Experimental injection aims to heal painful fistulas in kids with Crohn's
NCT ID NCT04701411
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a treatment called darvadstrocel for children with Crohn's disease who have complex perianal fistulas (abnormal tunnels near the anus). Seven participants received an injection of the treatment near the fistula after a cleaning procedure. The goal was to see if the fistulas would close and stay closed for up to a year. However, the study was stopped early, so we have very little data on how well it works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
darvadstrocel (a cell therapy injection near the fistula)
What this could lead to
If it works, this could offer a new way to close complex fistulas in children with Crohn's disease, potentially reducing pain and infections.
What could go wrong
The trial was terminated early with only 7 participants, so results are very limited. It is unclear if the treatment is effective or safe in children.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CROHN'S DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Amsterdam UMC, Locatie AMC
Amsterdam, 1105 AZ, Netherlands
-
Erasmus Medisch Centrum
Rotterdam, 3000 CA, Netherlands
-
Gabinet Lekarski Bartosz Korczowski
Rzeszów, 35-302, Poland
-
Hadassah University Hospital-Mt. Scopus
Jerusalem, 9124001, Israel
-
Hospital Infantil Universitario Nino Jesus
Madrid, 28009, Spain
-
Hospital Materno-Infantil de Malaga
Málaga, 29011, Spain
-
Hospital Sant Joan de Deu
Barcelona, 8950, Spain
-
Hospital Universitari Germans Trias i Pujol
Badalona, 8916, Spain
-
Hospital Universitari Vall d'Hebron
Barcelona, 8035, Spain
-
Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040, Spain
-
Instytut "Pomnik - Centrum Zdrowia Dziecka"
Warsaw, 04-730, Poland
-
Jichi Medical University Hospital
Shimotsuke-shi, 329-0498, Japan
-
Juntendo University Hospital
Bunkyō City, 113-8431, Japan
-
Medical Hospital, Tokyo Medical and Dental University
Bunkyō City, 113-8519, Japan
-
Mie University Hospital
Tsu, 514-8507, Japan
-
Miyagi Children's Hospital
Sendai, 989-3126, Japan
-
Rambam Health Care Campus
Haifa, 3109601, Israel
-
Schneider Children's Medical Center
Petah Tikva, 4920235, Israel
-
Shaare Zedek Medical Center
Jerusalem, 91031, Israel
-
Shamir Medical Center (Assaf Harofeh)
Be’er Ya‘aqov, 7033001, Israel
-
Universitair Medisch Centrum Groningen (UMCG)
Groningen, 9713 GZ, Netherlands
-
Uniwersytecki Szpital Dzieciecy w Krakowie
Krakow, 30-663, Poland