GASTROINTESTINAL DISEASES

This study is testing a new surgical stapler, called the Signia circular stapler, in people having left-sided colon, sigmoid, or rectal surgery. The goal is to see if it lowers the chance of a leak where the colon is reconnected. About 137 adults will take part, and the main focu…

This Phase 3 trial is testing whether a new medicine called PF-08634404, combined with standard chemotherapy, works better than the current treatment Avastin plus chemo for people whose colorectal cancer has spread. About 800 participants who have not had prior treatment for meta…

This first-in-human study tests an experimental oral drug called IDRX-42 in 278 adults with advanced gastrointestinal stromal tumors (GIST) that have spread or cannot be removed by surgery. The main goals are to check safety, find the right dose, and see if the drug can shrink tu…

This study tests whether fecal microbiota transplantation (FMT) can help children and young adults with autism who also have stomach issues. FMT involves transferring healthy donor stool into the patient's gut via colonoscopy. Researchers will track changes in gut and autism symp…

This study is testing a new, ultra-thin endoscope that goes through the nose without sedation, instead of the usual mouth-and-sedation approach. Researchers want to see if it improves patient experience and lowers costs for people in bariatric care. About 100 adults will try the …

This study tests whether a daily dose of Skal Pro—a mix of a friendly bacteria (Lactobacillus plantarum 299v) and a prebiotic fiber—can reduce IBS symptoms like belly pain, bloating, and irregular bowel movements. Sixty adults with IBS will receive either the supplement or a dumm…

This study tests whether using virtual reality (VR) can reduce symptoms of non-cardiac chest pain, which is chest pain not caused by the heart. Ten adults with this condition will try VR sessions, and researchers will measure changes in pain, anxiety, and quality of life. The goa…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study looks at how bacteria in the gut (the microbiome) influence healing of leaks in the esophagus or stomach. Researchers will collect tissue and fluid samples from 50 adults during routine procedures to analyze microbial changes and the body's response. The goal is to und…