DIGESTIVE SYSTEM NEOPLASMS

This study tests two different chemotherapy combinations for people with metastatic colorectal cancer that has spread and needs a second treatment. About 280 adults will be randomly assigned to receive either FOLFIRI or irinotecan, with or without bevacizumab. The goal is to see …

This Phase 3 trial is testing whether a new medicine called PF-08634404, combined with standard chemotherapy, works better than the current treatment Avastin plus chemo for people whose colorectal cancer has spread. About 800 participants who have not had prior treatment for meta…

This study tests a powerful combination of treatments for people with advanced liver cancer that cannot be surgically removed. The approach uses heat-based ablation to destroy the main tumor, followed by targeted therapy (lenvatinib), immunotherapy (tislelizumab), and a procedure…

This study tests a procedure called EUS-guided radiofrequency ablation (RFA) for solid tumors in the stomach, liver, kidney, or adrenal glands. It involves using an endoscope to insert a needle that heats and destroys tumor tissue. The study will enroll 30 adults who cannot have …

This study looks at how common muscle loss (sarcopenia) is in people with gastrointestinal cancer. Researchers will use a short questionnaire to screen patients before and during treatment. Those flagged as at risk will get extra nutritional support. The goal is to see if early d…