New hope for kids with severe gut disease: drug shows promise in major trial
NCT ID NCT04779307
First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 23 times
Summary
This study tested a medicine called vedolizumab in 121 children with moderate to severe ulcerative colitis, a condition causing gut inflammation and pain. The goal was to see if the drug could bring about remission—meaning symptoms improve and the gut looks healthy on camera. Participants first received three doses over 6 weeks, then those who responded continued with a maintenance dose every 8 weeks. The study measured how many children achieved remission at 54 weeks and tracked side effects.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AOU dell'Universita degli Studi della Campania Luigi Vanvitelli - Piazza Luigi Miraglia, 2
Naples, 280138, Italy
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Advocate Children's Hospital Park Ridge
Park Ridge, Illinois, 60068, United States
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Attikon University General Hospital
Chaïdári, Attica, 124 62, Greece
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Azienda Ospedaliera Universitaria Federico II
Naples, Campania, 80131, Italy
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Azienda Ospedaliera Universitaria Policlinico Umberto I - Universita di Roma La Sapienza
Rome, Lazio, 00161, Italy
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Azienda Ospedaliero Universitaria A Meyer - INCIPIT - PIN
Florence, Tuscany, 50139, Italy
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Azienda USL di Bologna
Bologna, Emilia-Romagna, 40133, Italy
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Beijing Children's Hospital, Capital Medical University - PIN
Beijing, Beijing Municipality, 100045, China
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Birmingham Women's and Children's NHS Foundation Trust
Birmingham, West Midlands, B4 6NH, United Kingdom
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Borsod-Abauj-Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktatokorhaz
Miskolc, 3526, Hungary
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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British Columbia Children's Hospital
Vancouver, British Columbia, V6H 3V4, Canada
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Carilion Children's Tanglewood Center
Roanoke, Virginia, 24013-2253, United States
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Carmel Medical Center
Haifa, 3436212, Israel
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Children's Hospital "Agia Sofia"
Athens, Attica, 115 27, Greece
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Children's Hospital at Westmead
Westmead, New South Wales, 2145, Australia
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Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, 201102, China
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Childrens Center For Digestive Healthcare
Atlanta, Georgia, 30318-4833, United States
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Clinexpert Gyogycentrum
Budapest, 1033, Hungary
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Fondazione IRCCS San Gerardo dei Tintori - ASST di Monza A. O. San Gerardo
Monza, Monza E Brianza, 20900, Italy
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Gachon University Gil Medical Center
Seoul, Incheon Gwang'yeogsi, 3080, South Korea
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Gornoslaskie Centrum Zdrowia Dziecka Im. Sw. Jana Pawla II Spsk Nr 6 Sum W Katowicach
Katowice, Silesian Voivodeship, 40-752, Poland
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Goryeb Children's Hospital
Morristown, New Jersey, 07960-6136, United States
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Great Ormond Street Hospital
London, London, City of, WC1N 3JH, United Kingdom
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Hadassah Medical Center - PPDS
Jerusalem, Jerusalem, 91120, Israel
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Henan Children's Hospital Zhengzhou Children's Hospital
Zhengzhou, Henan, 450000, China
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Instytut 'Pomnik - Centrum Zdrowia Dziecka'
Warsaw, Masovian Voivodeship, 04-736, Poland
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Instytut Centrum Zdrowia Matki Polki
Lodz, Łódź Voivodeship, 93-338, Poland
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Ippokratio General Hospital of Thessaloniki
Thessaloniki, 546 42, Greece
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Japanese Red Cross Kumamoto Hospital
Kumamoto, 861-8520, Japan
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Juntendo University Hospital
Bunkyo-Ku, Tokyo, 113-8431, Japan
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Klinika Za Djecje Bolesti Zagreb
Zagreb, City of Zagreb, 10000, Croatia
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Korczowski Bartosz, Gabinet Lekarski
Rzeszów, Podkarpackie Voivodeship, 35-302, Poland
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Kurume University Hospital
Kurume, Hukuoka, 830-0011, Japan
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Kyungpook National University Chilgok Hospital
Daegu, Daegu Gwang'yeogsi, 41404, South Korea
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London Health Sciences Centre
London, Ontario, N6A 5W9, Canada
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MNGI Digestive Health PA-Plymouth
Minneapolis, Minnesota, 55413, United States
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Mayo Clinic - PIN
Rochester, Minnesota, 55905-0001, United States
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Monash Health, Monash Medical Centre
Clayton, Victoria, 3168, Australia
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National Center for Child Health and Development
Setagaya-ku, Tokyo, 157-8535, Japan
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Noahs Ark Childrens Hospital for Wales
Cardiff, CF14 4XW, United Kingdom
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Phoenix Childrens Hospital -1919 E Thompson Rd
Phoenix, Arizona, 85016-7710, United States
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Queensland Childrens Hospital
South Brisbane, Queensland, 4101, Australia
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Rady Childrens Hospital San Diego - PIN
San Diego, California, 92123, United States
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Rambam Medical Center - PPDS
Haifa, 31096, Israel
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Royal Children's Hospital Melbourne - PIN
Parkville, Victoria, 3052, Australia
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SPZOZ Centralny Szpital Kliniczny UM w Lodzi - ul. Pomorska 251
Lodz, Łódź Voivodeship, 91-738, Poland
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Saitama Children's Medical Center
Saitama, 330-8777, Japan
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Samsung Medical Center
Seoul, Seoul Teugbyeolsi, 06351, South Korea
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Schneider Childrens Medical Center of Israel Petah Tikvah PIN
Petah Tikva, 49100, Israel
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Semmelweis Egyetem
Budapest, 1085, Hungary
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Seoul National University Hospital
Seoul, Seoul Teugbyeolsi, 21565, South Korea
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Shaare Zedek Medical Center
Jerusalem, Jerusalem, 91031, Israel
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Tel Aviv Sourasky Medical Center
Tel Aviv, 64239, Israel
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Texas Childrens Hospital West Campus
Houston, Texas, 77030-2358, United States
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The Children's Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310003, China
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The Royal London Hospital
London, London, City of, E1 1BB, United Kingdom
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Twoja Przychodnia SCM
Szczecin, West Pomeranian Voivodeship, 71-434, Poland
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UPMC Children's Hospital of Pittsburgh-120 Lytton Ave
Pittsburgh, Pennsylvania, 15224-1334, United States
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UZ Antwerpen
Edegem, Antwerpen, 2650, Belgium
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Universitair Ziekenhuis Brussel - PIN
Jette, Brussels Capital, 1090, Belgium
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Universitaire Ziekenhuizen(UZ)Leuven-Campus Gasthuisberg
Leuven, Vlaams Brabant, 3000, Belgium
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University of Alberta Hospital
Edmonton, Alberta, T6G 2S2, Canada
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Uniwersytecki Szpital Dzieciecy
Krakow, Lesser Poland Voivodeship, 30-663, Poland
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WIP Warsaw IBD Point Profesor Kierkus
Warsaw, Masovian Voivodeship, 00-728, Poland
Conditions
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