New shot option for immune deficiency shows promise in early trial
NCT ID NCT05755035
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new medicine called TAK-881, a concentrated antibody solution given under the skin, in 65 people with primary immunodeficiency diseases (PIDD). The goal was to see how well the body absorbs it and if it is safe compared to an existing treatment (HYQVIA). Participants received either TAK-881 or HYQVIA for up to 51 weeks, with regular clinic visits every 3-4 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
TAK-881 (immune globulin with hyaluronidase)
What this could lead to
If successful, TAK-881 could offer a new option for people with primary immunodeficiency to receive antibody replacement therapy under the skin.
What could go wrong
This is a mid-stage trial with only 65 participants, so results may not apply to everyone. As with any immunoglobulin product, there is a risk of allergic reactions or infections.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PRIMARY IMMUNODEFICIENCY DISEASES (PID) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Aarhus Universitetshospital
Aarhus, 8200, Denmark
-
Allergy Partners of North Texas
Dallas, Texas, 75230, United States
-
Allergy and Asthma Clinical Research
Walnut Creek, California, 94598, United States
-
Central Georgia Infectious Disease Consultants
Macon, Georgia, 31201, United States
-
Duke Asthma, Allergy and Airway Center
Durham, North Carolina, 27705, United States
-
Fakultni Nemocnice v Motole
Prague, 14300, Czechia
-
Fakultni nemocnice u sv. Anny v Brne - ICRC
Brno, 656 91, Czechia
-
Hospital Sant Joan de Deu Barcelona
Esplugues de Llobregat, Barcelona, 08950, Spain
-
Instytut Pomnik - Centrum Zdrowia Dziecka
Warsaw, Masovian Voivodeship, 00-999, Poland
-
Klinika Deti a Dorastu - Odborne Ambulancie UNM a JLF UK Martin
Martin, 036 01, Slovakia
-
Louisiana State University Health Science Center-New Orleans
New Orleans, Louisiana, 70118, United States
-
Montefiore Medical Center
The Bronx, New York, 10461, United States
-
NUDCH (National Institute of Children's Diseases)
Bratislava, 833 40, Slovakia
-
National Jewish Medical And Research Center
Denver, Colorado, 80206, United States
-
Northwell Health
Great Neck, New York, 11021, United States
-
OKIA, s.r.o
Košice, 040 01, Slovakia
-
Odense University Hospital
Odense, 5000, Denmark
-
Optimed Research, LTD
Columbus, Ohio, 43235, United States
-
Osrodek Pediatryczny im. DR J. Korczaka, Wojewodzkie Wielospecjalistyczne Centrum i Traumatologii im. M. Kopernika w Lodzi
Lodz, 90329, Poland
-
Rush University Medical Center - University Cardiovascular Surgeons
Chicago, Illinois, 60612-3852, United States
-
Sneeze, Wheeze, & Itch Associates, LLC
Normal, Illinois, 61761, United States
-
Tanner Clinic
Murray, Utah, 84107, United States
-
Universitaetsklinikum Tuebingen (UKT)
Tübingen, 72076, Germany
-
Universitair Medisch Centrum Utrecht (UMC Utrecht)
Utrecht, 3584 CX, Netherlands
-
University Hospital Brno (Fakultni Nemocnice Brno) - Children's Hospital (Detska nemocnice)
Brno, 62500, Czechia
-
University Hospital Carl Gustav Carus
Dresden, 01307, Germany
-
University Hospital La Paz
Madrid, 28046, Spain
-
University of California Irvine Medical Center
Irvine, California, 92697, United States
-
University of South Florida
St. Petersburg, Florida, 33701, United States
-
Uniwersyteckie Centrum Kliniczne, KLINIKA PEDIATRII, HEMATOLOGII I ONKOLOGII
Gdansk, Pomeranian Voivodeship, 80-952, Poland
-
Vital Prospects Clinical Research Institute, PC
Tulsa, Oklahoma, 74136, United States
-
Wojskowy Instytut Medyczny,Centralny Szpital Kliniczny Ministerstwa Obronty Narodowej
Warsaw, Masovian Voivodeship, 04-141, Poland