New hope for colorectal cancer: experimental drug faces off against standard care

NCT ID NCT07222800

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 24 times

Summary

This study tests a new medicine, PF-08634404, combined with standard chemotherapy for people whose colorectal cancer has spread. About 800 adults will be randomly assigned to receive either the new drug or an approved drug (bevacizumab), both with chemo. The goal is to see which combination works better at slowing cancer growth and extending life.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AMG Oncology & Hematology -Yankton
RECRUITING

Yankton, South Dakota, 57078, United States
AZ Sint-Lucas
NOT_YET_RECRUITING

Ghent, 9000, Belgium
Aichi Cancer Center Hospital
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Asklepios Altona
NOT_YET_RECRUITING

Hamburg, 22763, Germany
Avera Cancer Institute
RECRUITING

Sioux Falls, South Dakota, 57105, United States
Avera Cancer Institute- Aberdeen
RECRUITING

Aberdeen, South Dakota, 57401, United States
Avera Cancer Institute- Marshall
RECRUITING

Marshall, Minnesota, 56258, United States
Avera Cancer Institute- Mitchell
RECRUITING

Mitchell, South Dakota, 57301, United States
Avera Cancer Institute- Pierre
RECRUITING

Pierre, South Dakota, 57501, United States
BRCR Global - Coral Springs
RECRUITING

Coral Springs, Florida, 33065, United States
CETIR
NOT_YET_RECRUITING

Barcelona, 08029, Spain
CHU Brest, Hopital La Cavale Blanche
NOT_YET_RECRUITING

Brest, 29200, France
Cancer Care Centers of Brevard, Inc.
RECRUITING

Melbourne, Florida, 32935, United States
Cancer Care Centers of Brevard, Inc.
RECRUITING

Palm Bay, Florida, 32909, United States
Cancer Care Centers of Brevard, Inc.
RECRUITING

Rockledge, Florida, 32955, United States
Cancer Partners of Nebraska
RECRUITING

Lincoln, Nebraska, 68516, United States
Centro de Oncologia - CEON+ - Unidade São Caetano do Sul
RECRUITING

São Caetano do Sul, São Paulo, 09541-270, Brazil
Chang Gung Medical Foundation-Linkou Branch
NOT_YET_RECRUITING

Taoyuan District, 333, Taiwan
Chang Gung Memorial Hospital at Kaohsiung
NOT_YET_RECRUITING

Kaohsiung City, 83301, Taiwan
Chiba cancer center
RECRUITING

Chiba, Chiba, 260-8717, Japan
Clínica Radiológica HLA Mario Gallegos
NOT_YET_RECRUITING

Málaga, Andalusia, 29016, Spain
DRK Kliniken Berlin - Köpenick
NOT_YET_RECRUITING

Berlin, 12559, Germany
Florida Cancer Specialists
RECRUITING

Bonita Springs, Florida, 34135, United States
Florida Cancer Specialists
RECRUITING

Bradenton, Florida, 34211, United States
Florida Cancer Specialists
RECRUITING

Cape Coral, Florida, 33909, United States
Florida Cancer Specialists
RECRUITING

Fort Myers, Florida, 33905, United States
Florida Cancer Specialists
RECRUITING

Fort Myers, Florida, 33908, United States
Florida Cancer Specialists
RECRUITING

N. Venice, Florida, 34275, United States
Florida Cancer Specialists
RECRUITING

Naples, Florida, 34102, United States
Florida Cancer Specialists
RECRUITING

Port Charlotte, Florida, 33980, United States
Florida Cancer Specialists
RECRUITING

Sarasota, Florida, 34236, United States
Gemeinschaftspraxis Hämatologie - Onkologie Freiberg-Richter, Jacobasch, Illmer, Wolf
NOT_YET_RECRUITING

Dresden, 01307, Germany
Grand Hôpital de Charleroi
NOT_YET_RECRUITING

Charleroi, Hainaut, 6060, Belgium
Hadassah Medical Center
NOT_YET_RECRUITING

Jerusalem, Jerusalem, 9112001, Israel
Hematology Oncology Associates of Rockland
RECRUITING

Nyack, New York, 10960, United States
Hematology-Oncology Associates of Central New York, PC
RECRUITING

Camillus, New York, 13031, United States
Hematology-Oncology Associates of Central New York, PC
RECRUITING

East Syracuse, New York, 13057, United States
Henri Mondor Hospital
NOT_YET_RECRUITING

Créteil, Île-de-France Region, 94000, France
Henry-Joyce Cancer Clinic
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
Highlands Oncology Group
RECRUITING

Fayetteville, Arkansas, 72703, United States
Highlands Oncology Group
RECRUITING

Rogers, Arkansas, 72758, United States
Highlands Oncology Group
RECRUITING

Springdale, Arkansas, 72762, United States
Hope and Healing Cancer Services
RECRUITING

Hinsdale, Illinois, 60521, United States
Hope and Healing Cancer Services
RECRUITING

New Lenox, Illinois, 60451, United States
Hospital Clinic de Barcelona
NOT_YET_RECRUITING

Barcelona, 08036, Spain
Hospital Jerez de la Frontera
NOT_YET_RECRUITING

Jerez de la Frontera, Cádiz, 11407, Spain
Hospital Regional Universitario de Malaga (Hospital Civil)
NOT_YET_RECRUITING

Málaga, 29011, Spain
Hospital Universitari Vall d'Hebron
NOT_YET_RECRUITING

Barcelona, Barcelona [barcelona], 08035, Spain
Hospital Universitario Reina Sofia
NOT_YET_RECRUITING

Córdoba, 14004, Spain
Hôpital Européen Georges Pompidou
NOT_YET_RECRUITING

Paris, 75015, France
Icon Cancer Centre Hobart
RECRUITING

Hobart, Tasmania, 7000, Australia
Icon Cancer Centre Wesley
RECRUITING

Auchenflower, Queensland, 4066, Australia
Illinois Cancer Care
RECRUITING

Peoria, Illinois, 61615, United States
Illinois Cancer Specialists
RECRUITING

Arlington Heights, Illinois, 60005, United States
Illinois Cancer Specialists
RECRUITING

Chicago, Illinois, 60631, United States
Illinois Cancer Specialists
RECRUITING

Niles, Illinois, 60714, United States
Illinois CancerCare - Bloomington
RECRUITING

Bloomington, Illinois, 61704, United States
Illinois CancerCare - Galesburg
RECRUITING

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Ottawa-Fox River Cancer Center
RECRUITING

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
RECRUITING

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peru - Valley Regional Cancer Center
RECRUITING

Peru, Illinois, 61354, United States
Illinois CancerCare-Washington
RECRUITING

Washington, Illinois, 61571, United States
Institut Gustave Roussy
NOT_YET_RECRUITING

Villejuif, 94800, France
Intermountain Health Cancer Center Saint Joseph
NOT_YET_RECRUITING

Denver, Colorado, 80218, United States
Intermountain Health Saint Joseph Hospital
NOT_YET_RECRUITING

Denver, Colorado, 80218, United States
Intermountain Health Saint Joseph Hospital - Research Office
NOT_YET_RECRUITING

Denver, Colorado, 80218, United States
Ironwood Cancer & Research Centers
RECRUITING

Chandler, Arizona, 85224, United States
Ironwood Cancer & Research Centers
RECRUITING

Gilbert, Arizona, 85297, United States
Ironwood Cancer & Research Centers
RECRUITING

Glendale, Arizona, 85306, United States
Ironwood Cancer & Research Centers
RECRUITING

Goodyear, Arizona, 85395, United States
Ironwood Cancer & Research Centers
RECRUITING

Mesa, Arizona, 85202, United States
Ironwood Cancer & Research Centers
RECRUITING

Mesa, Arizona, 85206, United States
Ironwood Cancer & Research Centers
RECRUITING

Phoenix, Arizona, 85028, United States
Ironwood Cancer & Research Centers
RECRUITING

Scottsdale, Arizona, 85260, United States
Kaiser Permanente Interstate Medical Office Central
NOT_YET_RECRUITING

Portland, Oregon, 97227, United States
Kaiser Permanente Sunnyside Medical Center
NOT_YET_RECRUITING

Clackamas, Oregon, 97015, United States
Kaiser Permanente Westside Medical Center
NOT_YET_RECRUITING

Hillsboro, Oregon, 97124, United States
Kanagawa cancer center
RECRUITING

Yokohama, Kanagawa, 241-8515, Japan
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Kyushu University Hospital
RECRUITING

Fukuoka, 812-8582, Japan
McGill University Health Centre
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Mid Florida Hematology and Oncology Center
RECRUITING

Orange City, Florida, 32763, United States
National Cheng Kung University Hospital
NOT_YET_RECRUITING

Tainan, 704, Taiwan
National Hospital Organization Osaka Medical Center
RECRUITING

Osaka, 540-0006, Japan
National Taiwan University Hospital
NOT_YET_RECRUITING

Taipei, 10002, Taiwan
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
RECRUITING

Blacksburg, Virginia, 24060, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
RECRUITING

Low Moor, Virginia, 24457, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
RECRUITING

Roanoke, Virginia, 24014, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
RECRUITING

Salem, Virginia, 24153, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
RECRUITING

Wytheville, Virginia, 24382, United States
Oncology Associates of Oregon, P.C.
RECRUITING

Albany, Oregon, 97321, United States
Oncology Associates of Oregon, P.C.
RECRUITING

Corvallis, Oregon, 97330, United States
Oncology Associates of Oregon, P.C.
RECRUITING

Eugene, Oregon, 97401, United States
Oncology Associates of Oregon, P.C.
RECRUITING

Springfield, Oregon, 97477, United States
Oncology Consultants P.A.
RECRUITING

Houston, Texas, 77008, United States
Oncology Consultants P.A.
RECRUITING

Houston, Texas, 77024, United States
Oncology Consultants P.A.
RECRUITING

Houston, Texas, 77030, United States
Oncology Hematology Care - Eastgate
RECRUITING

Cincinnati, Ohio, 45245, United States
Oncology Hematology Care Clinical Trials, LLC
RECRUITING

Fairfield, Ohio, 45014, United States
Pan American Center for Oncology Trials - Mayaguez
RECRUITING

Mayagüez, 00680, Puerto Rico
Pan American Center for Oncology Trials, LLC
RECRUITING

Rio Piedras, 00935, Puerto Rico
Pan American Center for Oncology Trials, LLC
RECRUITING

San Juan, 00909, Puerto Rico
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Pia Fondazione Di Culto E Di Religione Card. G. Panico
NOT_YET_RECRUITING

Tricase, Lecce, 73039, Italy
Pratia Onkologia Katowice
NOT_YET_RECRUITING

Katowice, Silesian Voivodeship, 40-519, Poland
Pratia Poznań
NOT_YET_RECRUITING

Poznan, 60-192, Poland
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Rabin Medical Center
NOT_YET_RECRUITING

Petah Tikva, HA Merkaz, 4941492, Israel
Radnet/Houston Medical Imaging
RECRUITING

Houston, Texas, 77098, United States
Renown Regional Medical Center
RECRUITING

Reno, Nevada, 89502, United States
Rocky Mountain Cancer Centers - Boulder
RECRUITING

Boulder, Colorado, 80303, United States
SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu
NOT_YET_RECRUITING

Opole, 45-061, Poland
Saitama Medical University International Medical Center
RECRUITING

Hidaka, Saitama, 350-1298, Japan
Saitama Prefectural Cancer Center
RECRUITING

Kitaadachi-gun, Saitama, 362-0806, Japan
Shizuoka Cancer Center
RECRUITING

Nagaizumi-cho, Shizuoka, 411-8777, Japan
Sourasky Medical Center
NOT_YET_RECRUITING

Tel Aviv, TELL ABĪB, 6423906, Israel
Taipei Veterans General Hospital
NOT_YET_RECRUITING

Taipei, 11217, Taiwan
Texas Oncology - Gulf Coast
RECRUITING

Beaumont, Texas, 77702, United States
Texas Oncology - Gulf Coast
RECRUITING

Houston, Texas, 77024, United States
Texas Oncology - Gulf Coast
RECRUITING

Houston, Texas, 77054, United States
Texas Oncology - Gulf Coast
RECRUITING

Houston, Texas, 77070, United States
Texas Oncology - Gulf Coast
RECRUITING

Humble, Texas, 77338, United States
Texas Oncology - Gulf Coast
RECRUITING

Pearland, Texas, 77584, United States
Texas Oncology - Gulf Coast
RECRUITING

Sugar Land, Texas, 77479, United States
Texas Oncology - Gulf Coast
RECRUITING

The Woodlands, Texas, 77380, United States
Texas Oncology - Northeast Texas
RECRUITING

Denison, Texas, 75020, United States
Texas Oncology - Northeast Texas
RECRUITING

Denton, Texas, 76201, United States
Texas Oncology - Northeast Texas
RECRUITING

Flower Mound, Texas, 75028, United States
Texas Oncology - Northeast Texas
RECRUITING

Longview, Texas, 75601, United States
Texas Oncology - Northeast Texas
RECRUITING

Tyler, Texas, 75702, United States
Texas Oncology - West Texas
RECRUITING

Abilene, Texas, 79606, United States
Texas Oncology - West Texas
RECRUITING

Amarillo, Texas, 79124, United States
Texas Oncology - West Texas
RECRUITING

El Paso, Texas, 79902, United States
Texas Oncology - West Texas
RECRUITING

El Paso, Texas, 79915, United States
Texas Oncology - West Texas
RECRUITING

El Paso, Texas, 79938, United States
Texas Oncology - West Texas
RECRUITING

Midland, Texas, 79701, United States
Texas Oncology - West Texas
RECRUITING

Odessa, Texas, 79761, United States
Texas Oncology - West Texas
RECRUITING

Wichita Falls, Texas, 76310, United States
The Cancer & Hematology Centers
RECRUITING

Big Rapids, Michigan, 49307, United States
The Cancer & Hematology Centers
RECRUITING

Grand Rapids, Michigan, 49503, United States
The Cancer & Hematology Centers
RECRUITING

Grand Rapids, Michigan, 49546, United States
The Cancer & Hematology Centers
RECRUITING

Holland, Michigan, 49424, United States
The Cancer & Hematology Centers
RECRUITING

Norton Shores, Michigan, 49444, United States
The Cancer Institute Hospital of JFCR
RECRUITING

Koto-ku, Tokyo, 135-8550, Japan
US Oncology Investigational Products Center
RECRUITING

Irving, Texas, 75063, United States
US Oncology Investigational Products Center (IPC)
RECRUITING

Irving, Texas, 75063, United States
Virginia Cancer Institute
NOT_YET_RECRUITING

Mechanicsville, Virginia, 23116, United States
Virginia Cancer Institute
NOT_YET_RECRUITING

Midlothian, Virginia, 23112, United States
Virginia Cancer Institute
NOT_YET_RECRUITING

Petersburg, Virginia, 23805, United States
Virginia Cancer Institute
NOT_YET_RECRUITING

Richmond, Virginia, 23229, United States
Virginia Cancer Institute
NOT_YET_RECRUITING

Richmond, Virginia, 23235, United States
Virginia Cancer Specialists, PC
RECRUITING

Arlington, Virginia, 22201, United States
Virginia Cancer Specialists, PC
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Cancer Specialists, PC
RECRUITING

Manassas, Virginia, 20110, United States
Virginia Cancer Specialists, PC
RECRUITING

Reston, Virginia, 20190, United States
Virginia Cancer Specialists, PC
RECRUITING

Woodbridge, Virginia, 22191, United States

Conditions

Explore the condition pages connected to this study.

COLONIC DISEASES COLONIC DISEASES COLORECTAL NEOPLASMS DIGESTIVE SYSTEM DISEASES DIGESTIVE SYSTEM NEOPLASMS GASTROINTESTINAL DISEASES GASTROINTESTINAL DISEASES GASTROINTESTINAL NEOPLASMS INTESTINAL DISEASES INTESTINAL NEOPLASMS NEOPLASMS BY SITE NEOPLASMS BY SITE RECTAL DISEASES