New stapler aims to reduce leaks after colon surgery

NCT ID NCT07351071

Recruiting now Disease control Sponsor: Medtronic - MITG Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing a new surgical stapler, called the Signia circular stapler, in people having left-sided colon, sigmoid, or rectal surgery. The goal is to see if it lowers the chance of a leak where the colon is reconnected. About 137 adults will take part, and the main focus is safety and how well the stapler works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Signia circular stapler (a surgical device used to reconnect the colon after resection)
What this could lead to: If successful, this could show that the Signia stapler is safe and effective for left-sided colon surgery, potentially reducing the risk of anastomotic leaks.
What could go wrong: This is a single-arm, post-market study with no comparison group, so results may not prove superiority over other staplers. The main risk is still anastomotic leakage, which can be serious.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Anastomotic Leak colonic disorder Digestive System Diseases digestive system disorder intestinal disorder Postoperative Complications rectal disorder rectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANASTOMOTIC COMPLICATION ANASTOMOTIC LEAK ANASTOMOTIC LEAKS COLONIC DISEASES COLORECTAL ANASTOMOSIS DIGESTIVE SYSTEM DISEASES GASTROINTESTINAL DISEASES INTESTINAL DISEASES LEFT-SIDED COLON RESECTION POSTOPERATIVE COMPLICATIONS RECTAL DISEASES

Contacts and locations

Locations

Duke University
RECRUITING

Durham, North Carolina, 27705, United States
Lankenau Institute for Medical Research
RECRUITING

Wynnewood, Pennsylvania, 19096, United States
Massachusetts General Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
NOT_YET_RECRUITING

Rochester, Minnesota, 55902, United States
SSM Health St. Mary's Hospital - Madison
NOT_YET_RECRUITING

Madison, Wisconsin, 53715, United States
The Ohio State University Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
The University of South Florida
RECRUITING

Tampa, Florida, 33620, United States
University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77030, United States
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

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