Takeda

This study tested a new vaccine designed to protect against all four types of dengue fever. It involved about 30 healthy adults, some who had never had dengue and some who had. Researchers gave two shots three months apart to check the body's immune response and the vaccine's saf…

This study tested a new dengue fever vaccine in healthy Japanese children and adults. The goal was to see if the vaccine was safe and if it created an immune response that could protect against dengue. Participants received two shots, three months apart, and were followed for abo…

This large, completed study tested whether a new two-dose vaccine could prevent dengue fever in healthy children and teenagers. Over 20,000 participants aged 4 to 16 received either the real vaccine or a placebo shot. Researchers tracked the children for years to see how well the…

This study tested a new vaccine designed to prevent dengue fever. About 480 healthy children and adults in India received two shots of either the vaccine or a placebo (dummy shot) three months apart. The main goals were to check for side effects and see if the vaccine successfull…

This study tested brentuximab vedotin in Chinese adults with CD30-positive cutaneous T-cell lymphoma, a rare type of skin cancer. Ten participants received the drug through an IV every 3 weeks for up to 16 cycles. Researchers monitored how well the treatment worked and tracked si…

This study tested a drug called vedolizumab as a long-term treatment for children and teenagers with moderate to severe ulcerative colitis, a painful bowel disease. The goal was to see if regular infusions of the drug could help patients achieve and maintain remission, meaning th…

This study observed 155 people in Japan who were starting treatment with Lanadelumab for hereditary angioedema (HAE), a condition that causes severe swelling attacks. The main goal was to monitor for side effects and see if the treatment helped reduce the number of swelling episo…

This study monitored the long-term safety and effectiveness of the drug Entyvio (vedolizumab) in people with moderate to severe ulcerative colitis. It observed over 1,100 patients in Japan who were already receiving the drug as part of their regular care. The goal was to collect …

This study tested an investigational drug called TAK-625 in Japanese children with a rare, inherited liver disease called PFIC. The main goal was to see if the drug could reduce the severe, life-altering itching caused by the disease and lower harmful bile acid levels in the bloo…

This Phase 3 study tested whether an oral medication called TAK-861 could help people with Narcolepsy Type 1. About 105 participants took either the real pill or a placebo for 12 weeks. Researchers measured if it improved their ability to stay awake during the day and reduced sud…

This study tested whether adding a new drug called pevonedistat to a standard two-drug combination works better for adults newly diagnosed with acute myeloid leukemia (AML) who are too frail for intensive chemotherapy. About 164 participants worldwide were randomly assigned to re…

This study observed adults with moderate to severe Crohn's disease who started treatment with the drug vedolizumab in real-world clinic settings. Researchers followed 72 patients for 18 months to see if the treatment could lead to complete remission—meaning no symptoms, normal bl…

This study tested whether an experimental drug called TAK-101 could help adults with celiac disease who follow a gluten-free diet. Researchers wanted to see if TAK-101 could reduce symptoms and immune system reactions when participants were exposed to gluten. About 102 people rec…

This study monitored the safety of the cancer drug Cabometyx (cabozantinib) in 263 Japanese patients with advanced liver cancer that could not be removed by surgery. The main goal was to check for side effects and serious health problems over 12 months of treatment. Doctors also …

This large, completed study compared two different chemotherapy combinations for adults with newly diagnosed, advanced Hodgkin lymphoma. Over 1,300 patients were randomly assigned to receive either the standard treatment (ABVD) or a newer regimen (A+AVD) that included a targeted …

This study looked back at medical records to see how well a treatment called vonicog alfa worked for adults in the UK with von Willebrand disease (VWD), a common inherited bleeding disorder. Researchers reviewed data from 34 adults to understand how the treatment controlled bleed…

This study tested a new treatment called TAK-881 for people with primary immunodeficiency, a condition where the body's immune system doesn't work properly. It directly compared TAK-881 to an existing treatment, HYQVIA, in adults and teenagers, while also testing TAK-881 alone in…

This large, late-stage study tested whether a new oral drug, TAK-279, could clear or nearly clear the thick, scaly skin patches of moderate-to-severe plaque psoriasis. Over 1,100 participants were randomly assigned to receive TAK-279, a placebo (inactive pill), or an already-appr…

This study looked at how well two already-approved drugs work for hereditary angioedema (HAE) in real-world Chinese patients. Researchers reviewed the medical records of 115 patients to see how often attacks occurred while on the preventive drug lanadelumab and how quickly the re…

This study tested whether the drug brentuximab vedotin could shrink tumors in adults with anaplastic large cell lymphoma that had returned or didn't respond to previous chemotherapy. Fifty participants received the drug through an IV every three weeks. Researchers measured how ma…

This study tested how well and how safely a medication called leuprorelin works for children with central precocious puberty, a condition where puberty starts unusually early. About 80 children in China received an injection every 12 weeks for 6 months. The goal was to see if the…

This study tested whether the drug TAK-625 could help people with Alagille Syndrome, a rare genetic disorder that causes severe liver problems and intense itching. Seven Japanese participants, including infants and children, received the drug for up to 34 months to see if it safe…

This study tested three different starting doses of the drug ponatinib for patients with a specific type of chronic leukemia that had stopped responding to other standard treatments. The goal was to find the most effective and safest dose to control the disease. It involved 283 p…

This study tested a new drug, TAK-981, combined with an existing immunotherapy (pembrolizumab) for people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to find a safe dose and see if the combination could help shrink tumors. Ab…

This study compared two oral medications, brigatinib and alectinib, for people with advanced ALK-positive lung cancer whose cancer had worsened while taking their first targeted therapy. The trial involved 248 participants worldwide who were randomly assigned to receive one of th…

This early-stage study tested the safety and effects of mezagitamab, an experimental injection, in 17 people with IgA nephropathy, a kidney disease. Participants received weekly injections for 8 weeks, then every 2 weeks for 16 weeks, while continuing their standard medications. …

This early-stage study tested a new drug, TAK-676, combined with an existing immunotherapy (pembrolizumab) after a short course of radiation. It involved 34 adults with advanced lung cancer, triple-negative breast cancer, or head and neck cancer that had stopped responding to sta…

This study followed 15 Japanese patients with primary immunodeficiency diseases for 3 years to check long-term side effects of TAK-771 injections. Participants had already completed a previous study and received regular injections during clinic visits. The main goal was to monito…

This large, completed study tested if adding a new drug called pevonedistat to the standard treatment (azacitidine) could better control certain aggressive blood cancers. It involved 454 adults with high-risk myelodysplastic syndromes, chronic myelomonocytic leukemia, or low-blas…

This study tested a new oral drug called TAK-279 for people with moderate-to-severe plaque psoriasis. About 693 participants were randomly assigned to receive TAK-279, a placebo (inactive pill), or an existing approved drug for comparison. The main goal was to see how well TAK-27…

This study aimed to monitor the real-world safety and effectiveness of the drug VPRIV (velaglucerase alfa) in patients with Gaucher disease in Japan. It followed 63 patients, including those new to treatment and those switching from other therapies. The main goal was to track sid…

This study monitored children and teenagers in Japan who received Icatibant injections to treat sudden attacks of hereditary angioedema (HAE), a condition causing severe swelling. The main goal was to check for side effects and see how well the treatment worked to resolve these a…

This study monitored children aged 6 to 16 with high blood pressure who were taking the medication azilsartan. The main goals were to check for any side effects and see how well the drug controlled their blood pressure over 12 months. Doctors followed standard care practices whil…

This study aimed to understand the long-term safety of a medication called vedolizumab in children and teenagers with ulcerative colitis or Crohn's disease. It followed 59 young participants who had already responded to the drug in a previous trial, monitoring them for side effec…

This study monitored patients with ulcerative colitis or Crohn's disease in South Korea who were treated with vedolizumab (Kynteles injection) as part of their regular care. The main goals were to track side effects and see how many patients' symptoms improved while using this al…

This study tested a computer program designed to find people with Fabry disease earlier by scanning 10 years of past hospital records. The goal was to see if the AI algorithm could accurately flag patients who likely have this rare genetic condition. No new treatments were tested…

This study looked back at 7 years of UK medical records to understand how often kidney transplant patients get a difficult-to-treat virus called CMV. Researchers analyzed data from 330 patients to see what treatments were used, how well they worked, and what happened to patients'…

This study observed how doctors in Switzerland treat adults with Crohn's disease or ulcerative colitis using the medicine vedolizumab. Researchers watched whether patients received the drug as an infusion into a vein or as an injection under the skin, and tracked how long they st…

This study aimed to find out how often ADHD is missed in adults who already have another diagnosed mental health condition. Researchers assessed 224 adults across multiple countries who had a psychiatric disorder but no prior ADHD diagnosis. They checked for ADHD and then followe…

This study observed patients with Crohn's disease or ulcerative colitis in Poland who were receiving vedolizumab treatment, either by IV infusion or a newer under-the-skin injection. Researchers tracked which treatment method patients stayed on longer and why some switched or sto…

This was the first study to give the experimental drug TAK-004 to people. Its main goal was to check if the drug is safe and well-tolerated in healthy adults. Researchers also measured how the body processes the drug and if it affects heart rate or blood pressure. The study invol…

This study aimed to understand how children in China are treated for central precocious puberty (CPP), a condition where puberty starts unusually early. Researchers reviewed the past medical records of about 1,500 children diagnosed with CPP to see what treatments they received, …

This early-stage study aimed to check the safety and tolerability of a new immunoglobulin treatment called TAK-881 in healthy adults. The trial involved 64 healthy volunteers who received the drug under the skin to see how their bodies handled it. Researchers compared two differe…

This was a small, early-stage study to see how the body processes a new drug called TAK-123 and to check its safety. It involved 10 healthy Japanese men who received a single dose through an IV. The main goal was to gather basic information on how the drug moves through the body …

This study monitored the safety of Ninlaro (ixazomib) when used to treat multiple myeloma in real-world medical practice in China. Researchers followed 482 patients with multiple myeloma who were already taking or about to start Ninlaro treatment. The goal was to collect informat…

This early-stage study aimed to understand how the body processes a single dose of the experimental drug fazirsiran in people with varying levels of liver damage, compared to people with normal liver function. It involved 34 adults, some with liver scarring (cirrhosis) and some w…