New drug aims to protect kidneys in IgA nephropathy patients

NCT ID NCT06963827

Recruiting now Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 6 times

Summary

This Phase 3 trial tests whether mezagitamab, an injectable drug, can reduce protein in the urine and preserve kidney function in adults with IgA nephropathy, a condition where immune complexes damage the kidneys. About 347 participants will receive either mezagitamab or a placebo over two 1-year cycles, with regular check-ups. The main goal is to see if the drug lowers proteinuria at 36 weeks compared to placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mezagitamab (TAK-079) injections
What this could lead to: If it works, this could provide a new treatment option to slow kidney damage and delay kidney failure in people with IgA nephropathy.
What could go wrong: This is an early Phase 3 trial, so results are not yet proven. The drug may not significantly reduce proteinuria or preserve kidney function, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

IgA glomerulonephritis impaired renal function disease kidney disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY DISEASE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

4th Military Clinical hospital /Polyclinic SP ZOZ
RECRUITING

Wroclaw, 50-981, Poland
AOU Citta della Salute e della Scienza di Torino
RECRUITING

Torino, 10126, Italy
ASST degli Spedali Civili di Brescia - Spedali Civili di Brescia
RECRUITING

Brescia, 25124, Italy
Academic Medical Research Institute
RECRUITING

Los Angeles, California, 90022, United States
Affiliated Hospital of Nantong University
RECRUITING

Nantong, Jiangsu, 226001, China
Ajou University Hospital-Primary Research Location
RECRUITING

Suwon, Gyeonggido, 16499, South Korea
Akershus University Hospital
RECRUITING

Lorenskog, Akershus, 1478, Norway
Amsterdam UMC - Locatie AMC (Academisch Medisch Centrum)
RECRUITING

Amsterdam, North Holland, 1105 AZ, Netherlands
Az Ospedaliera Universitaria Policlinico G Martino
RECRUITING

Messina, 98122, Italy
Azienda Unita Sanitaria Locale Piacenza (AUSL) Ospedale "Guglielmo da Saliceto
RECRUITING

Piacenza, 29121, Italy
Beijing Tsinghua Changgung Hospital
RECRUITING

Changping, Beijing Municipality, 102218, China
Bioresearch Partners
RECRUITING

Miami, Florida, 33127, United States
Bioresearch Partners
RECRUITING

Pembroke Pines, Florida, 33029, United States
Birmingham Heartlands Hospital
RECRUITING

Birmingham, United Kingdom
Brookview Hills Research Associates, LLC
RECRUITING

Winston-Salem, North Carolina, 27103, United States
CARE Institute - Boise Kidney
RECRUITING

Boise, Idaho, 83706, United States
CHU Bordeaux, CHU Pellegrin
RECRUITING

Bordeaux, 33076, France
CHU Limoges Service de Nephrology
RECRUITING

Limoges, 87042, France
CHU de Nantes
RECRUITING

Nantes, 44093, France
CTR Oakwater, LLC
RECRUITING

Orlando, Florida, 32806, United States
Centre Hospitalier Universitaire de Montpellier (CHU Montpellier) - Hopital Lapeyronie
RECRUITING

Montpellier, 34090, France
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
RECRUITING

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1425AGC, Argentina
China Medical University Hospital
RECRUITING

Taichung, Taiwan
Clinica Privada Velez Sarsfield
RECRUITING

Córdoba, X5016, Argentina
Clinical Research Consultants a JCCT Company
RECRUITING

Kansas City, Missouri, 64111, United States
Core Research Group
RECRUITING

Milton, Queensland, Australia
DCR - El Paso
RECRUITING

El Paso, Texas, 79902, United States
DCR Columbus
RECRUITING

Columbus, Georgia, 31904, United States
DCR Edina
RECRUITING

Edina, Minnesota, 55435, United States
DCR Montgomery
RECRUITING

Montgomery, Alabama, 36117, United States
DCR San Antonio
RECRUITING

San Antonio, Texas, 78251, United States
Dallas Renal Group
RECRUITING

Dallas, Texas, 75230, United States
Dokkyo Medical University Saitama Medical Center
RECRUITING

Koshigaya-shi, Saitama, 343-8555, Japan
Eastern Health
RECRUITING

Box Hill, Victoria, 3128, Australia
Elixia MKC
RECRUITING

Pontiac, Michigan, 48341, United States
Elixia MNA
RECRUITING

City of Saint Peters, Missouri, 63376, United States
Erciyes University
RECRUITING

Kayseri, Melikgazi, 38039, Turkey (Türkiye)
First Faculty of Medicine Charles University
RECRUITING

Prague, Czechia
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
RECRUITING

Milan, 20100, Italy
Framingham Centro Medico
RECRUITING

Buenos Aires, La Plata, 1902, Argentina
Fujita Health University Hospital
RECRUITING

Toyoake-shi, Aichi-ken, 470-1192, Japan
Fukushima Medical University Hospital
RECRUITING

Fukushima, Fukushima, 960-1295, Japan
Fundacion Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
RECRUITING

Şahinbey, Gaziantep, 27310, Turkey (Türkiye)
Guangdong General Hospital
RECRUITING

Guangzhou, Guangdong, 510080, China
Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital
RECRUITING

London, Greater London, SE1 9RT, United Kingdom
Haukeland Universitetssjukehus
RECRUITING

Bergen, 5021, Norway
Hiroshima University Hospital
RECRUITING

Hiroshima, Hiroshima, 734-8551, Japan
Hokkaido University Hospital
RECRUITING

Sapporo, Hokkaido, 060-8648, Japan
Hospital Britanico de Buenos Aires
RECRUITING

Ciudad Autonoma Buenos Aires, 1280, Argentina
Hospital Henri Mondor
RECRUITING

Créteil, Paris, 94000, France
Hospital Sultan Idris Shah Serdang (Hospital Serdang)
RECRUITING

Kajang, Selangor, 43000, Malaysia
Hospital Taiping
RECRUITING

Taiping, Perak, 34000, Malaysia
Hospital Tengku Ampuan Afzan
RECRUITING

Kuantan, Pahang, 25100, Malaysia
Hospital Tenon
RECRUITING

Paris, 75020, France
Hospital Universitari Germans Trias i Pujol
RECRUITING

Badalona, Barcelona, 8915, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 8035, Spain
Hospital Universitario Virgen del Rocio - PPDS
RECRUITING

Seville, 41013, Spain
Hospital Universitario de Cruces
RECRUITING

Barakaldo, Bizkaia, 48903, Spain
Hospital del Mar
RECRUITING

Barcelona, 8003, Spain
Houston Methodist Research Institute - Department of Medicine
RECRUITING

Houston, Texas, 77030, United States
Hull University Teaching Hospitals NHS Trust
RECRUITING

Hull, United Kingdom
IRCCS Azienda Ospedaliero-Universitaria di Bologna
RECRUITING

Bologna, 40138, Italy
IRCCS Ospedale Policlinico San Martino
RECRUITING

Genoa, 16132, Italy
Indywidualna Specjalistyczna Praktyka Lekarska
RECRUITING

Lodz, Poland
Ingham Nephrology & Hypertension, P.C.
RECRUITING

Lansing, Michigan, 48911, United States
Istanbul Universitesi Cerrahpasa Tip Fakultesi
RECRUITING

Fatih, Istanbul, 34098, Turkey (Türkiye)
Istituto Maugeri IRCCS Pavia
RECRUITING

Pavia, 27100, Italy
Japan Community Health care Organization Sendai Hospital
RECRUITING

Sendai, Miyagi, 981-3281, Japan
Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital
RECRUITING

Nagoya, Aichi-ken, 466-8650, Japan
Johannes Kepler Universitat Linz, Universitatsklinik fur Innere 2
RECRUITING

Linz, 4040, Austria
Juntendo University Hospital
RECRUITING

Bunkyo-ku, Tokyo, 113-8431, Japan
Kahramanmaras Sutcu Imam Universitesi Tip Fakultesi Avsar Mah
RECRUITING

Kahramanmaraş, Onikisubat, 46040, Turkey (Türkiye)
Kaohsiung Medical University - Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Kasugai Municipal Hospital
RECRUITING

Kasugai-Shi, Aichi-ken, 486-8510, Japan
Kent & Canterbury Hospital, Canterbury
RECRUITING

Canterbury, CT1 3PA, United Kingdom
King's College Hospital
RECRUITING

London, WC2R 2LS, United Kingdom
Kocaeli Universitesi Tip Fakultesi Arastirma ve Uygulama Hastanesi
RECRUITING

Kocaeli, Turkey (Türkiye)
Kyushu University Hospital
RECRUITING

Fukuoka, Fukuoka, 812-8582, Japan
Lancashire Teaching Hospital NHS Foundation Trust
RECRUITING

Preston, PR29HT, United Kingdom
Leicester General Hospital
RECRUITING

Leicester, United Kingdom
Leids Universitair Medisch Center
RECRUITING

Leiden, 2333 ZA, Netherlands
London Health Sciences Centre
RECRUITING

London, Ontario, N6A5A5, Canada
Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-Kofuka
RECRUITING

Osaka, Osaka, 530-8480, Japan
Medizinische Universitat Wien (Medical University of Vienna - Austria)
RECRUITING

Vienna, 1090, Austria
Monash Heath - Monash University - Monash Medical Centre
RECRUITING

Clayton, Victoria, Australia
Nara Medical University Hospital
RECRUITING

Kashihara-shi, Nara, 634-8522, Japan
Nara Prefecture General Medical Center
RECRUITING

Nara, Nara, 630-8581, Japan
National Hospital Organization Chiba Medical Center Chibahigashi National Hospital
RECRUITING

Chiba, Chiba, 260-8712, Japan
National Taiwan University Hospital
RECRUITING

Zhongzheng, 100, Taiwan
National University Hospital
RECRUITING

Singapore, Singapore
Necmettin Erbakan University
RECRUITING

Konya, Selcuklu, 42280, Turkey (Türkiye)
Nemocnice AGEL Novy Jicin a.s
RECRUITING

Nový Jičín, Moravskoslezsk Kraj, 741 01, Czechia
Nephrology Associates of Houston PLLC
RECRUITING

Katy, Texas, 77450, United States
Northern General Hospital
RECRUITING

Sheffield, United Kingdom
Northwest Louisiana Nephrology
RECRUITING

Shreveport, Louisiana, 71101, United States
Nottingham University Hospitals NHS Trust - City Hospital
RECRUITING

Nottingham, United Kingdom
Nowy Szpital Sp Zo.o
RECRUITING

Gmina Świecie, 86-100, Poland
Oita University Hospital
RECRUITING

Yufu-shi, Oita Prefecture, 879-5593, Japan
Panoramic Health - Clinical Renal Associates, Ltd.
RECRUITING

Media, Pennsylvania, 19063, United States
Panoramic Health - Florida Kidney Physicians, LLC (Jacksonville)
RECRUITING

Jacksonville, Florida, 32250, United States
Panoramic Health - Florida Kidney Physicians, LLC (Melbourne)
RECRUITING

Melbourne, Florida, 32901, United States
Panoramic Health - Florida Kidney Physicians, LLC (Tampa)
RECRUITING

Riverview, Florida, 33578, United States
Panoramic Health - Kidney and Hypertension Center
RECRUITING

Cincinnati, Ohio, 45212, United States
Panoramic Health - Lake Michigan Nephrology, PLC
RECRUITING

Saint Joseph, Michigan, 49085, United States
Panoramic Health - Nephrology Associates, Inc.
RECRUITING

East Providence, Rhode Island, 02914, United States
Panoramic Health - RNA of Rockford, LLC dba Rockford Nephrology Associates
RECRUITING

Rockford, Illinois, 61107, United States
Panoramic Health - Southeast Kidney Associates
RECRUITING

East Point, Georgia, 30344, United States
Panoramic Health - Southwest Kidney Institute, PLC
RECRUITING

Surprise, Arizona, 85374, United States
Panoramic Health - Virginia Nephrology Group
RECRUITING

Arlington, Virginia, 22205, United States
Panoramic Health - West Coast Kidney Institute (Fremont)
RECRUITING

Fremont, California, 94538, United States
Peking University First Hospital
RECRUITING

Beijing, Beijing Municipality, 100034, China
Peking University Shenzhen Hospital
RECRUITING

Shenzhen, Guangdong, 518000, China
Provecta Research Network
RECRUITING

Houston, Texas, 77054, United States
Radboud Universitair Medisch Centrum
RECRUITING

Nijmegen, 6525 GA, Netherlands
Renal Medicine Associates - Frenova F1
RECRUITING

Albuquerque, New Mexico, 87109, United States
Renal Medicine Linkoping University/ Linkoping University Hospital
RECRUITING

Linköping, Sweden
Ruijin Hospital of Shanghai Jiaotong University School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, 200025, China
SCM Sp. z o.o.
RECRUITING

Krakow, 31-559, Poland
Semmelweis Egyetem - Belgyogyaszati es Onkologiai Klinika (I.sz. Belgyogyaszati Klinika)
RECRUITING

Budapest, 1083, Hungary
Seoul National University Boramae Medical Center
RECRUITING

Seoul, 7061, South Korea
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, Seongnam, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 3080, South Korea
Shandong University - Qilu Hospital
RECRUITING

Jinan, Shandong, 250012, China
Shanghai Jiao Tong University School of Medicine (SJTUSM) - Renji Hospital - Eastern Branch
RECRUITING

Shanghai, Shanghai Municipality, 200000, China
Sheldon M. Chumir Health Centre
RECRUITING

Calgary, Alberta, T2R 0X7, Canada
Shonan Kamakura General Hospital
RECRUITING

Kamakura-shi, Kanagawa, 247-8533, Japan
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
RECRUITING

Chengdu, Sichuan, 610072, China
Singapore General Hospital
RECRUITING

Singapore, 169608, Singapore
Sint Antonius ziekenhuis Utrecht/Nieuwegein
RECRUITING

Nieuwegein, 3435CM, Netherlands
South Florida Research Institute
RECRUITING

Lauderdale Lakes, Florida, 33313-1607, United States
South Western Sydney Local Health District - University of New South Wales - Liverpool Hospital
RECRUITING

Liverpool, New South Wales, Australia
St George's University Hospitals NHS Foundation Trust
RECRUITING

London, SW17 0QT, United Kingdom
Stavanger Universitetssjukehus - Helse Stavanger HF
RECRUITING

Stavanger, Norway
Sun Research Institute
RECRUITING

San Antonio, Texas, 78215, United States
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4G 3E8, Canada
Sunway Medical Centre (SMC)
RECRUITING

Subang Jaya, Selangor, 47500, Malaysia
Sykehuset I Vestfold
RECRUITING

Tønsberg, Vestfold, Norway
Sykehuset Ostfold
RECRUITING

Grålum, 1714, Norway
Taichung Veterans General Hospital
RECRUITING

Taichung, 40705, Taiwan
Taipei Medical University Shuang Ho Hospital
RECRUITING

New Taipei City, Taiwan
Tan Tock Seng Hospital
RECRUITING

Singapore, 308433, Singapore
The First Affiliated Hospital of Baotou Medical College
RECRUITING

Baotou, Inner Mongolia, 14010, China
The First Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of Ningbo University
RECRUITING

Ningbo, Zhejiang, 315010, China
The Second Affiliated Hospital, Zhejiang University, School of Medicine
RECRUITING

Hangzhou, Zhejiang, China
The Second People's Hospital of Yibin
RECRUITING

Yibin, Sichuan, 644099, China
The Third Xiangya Hospital of Central South University Yuelu District
RECRUITING

Changsha, Hunan, 410013, China
The University of Hong Kong - Department of Medicine
RECRUITING

Hong Kong, Hong Kong Island, Hong Kong
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tokyo Medical University Hospital
RECRUITING

Shinjuku-Ku, Tokyo, 160-0023, Japan
Toranomon Hospital Kajigaya
RECRUITING

Kawasaki-shi, Kanagawa, 213-8587, Japan
Turgut Ozal Medical Center
RECRUITING

Malatya, Battalgazi, 44280, Turkey (Türkiye)
UAB Nephrology Research Clinic at Paula Building
RECRUITING

Birmingham, Alabama, 35233-2110, United States
UMC Utrecht
RECRUITING

Utrecht, 3584 CX, Netherlands
Uniklinik RWTH Aachen
RECRUITING

Aachen, North Rhine-Westphalia, 52074, Germany
Universidad de Navarra - Clinica Universidad de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Universidad de Navarra - Clinica Universidad de Navarra
RECRUITING

Madrid, 28027, Spain
Universitaetsklinikum Jena
RECRUITING

Jena, Thuringia, 7747, Germany
Universitaetsmedizin der Johannes - Gutenberg Universitaet Mainz
RECRUITING

Mainz, 55131, Germany
Universitetssykehuset I Trondheim - St. Olavs Hospital - Nevroklinikken
RECRUITING

Trondheim, 7030, Norway
Universiti Kebangsaan Malaysia (UKM) - Medical Centre (Pusat Perubatan) (Hospital Canselor Tuanku Muhriz (HCTM))
RECRUITING

Kuala Lumpur, Kuala Lumpur, 56000, Malaysia
Universiti Malaya Medical Centre (UMMC)
RECRUITING

Kuala Lumpur, 50603, Malaysia
University Clinical Centre Maribor
RECRUITING

Maribor, Slovenia
University Hospital Zurich
RECRUITING

Zurich, 8091, Switzerland
University Medical Centre Ljubljana
RECRUITING

Ljubljana, 1000, Slovenia
University of California Irvine
RECRUITING

Orange, California, 92868-3201, United States
University of Yamanashi Hospital
RECRUITING

Chuo-shi, Yamanashi, 409-3898, Japan
Utah Kidney Research Institute
RECRUITING

Salt Lake City, Utah, 84115, United States
West China Hospital Sichuan University
RECRUITING

Chengdu, Sichuan, 610000, China
West Virginia University
RECRUITING

Morgantown, West Virginia, 26506, United States
Western Health Sunshine Hospital
RECRUITING

St Albans, Victoria, 3021, Australia
Wuxi People's Hospital
RECRUITING

Wuxi, Jiangsu, 214023, China
Yokohama City University Hospital
RECRUITING

Yokohama, Kanagawa, 236-0004, Japan
Zhongda Hospital Southeast University
RECRUITING

Nanjing, Jiangsu, 210009, China
Zhongshan Hospital Xiamen University
RECRUITING

Xiamen, Fujian, 361004, China

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