Anal fistula

This pilot study tests two stem cell treatments for anal fistulas in people with Crohn's disease. One uses donor stem cells (Alofisel), the other uses stem cells from the patient's own fat. The goal is to see which works better at closing the fistula. The study plans to enroll 20…

This study is testing a new surgical stapler, called the Signia circular stapler, in people having left-sided colon, sigmoid, or rectal surgery. The goal is to see if it lowers the chance of a leak where the colon is reconnected. About 137 adults will take part, and the main focu…

This study is testing a device called BioHealx, a bioabsorbable implant that is placed in the anal fistula to close the internal opening and allow healing. Researchers will enroll 50 adults with a single anal fistula that has failed previous treatment. The goal is to see if the d…

This study compares two surgical methods for treating high anal fistulas, a condition where an infected tunnel forms between the anal canal and skin. The trial will enroll 64 adults and measure which surgery leads to better healing and fewer complications. The goal is to find a s…

This study compares two surgical techniques—IFOC and LIFT—for treating high anal fistula, a tunnel that forms between the anal canal and skin. About 66 adults with this condition will be randomly assigned to one of the two procedures. The main goal is to see which surgery leads t…

This study tests a new hydrogel (ECMT-100) to treat anorectal fistulas—abnormal tunnels between the anal canal and skin. Ten adults with a single high fistula will receive the gel to see if it safely closes the external openings and improves symptoms like incontinence and quality…

This study compares two surgical methods for treating a complex type of anal fistula (an abnormal tunnel from the anus to the skin). The goal is to see which surgery has a lower chance of the fistula coming back and which has a lower risk of causing bowel control problems. About …

This early-phase trial tests whether injecting special cells from human umbilical veins (E-CEL UVEC) can safely help heal simple anal fistulas after surgery. The study involves 39 adults who are already scheduled for fistulotomy. Researchers will monitor for side effects over two…

This study follows 275 Crohn's disease patients in Japan who receive darvadstrocel, a stem cell injection, for complex anal fistulas. Researchers will monitor side effects and whether fistulas close over 36 months. The goal is to see if this treatment is safe and works in real-wo…

This study tests a new treatment called RD2 Ver.02, a gel made from a patient's own blood, for healing anal fistulas. About 110 adults with certain types of fistulas will receive either the gel or a saltwater placebo after the fistula is cleaned and stitched closed. The main goal…

This study looks at how long a soft silicone loop (seton) should remain in the fistula tract to treat anal fistula in children aged 0-18. The loop is placed under anesthesia to drain infection and allow healing without cutting the muscle. The goal is to find the best timing to pr…

This trial tests a less invasive surgical technique for complex perianal fistula, a painful condition. The new approach uses lower power and causes less tissue damage. Researchers will compare healing rates, pain, and quality of life in 40 adults over six months.

This study looks at whether wrist-ankle acupuncture can reduce pain after perianal surgery. About 58 adults with moderate to severe pain will receive this acupuncture along with standard care. Researchers will measure pain relief and how often extra pain medicine is needed.

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study looks at how chronic perianal conditions like fistulas and abscesses impact a person's sexual health and body image—something often overlooked by doctors. Researchers will survey 60 adults using questionnaires to measure these effects and identify gaps in communication…

This study follows 100 adults who need surgery for an anal fistula. Researchers will track healing, recurrence, and quality of life for one year after the procedure. The goal is to see which surgical methods work best in real-world settings. No new treatments are being tested—onl…

This observational study follows 800 adults who receive Myriad™ during soft tissue reconstruction for wounds like abdominal dehiscence, pressure injuries, or anal fistulas. Researchers track healing time, complications, and side effects to understand how well the material works i…