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New hope for kids with rare liver disease: drug eases debilitating itch

NCT ID NCT05543187

Completed Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jan 30, 2026 · Last updated May 20, 2026 · Updated 9 times

Summary

This study tested a drug called TAK-625 in 5 Japanese children with Progressive Familial Intrahepatic Cholestasis (PFIC), a rare liver disease that causes severe, constant itching. The main goal was to see if the drug reduces itching and to check for side effects. Participants took the drug for up to 34 months, with frequent clinic visits to monitor their symptoms and drug levels.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Juntendo University Hospital

    Bunkyo-ku, Tokyo, Japan

  • Kyoto University Hospital

    Kyoto, Japan

  • Kyushu University Hospital

    Fukuoka, Japan

  • Osaka University Hospital

    Suita, Osaka, Japan

  • Saitama Prefectural Children's Medical Center

    Saitama, Japan

  • Tsuyama Chuo Hospital

    Tsuyama, Okayama-ken, Japan

  • University of Tsukuba Hospital

    Tsukuba, Ibaraki, Japan

  • Yokohamashi Tobu Hospital

    Yokohama, Kanagawa, Japan

Conditions

Explore the condition pages connected to this study.

PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS (PFIC)