Takeda

This study is testing if a new version of an existing dengue vaccine works as well as the current version. About 500 healthy adults who have never had dengue will receive two shots, three months apart, of either the new or current formula. Researchers will check the participants'…

This study is testing whether adding the drug ixazomib to two other medications (lenalidomide and dexamethasone) can help control multiple myeloma longer in people who have already received initial treatment. About 160 adults with multiple myeloma who completed prior therapy will…

This study aims to monitor side effects in ovarian cancer patients taking the maintenance drug niraparib (Zedula). It will follow 354 participants for one year after they start treatment, tracking specific safety concerns like blood cell problems and high blood pressure. The stud…

This study is observing how well the drug brigatinib works for Chinese adults with a specific type of advanced lung cancer (ALK-positive NSCLC) in real-world medical settings. Researchers are not giving any new treatment; they are collecting data from about 200 patients who are a…

This study observes Chinese adults with multiple myeloma who switch from their initial treatment to a medication called ixazomib. Researchers will follow about 80 patients for up to 2 years to see how well the treatment works and what side effects occur. The goal is to understand…

This study is testing an experimental cell therapy called TAK-007 in adults whose B-cell non-Hodgkin lymphoma has returned or not responded to prior treatments. Participants receive chemotherapy followed by an infusion of specially engineered immune cells designed to find and att…

This study tested an oral medication called TAK-788 (mobocertinib) for adults with non-small cell lung cancer (NSCLC). The main goals were to find a safe and effective dose, understand how the body processes the drug, and see if it can shrink tumors, especially in people whose ca…

This study aims to check the long-term safety and effectiveness of an oral medication called TAK-279 for adults with moderate-to-severe plaque psoriasis. About 1,950 participants will take the drug for up to four years while doctors monitor for side effects and track skin improve…

This early-stage study is testing a new cell therapy called GDX012 for adults with acute myeloid leukemia (AML) that has returned or not responded to prior treatments. The main goals are to find out how safe the treatment is, what side effects patients experience, and to determin…

This study is testing an investigational drug called TAK-279 in adults with two severe and rare forms of psoriasis: generalized pustular psoriasis (GPP) and erythrodermic psoriasis (EP). All participants will receive the drug for up to 52 weeks. The main goal is to see how well i…

This study aims to learn about the long-term safety of a drug called fazirsiran for people with liver disease caused by Alpha-1 antitrypsin deficiency. It allows 31 participants from previous fazirsiran studies to continue receiving the drug every three months. The main goal is t…

This study is observing 50 patients in the UK who have hereditary angioedema (HAE) and are taking the drug lanadelumab as part of their normal care. The main goal is to compare how many HAE attacks patients experience in the year before starting the drug to the number they have i…

This program provided compassionate early access to the drug fruquintinib for adults with advanced colorectal cancer that had stopped responding to all standard treatments. Participants took oral capsules in repeating cycles. The goal was to control the cancer and extend life whe…

This study is testing a drug called TAK-771 to see if it can safely control symptoms in Japanese adults with two rare, long-term nerve disorders: CIDP and MMN. Participants, who must already be responding to a standard treatment, will receive TAK-771 for up to 45 months. The main…

This study is observing patients with moderate to severe Crohn's disease who are already being treated with the drug Entyvio (vedolizumab) in their regular doctor's care. The main goal is to collect long-term information on the drug's safety and how well it works to control the d…

This study aimed to see if a combination of immune-suppressing drugs could help young boys with Hunter syndrome better tolerate their main enzyme replacement therapy (ELAPRASE). The goal was to prevent their immune systems from developing antibodies that could block the treatment…

This study is testing whether a drug called ponatinib works better than the standard drug imatinib when both are given with lower-dose chemotherapy. It's for adults newly diagnosed with a fast-growing blood cancer called Philadelphia chromosome-positive acute lymphoblastic leukem…

This study aims to see if a new oral medication called zasocitinib is more effective than an existing drug, deucravacitinib, for people with moderate-to-severe plaque psoriasis. About 606 participants will take daily pills for 16 weeks, with researchers measuring how much their s…

This study continues monitoring the safety of two treatments (idursulfase-IT and Elaprase) for Hunter syndrome, a rare genetic disorder that causes cognitive impairment. It follows 6-8 children and adults from previous studies for nearly 5 years to track any side effects. The goa…

This study is testing an investigational drug called TAK-755 for adults with a rare and serious blood disorder called immune-mediated thrombotic thrombocytopenic purpura (iTTP). The main goal is to see if TAK-755 can help patients recover without needing the standard, intensive p…

This early-stage study is testing whether adding an experimental drug called TAK-079 to standard multiple myeloma treatments is safe and tolerable. The trial involves about 50 adults with newly diagnosed multiple myeloma who are not planning to get a stem cell transplant right aw…

This study is testing a new drug, brentuximab vedotin, added to standard chemotherapy for children with newly diagnosed, advanced Hodgkin lymphoma. The goal is to see if this combination is safe, effective, and what the best dose is for young patients. The trial enrolled about 59…

This study aims to collect real-world information about how well standard surgical procedures work for treating complex fistulas, which are painful abnormal connections between organs. Researchers will observe 750 patients with Crohn's disease-related or other complex fistulas wh…

This study is collecting information about how Brazilian patients with Crohn's disease or ulcerative colitis use the medication vedolizumab. Researchers are reviewing existing treatment records from about 1006 patients to understand how long they stay on treatment and what outcom…

This study aims to find out if the constipation medicine prucalopride is safe for use during pregnancy. Researchers will look at existing health insurance records of about 100 pregnant women with constipation, comparing those who took prucalopride to those who took other medicine…

This study aims to collect real-world information on the safety and effectiveness of the drug brentuximab vedotin for patients with CD30-positive lymphoma. It will follow about 1000 patients in China who are already receiving this treatment as part of their standard care. The goa…

This study is a long-term registry that aims to understand the safety and effectiveness of a hormone replacement drug (rhPTH[1-84]) for people with chronic hypoparathyroidism. It will follow over 1,300 adults and children who are already receiving treatment as part of their norma…

This study is observing how a new online tool, called CDPATH™, is used in regular doctor's offices. The tool estimates an adult patient's risk of developing Crohn's disease complications within the next three years. Researchers are enrolling about 200 recently diagnosed patients …

This study is analyzing existing data from a previous trial to learn how specific genetic changes in tumors relate to how long patients with advanced or returning colorectal cancer live and how long their cancer stays controlled. Researchers are looking at tumor tissue and blood …