoriatic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PSORIATIC ARTHRITIS

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

AARR- Kansas City Physician Partners
RECRUITING

Kansas City, Missouri, 85032, United States
AARR- Lone Star Arthritis & Rheumatology Associates
RECRUITING

Fort Worth, Texas, 76109, United States
APRILLUS Asistencia e Investigacion Clinica
RECRUITING

Buenos Aires, C1406AGA, Argentina
Accellacare Alcobendas
RECRUITING

Alcobendas, Madrid, 28100, Spain
Advanced Rheumatology PC | Lansing, MI
RECRUITING

Lansing, Michigan, 48910-5894, United States
Advanced Rheumatology of Houston - The Woodlands
RECRUITING

The Woodlands, Texas, 77382, United States
Affiliated Hospital of Nantong University
RECRUITING

Nantong, Jiangsu, 226001, China
Altoona Center for Clinical Research | Ducansville, PA
RECRUITING

Duncansville, Pennsylvania, 16635, United States
Arizona Arthritis & Rheumatology Research, PLLC | Phoenix, AZ
RECRUITING

Mesa, Arizona, 85210, United States
Arizona Arthritis & Rheumatology Research, PLLC | Phoenix, AZ
RECRUITING

Phoenix, Arizona, 85032, United States
Arizona Arthritis & Rheumatology Research, PLLC | Phoenix, AZ
RECRUITING

Tucson, Arizona, 85748, United States
BayCare Medical Group
RECRUITING

St. Petersburg, Florida, 33705, United States
Biopharma Informatic | Hassan
RECRUITING

Houston, Texas, 77089, United States
Biovin Enterprises LLC dba Medvin Clinical Research | Covina, CA
RECRUITING

Covina, California, 91722, United States
CEPIC - Centro Paulista de Investigacao Clinica
RECRUITING

São Paulo, 04266-010, Brazil
CER San Juan, Centro Polivalente de Asistencia e Investigacion Clinica
RECRUITING

San Juan, 5400, Argentina
CHRU de Tours
RECRUITING

Tours, Indre Et Loire, 37044, France
CHU Toulouse
RECRUITING

Toulouse, Haute Garonne, 31059, France
CHU de Reims
RECRUITING

Reims, Marne, " 51100", France
CIMER
RECRUITING

San Miguel de Tucumán, Tucumán Province, T4000, Argentina
CMIP-Centro Mineiro de Pesquisa Ltda
RECRUITING

Juiz de Fora, Minas Gerais, 36010-570, Brazil
Central South University - Xiangya School of Medicine - Zhuzhou Central Hospital
RECRUITING

Zhuzhou, Hunan, 412007, China
Centro de Investigaciones Reumatologicas
RECRUITING

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Centrum Kliniczno Badawcze | Elblag, Poland
RECRUITING

Elblag, Warmian-Masurian Voivodeship, 82-300, Poland
Centrum Medyczne ALL-MED Badania Kliniczne | Krakow, Poland
RECRUITING

Krakow, Lesser Poland Voivodeship, 30-033, Poland
Centrum Medyczne Pratia Gdynia
RECRUITING

Gdynia, Pomeranian Voivodeship, 81-338, Poland
Clinic of Robert Hozman
COMPLETED

Skokie, Illinois, 60076, United States
Clinica Regional del Sud S.A.
RECRUITING

Río Cuarto, Córdoba Province, X5804GAO, Argentina
Clinical Research Center Sp z o o Medic-R Sp K
RECRUITING

Poznan, Wielkopolska, 61-731, Poland
Clinique de l'Infirmerie Protestante
RECRUITING

Caluire-et-Cuire, Auvergne-Rhône-Alpes, 69300, France
Colin Bayliss Research and Teaching Unit
RECRUITING

Victoria Park, Western Australia, WA 6100, Australia
Consultora Integral de Salud Centro Medico Privado SRL | Cordoba, Argentina
RECRUITING

Córdoba, X5000, Argentina
Coventry and Warwickshire Partnership NHS Trust
RECRUITING

Coventry, West Midlands, CV2 2DX, United Kingdom
DJL Clinical Research | Charlotte, NC
RECRUITING

Charlotte, North Carolina, 28210, United States
Direct Helpers Medical Center
RECRUITING

Hialeah, Florida, 33012, United States
EDUMED - Educacao em Saude SS Ltda
RECRUITING

Curitiba, Paraná, 80440-210, Brazil
Fiona Stanley Hospital
RECRUITING

Palmyra Dc, Western Australia, 6961, Australia
First Hospital of Shanxi Medical University
RECRUITING

Taiyuan, Shanxi, 030001, China
Fukuoka University Hospital
RECRUITING

Fukuoka, Hukuoka, 814-0180, Japan
G.R.M.O. Inc.
RECRUITING

Québec, Quebec, G1V 3M7, Canada
Graves Gilbert Clinic
RECRUITING

Bowling Green, Kentucky, 42101, United States
Guangzhou First People's Hospital
RECRUITING

Guangzhou, Guandong, 519180, China
Haywood Hospital
RECRUITING

Stoke-on-Trent, ST6 7AG, United Kingdom
Hokkaido University Hospital
RECRUITING

Sapporo, Hokkaido, 060-8648, Japan
Hopital Nord
RECRUITING

Saint-Etienne, 13015, France
Hospital General de Agudo Jose Maria Ramos Mejia
WITHDRAWN

Buenos Aires, C1221ADC, Argentina
Hospital Quirónsalud Sagrado Corazón
RECRUITING

Seville, 41013, Spain
Hospital Universitario Araba - Sede Hospital Txagorritxu
RECRUITING

Vitoria-Gasteiz, Basque Country, 1009, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Marques de Valdecilla | Rheumatology Department
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Universitario de Canarias
RECRUITING

Santa Cruz de Tenerife, 38320, Spain
Hospital de Base | Centro Integrado de Pesquisa Funfarme - Rheumatology Department
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
IRIS Research and Development | Plantation, FL
RECRUITING

Plantation, Florida, 33324, United States
ISA - Interdisciplinary Study Association
RECRUITING

Berlin, 10789, Germany
Inner Mongolia University of Science and Technology (IMUST) - Baotou Medical College (BMC) - First Affiliated Hospital
RECRUITING

Baotou Shi, Inner Mongolia, 014010, China
Instituto de Investigaciones Clinicas Quilmes
RECRUITING

Quilmes, Buenos Aires, B1878, Argentina
Jiangxi Pingxiang People's Hospital
RECRUITING

Pingxiang, Pingxiang, Pingxiang, China
Jiujiang No.1 People's Hospital
RECRUITING

Jiujiang Shi, Jiangxi, 332000, China
Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21205, United States
King's College Hospital
RECRUITING

London, Greater London, SE5 9RS, United Kingdom
Kita-Harima Medical Center
RECRUITING

Ono-shi, Hyōgo, 675-1392, Japan
Klinika Reuma Park
RECRUITING

Warsaw, Wybierz Województwo, 02-665, Poland
Kojunkai Social Medical Corporation Daido Clinic
RECRUITING

Minami-ku, Nagoya-shi, Aichi-ken, 457-8511, Japan
Kyorin University Hospital
RECRUITING

Mitaka-shi, Tokyo-To, 181-8611, Japan
LMK Servicos Medicos Sociedade Simples
RECRUITING

Porto Alegre, Rio Grande do Sul, 90480-000, Brazil
Linyi People's Hospital
RECRUITING

Linyi Shi, Shandong, 276000, China
MICS Centrum Medyczne Bydgoszcz
RECRUITING

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-090, Poland
MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH - Hamburg
RECRUITING

Hamburg, 20095, Germany
Medyczne Centrum Hetmańska Piotr Leszczyński
RECRUITING

Poznan, Wielkopolska, 60-128, Poland
Mie University Hospital
RECRUITING

Tsu, Mie, Mie-ken, 514-8507, Japan
Nagoya City University Hospital
RECRUITING

Nagoya, Aichi-ken, 467-8602, Japan
Nanjing Medical University (NMU) - Jiangsu Province Hospital (First Affiliated Hospital)
RECRUITING

Nanjing, Jiangsu, 210029, China
National Hospital Organization Tokyo Medical Center
RECRUITING

Meguro-Ku, Tokyo, 152-8902, Japan
National University Corporation Tohoku University Tohoku University Hospital
RECRUITING

Sendai, Miyagi, 980-8574, Japan
Niagara Rheumatology Research Centre | Ontario, Canada
RECRUITING

Niagara Falls, Ontario, L2E 6A6, Canada
Nippon Life Hospital
RECRUITING

Nishi Ward, Osaka, 550-0006, Japan
North Georgia Rheumatology Group PC
RECRUITING

Lawrenceville, Georgia, 30046, United States
Northern Jiangsu People's Hospital
RECRUITING

Yangzhou, Jiangsu, 225007, China
Oxford University Hospitals NHS Trust
WITHDRAWN

Oxford, OX3 9RP, United Kingdom
Paramount Medical Research & Consulting, LLC
RECRUITING

Middleburg Heights, Ohio, 44130, United States
Peking Union Medical College Hospital
RECRUITING

Beijing, Beijing Municipality, 100730, China
Peking University Third Hospital
RECRUITING

Beijing, Beijing Municipality, 100191, China
Pratia | Centrum Medyczne Pratia Czestochowa - Czestochowa, Poland
RECRUITING

Częstochowa, Silesian Voivodeship, 42-217, Poland
Private Practice - Dr. Maren Sieburg
COMPLETED

Magdeburg, Saxony-Anhalt, 39104, Germany
RASF- Clinical Research Center
RECRUITING

Boca Raton, Florida, 33486-1390, United States
Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine
RECRUITING

Pudong New District, Shanghai Municipality, 200127, China
Reum-Medica s.c. Bozena Kowalewska, Marek Zawadzki
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 50-244, Poland
Rheumazentrum Ruhrgebiet
RECRUITING

Herne, 44649, Germany
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, NSW 2050, Australia
Sasebo Chuo Hospital
RECRUITING

Sasebo-shi, Nagasaki, 857-1195, Japan
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
RECRUITING

Shanghai, 200052, China
Shanxi Academy of Medical Sciences - Shanxi Bethune Hospital (Shanxi Dayi Hospital)
RECRUITING

Taiyuan, Shanxi, 030605, China
Shenzhen People's Hospital
RECRUITING

Shenzhen, Guangdong, 518020, China
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
RECRUITING

Chengdu, 610072, China
St Luke's Hospital - UK
RECRUITING

Bradford, West Yorkshire, BD5 0NA, United Kingdom
St. Luke's International Hospital
RECRUITING

Chuo-ku, Tokyo, 104-8560, Japan
Sun Yat-sen University - The Third Affiliated Hospital (Third Affiliated Hospital of Zhongshan Medical University)
RECRUITING

Guangzhou, 510630, China
Sunshine Coast University Private Hospital | Clinical Trials
RECRUITING

Sippy Downs, Queensland, QLD 4575, Australia
Swedish Rheumatology Research
RECRUITING

Seattle, Washington, 98122, United States
The 2nd Hospital of Xi'An Jiaotong University
RECRUITING

Xi'an, Shan'xi, 710004, China
The First Affiliated Hospital Of Bengbu Medical College
RECRUITING

Bengbu, Anhui, 233004, China
The First Affiliated Hospital of Henan University of Science and Technology
RECRUITING

Luoyang, Henan, 471000, China
The First Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, Jiangxi, 330006, China

Contact Email: •••••@•••••
The First Affiliated Hospital of Xiamen University
RECRUITING

Xiamen, Fujian, 361003, China
The First Peoples Hospital - Changzhou (The Third Affiliated Hospital of Suzhou University)
RECRUITING

Hangzhou, Jiangsu, 215005, China
The Princess Alexandra Hospital NHS Trust
RECRUITING

Harlow, CM20 1QX, United Kingdom
The Queen Elizabeth Hospital | Rheumatology Department
RECRUITING

Woodville South, South Australia, SA 5011, Australia
The Royal Wolverhampton NHS Trust
RECRUITING

Wolverhampton, WV10 0QP, United Kingdom
The Second Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, Jiangxi, 330008, China
Toho University Ohashi Medical Center
RECRUITING

Meguro-ku, Tokyo, 153-8515, Japan
Tohoku Medical and Pharmaceutical University Hospital
RECRUITING

Sendai, Miyagi, 983-8512, Japan
Tokyo Medical University Hospital
RECRUITING

Shinjuku-Ku, Tokyo, 160-0023, Japan
Union Hospital Tongji Medical College of Huazhong University of Science and Technology (HUST)
RECRUITING

Wuhan, Hubei, 430022, China
Universidade Federal de Uberlandia (UFU) - Campus Santa Monica - Centro de Pesquisa Clinica
RECRUITING

Uberlândia, Minas Gerais, 38405-320, Brazil
Universitatsklinikum Leipzig
RECRUITING

Leipzig, Saxony, 4103, Germany
University Health Network (UHN) - Toronto Western Hospital (TWH) - Centre for Prognosis Studies in the Rheumatic Diseases
WITHDRAWN

Toronto, Ontario, M5T 2S8, Canada
University Hospitals | UH Cleveland Medical Center - Department of Medicine - Rheumatology Division
RECRUITING

Cleveland, Ohio, 44106, United States
Wenzhou Medical University (WMU) - The First Affiliated Hospital
RECRUITING

Wenzhou, 325000, China
West China Hospital of Sichuan University
RECRUITING

Chengdu, Sichuan, 610041, China
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia
Xuanwu Hospital Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 100053, China
Zespol Poradni Specjalistycznych Reumed
RECRUITING

Lublin, 20-607, Poland
dermMedica Sp. z o.o.
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 51-503, Poland

More trials for these conditions

Other studies related to the condition(s) this trial covers.