Anal fistula
MONDO:0000754An intestinal disorder characterized by an opening in the anal canal to the perianal skin. In the vast majority of cases there is a history of perianal abscess.
Also known as: anal fistula, anal fistula (disease), anorectal fistula
51 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
-
Can stem cell vesicles heal Crohn's fistulas?
Disease control TerminatedThis early-phase trial tests whether ExoFlo, a product made from extracellular vesicles derived from donor bone marrow stem cells, can safely treat perianal fistulas in people with Crohn's disease. The study enrolls adults aged 18-75 who have had Crohn's for at least six months a…
Phase: PHASE1, PHASE2 • Sponsor: Direct Biologics, LLC • Aim: Disease control
Last updated Aug 13, 2026 00:00 UTC
-
Stem cell shot aims to heal painful Crohn's fistulas
Disease control TerminatedThis early-stage study tested whether injecting donor stem cells directly into fistulas (abnormal tunnels) could help people with Crohn's disease. The trial planned to enroll 25 adults but was terminated early. The goal was to check safety and see if the treatment could lead to c…
Phase: PHASE1, PHASE2 • Sponsor: Anthony Lembo • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
-
Stem cell therapy for Crohn's fistulas: safety check ends early
Disease control TerminatedThis study tested the long-term safety and effectiveness of a stem cell treatment called darvadstrocel (Alofisel) for people with Crohn's disease and complex anal fistulas. Researchers planned to give one injection of the stem cells and follow 53 participants over several visits,…
Phase: PHASE4 • Sponsor: Takeda • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
-
Experimental injection aims to heal painful fistulas in kids with Crohn's
Disease control TerminatedThis study tested a treatment called darvadstrocel for children with Crohn's disease who have complex perianal fistulas (abnormal tunnels near the anus). Seven participants received an injection of the treatment near the fistula after a cleaning procedure. The goal was to see if …
Phase: PHASE3 • Sponsor: Takeda • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
-
Which seton works best for anal fistulas? trial cut short
Symptom relief TerminatedThis study compared two types of drainage setons—Ethibond suture and vessel loop—for treating complex anal fistulas. The goal was to see which material drains infection better, lasts longer, and improves quality of life. However, the trial was terminated early after enrolling onl…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Symptom relief
Last updated Jun 27, 2026 07:55 UTC