GASTROINTESTINAL DISEASES

This study is testing whether a new drug, PF-08634404, works better than the current standard treatment for people whose colorectal cancer has spread. About 800 adults who haven't yet received treatment for their advanced cancer will be randomly assigned to get either the new dru…

This is the first-ever study in people for an experimental pill called IDRX-42. It aims to find a safe dose and see if it can help control advanced gastrointestinal stromal tumors (GIST) that have spread or cannot be removed by surgery. The study will enroll adults whose cancer h…

This early-stage study is testing whether transferring healthy gut bacteria from a donor (a fecal microbiota transplant) can improve both gastrointestinal problems and core autism symptoms. It will involve 60 participants aged 7-30 with autism and gut issues. Researchers aim to s…

This study is testing a specific surgical stapler to see how safe and effective it is for reconnecting the bowel after surgery on the left side of the colon or rectum. It will follow 137 patients to measure how often a dangerous complication called an 'anastomotic leak' happens a…

This study is testing a new, very thin endoscope that goes through the nose instead of the mouth and doesn't require sedation. It aims to see if this method is a good, cheaper, and faster way to check for stomach and esophagus problems in people enrolled in a weight management pr…

This small Mayo Clinic study is testing whether using virtual reality (VR) can help improve symptoms for people with non-cardiac chest pain. Researchers want to see if the VR treatment is practical and acceptable to patients before planning a larger trial. They will also check if…

This study aims to collect medical data and samples from people being treated for digestive problems. Researchers will gather this information during participants' regular doctor visits to use in future studies. The goal is to build a resource that helps scientists better underst…

This study aims to understand how the community of bacteria in the gut changes when a leak occurs after stomach or esophagus surgery. Researchers will collect fluid and tissue samples from 50 adult patients who have developed such leaks. By comparing these samples, they hope to l…