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Real-World surgery study aims to improve fistula care

NCT ID NCT04940611

Completed Knowledge-focused Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tracked 646 people with complex fistulas (abnormal tunnels) caused by Crohn's disease or other conditions. Researchers observed the standard surgical treatments patients received at their clinics and recorded outcomes like fistula closure and complications. The goal is to gather real-world evidence on what works best in everyday practice.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors understand which surgical approaches work best for complex fistulas, potentially improving future treatment guidelines.
What could go wrong
This is an observational study, not a controlled trial, so it cannot prove which surgery is best. Results may vary across clinics and patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anal fistula Crohn disease Fistula Rectovaginal Fistula

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMPLEX CRYPTOGLANDULAR FISTULA COMPLEX PERIANAL FISTULA CROHNS DISEASE FISTULA RECTOVAGINAL FISTULA

Contacts and locations

Locations

  • AKH - Medizinische Universitat Wien

    Vienna, 1090, Austria

  • AZ Delta

    Roeselare, 8800, Belgium

  • Amsterdam UMC, Locatie AMC

    Amsterdam, 1105 AZ, Netherlands

  • Baptist MD Anderson Cancer Center

    Jacksonville, Florida, 32207, United States

  • Baylor Research Institute

    Dallas, Texas, 75204, United States

  • Broomfield Hospital

    Chelmsford, Essex, CM1 7ET, United Kingdom

  • CHRU Hopital Claude Huriez

    Lille, Nord, 59037, France

  • CHU de Rennes - Hopital Pontchaillou

    Rennes, Ille Et Vilaine, 35000, France

  • CHU de Rouen - Hopital Charles Nicolle

    Rouen, Seine Maritime, 76031, France

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Clinique CHC MontLegia

    Liège, 4000, Belgium

  • Cliniques Universitaires Saint-Luc

    Brussels, 1200, Belgium

  • Colon & Rectal Clinic

    Houston, Texas, 77030, United States

  • Fakultni nemocnice Brno

    Brno, 625 00, Czechia

  • Fakultni nemocnice Olomouc

    Olomouc, 779 00, Czechia

  • Fakultni nemocnice u sv. Anny v Brne

    Brno, 656 91, Czechia

  • Fondation Maison Sante Bagatelle

    Talence, Gironde, 33400, France

  • GI Alliance - Baton Rouge

    Baton Rouge, Louisiana, 70809, United States

  • Groupe Hospitalier Diaconesses - Hopital De La Croix Saint Simon

    Paris, 75012, France

  • Hopital Saint Joseph - Paris

    Paris, 75014, France

  • Hospices Civils de Lyon (HCL) - Centre Hospitalier Lyon-Sud

    Pierre-Bénite, Bouches-du-Rhone, 69310, France

  • Istituto Clinico Humanitas

    Rozzano, Milano, 20089, Italy

  • Jessa Ziekenhuis Hospital

    Hasselt, 3500, Belgium

  • Lenox Hill Hospital PRIME

    New York, New York, 10075, United States

  • NH Hospital a.s.Nemocnice Horovice

    Hořovice, 268 31, Czechia

  • Nottingham University Hospital

    Nottingham, Nottinghamshire, NG7 2UH, United Kingdom

  • Penn Medicine PA

    Philadelphia, Pennsylvania, 19104, United States

  • Premier Health

    Dayton, Ohio, 45409, United States

  • Rambam Health Care Center

    Haifa, 3109601, Israel

  • Royal Victoria Infirmary.

    Newcastle upon Tyne, Tyne & Wear, NE1 4LP, United Kingdom

  • Shamir Medical Center (Assaf Harofeh)

    Be’er Ya‘aqov, 7033001, Israel

  • St. Pauls Hospital

    Vancouver, British Columbia, V6Z 1Y6, Canada

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 64239, Israel

  • Temple University Hospital

    Philadelphia, Pennsylvania, 19140, United States

  • UMC Utrecht

    Utrecht, 3508 GA, Netherlands

  • UNC Hospitals

    Chapel Hill, North Carolina, 27599, United States

  • UZ Antwerpen

    Antwerp, 2650, Belgium

  • University of Kansas Medical Center Research Institute, Inc.

    Kansas City, Kansas, 66160, United States

  • University of South Florida - PARENT

    Tampa, Florida, 33612, United States

  • Vanderbilt University Medical Center- GI Endoscopy Lab

    Nashville, Tennessee, 37212, United States

  • Wolfson Medical Center

    Holon, 58100, Israel

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