New drug TAK-928 takes on tough lung cancer in major trial

NCT ID NCT07217301

Recruiting now Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 3 times

Summary

This phase 3 trial tests TAK-928, a drug designed to activate T cells inside tumors, against standard chemotherapy (docetaxel) in 600 adults with advanced non-small cell lung cancer that has worsened after prior treatments. The goal is to see if TAK-928 can shrink tumors or help people live longer. Participants will receive treatment for up to 2 years, with regular monitoring.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TAK-928 (a drug that activates T cells in tumors) and docetaxel (standard chemotherapy)
What this could lead to: If successful, TAK-928 could offer a new treatment option for people with advanced lung cancer that has stopped responding to standard therapies.
What could go wrong: This is a phase 3 trial, but TAK-928 is still experimental. It may not work better than docetaxel, and could cause side effects like immune-related reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma non-small cell squamous lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IO-RESISTANT SQNSCLC

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Affiliated Cancer Hospital & Institute of Guangzhou Medical University
RECRUITING

Guangzhou, Guangdong, 510095, China
Anhui Provincial Cancer Hospital
NOT_YET_RECRUITING

Hefei, Anhui, 230088, China
Anhui Provincial Hospital
RECRUITING

Hefei, Anhui, 231501, China
Apex Research
RECRUITING

Fair Oaks, California, 95628, United States
BRCR Global
RECRUITING

Tamarac, Florida, 33322, United States
Beijing Cancer Hospital
RECRUITING

Beijing, Beijing Municipality, 100142, China
Cancer and Blood Specialty Clinic
RECRUITING

Los Alamitos, California, 90720, United States
Chongqing University Cancer Hospital
RECRUITING

Chongqing, Chongqing Municipality, 400030, China
D & H Cancer Research Center
RECRUITING

Margate, Florida, 33063, United States
Fujian Cancer Hospital
RECRUITING

Fuzhou, Fujian, 350014, China
Guangdong Provincial People's Hospital
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510080, China
Harbin Medical University Cancer Hospital
NOT_YET_RECRUITING

Harbin, Heilongjiang, 150081, China
Henan Cancer Hospital
RECRUITING

Zhengzhou, Henan, 450003, China
Henan Provincial People's Hospital
RECRUITING

Zhengzhou, Henan, 450003, China
Jiangsu Province Hospital
RECRUITING

Nanjing, Jiangsu, 210029, China
Liaoning Cancer Hospital
RECRUITING

Shenyang, Liaoning, 110042, China
Memorial Care
RECRUITING

Fountain Valley, California, 92708, United States
Nanjing Drum Tower Hospital
WITHDRAWN

Nanjing, Jiangsu, 210008, China
Nanjing Drum Tower Hospital
RECRUITING

Nanjing, Jiangsu, 210008, China
National Cancer Center
RECRUITING

Tokyo, 104-0045, Japan
Peking University People's Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100044, China
Shandong Cancer Hospital
RECRUITING

Jinan, Shandong, 250117, China
Shanghai Chest Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200030, China
Shanghai Pulmonary Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200433, China
Sichuan Cancer Hospital
RECRUITING

Chengdu, Sichuan, 610213, China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310016, China
St. Bernards Healthcare
RECRUITING

Jonesboro, Arkansas, 72401, United States
The Affiliated Hospital of Fujian Medical University
RECRUITING

Fuzhou, Fujian, 350004, China
The Affiliated Hospital of Southwest Medical University
RECRUITING

Luzhou, Sichuan, 646000, China
The Affiliated Hospital of Xuzhou Medical University
RECRUITING

Xuzhou, Jiangsu, 221006, China
The First Affiliated Hospital of Anhui Medical University
RECRUITING

Hefei, Anhui, 230022, China
The First Affiliated Hospital of Chongqing Medical University
RECRUITING

Chongqing, Chongqing Municipality, 400042, China
The First Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of Wenzhou Medical University
NOT_YET_RECRUITING

Wenzhou, Zhejiang, 325015, China
The First Affiliated Hospital of Xi'An Jiaotong University
RECRUITING

Xi'an, Shannxi, 710061, China
The First Affiliated Hospital of Xinxiang Medical University
RECRUITING

Xinxiang, Henan, 453100, China
The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITING

Zhengzhou, Henan, 450052, China
The First Affiliated Hospital, Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310003, China
The Fourth Hospital of Hebei University
RECRUITING

Shijiazhuang, Hebei, 050011, China
The Third Xiangya Hospital of Central South University
RECRUITING

Changsha, Hunan, 410205, China
The University of Texas M.D Anderson Cancer Center (MDACC)
RECRUITING

Houston, Texas, 77030, United States
Tianjin Medical University Cancer Institute & Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300000, China
Translation Research in Oncology- US, INC (TRIO-US)
RECRUITING

Torrance, California, 90505, United States
West China Hospital of Sichuan University
NOT_YET_RECRUITING

Chengdu, Sichuan, 611135, China
Yunnan Cancer Hospital
NOT_YET_RECRUITING

Kunming, Yunnan, 650118, China
Zhejiang Cancer Hospital
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310022, China

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